Bacillus subtilis HU58

Bacillus subtilis HU58 is a spore-forming probiotic strain with a relatively well-developed human clinical evidence base compared to many other Bacillus strains. Multiple randomized controlled trials have investigated it primarily in the context of antibiotic-associated diarrhea in both adults and children; however, several of these trials tested HU58 in multi-strain formulations, so strain-specific attribution requires care. Preliminary human research has also examined post-meal immune and inflammatory markers, though these findings are early and should not be interpreted as established clinical benefits. The spore form's shelf stability and gastric acid resistance have been documented in laboratory settings. These are research topics, not findings; the papers do not establish that this strain treats or prevents any condition.