Bacillus subtilis
Bacillus subtilis is a Gram-positive, rod-shaped bacterium widely distributed in soil and food environments, including fermented products. Animal studies have examined the strain's potential effects on digestive health and immune function. In vitro research has investigated its biofilm formation and metabolic capabilities. Human clinical evidence is limited, and strain-specific efficacy remains to be established through randomized controlled trials.
Where it's been studied Tags come from a conservative keyword scan of each paper's title, abstract, and summary. A tag is research coverage, not measured effect. How we classify this →
Share of this strain's 585 body-system-tagged papers that concern each system. Research coverage, not measured effect.
Symptoms in the research A tag means the paper's text names the symptom or condition — research coverage, not evidence of benefit. How we classify this →
Share of this strain's 99 symptom-tagged papers that mention each symptom or condition. Research coverage, not evidence of benefit.
+13 more symptoms
Strains of this species
28 strains of Bacillus subtilis in the index, with 869 linked papers between them.
Bacillus subtilis DE111
Bacillus subtilis strain DE111 is a gram-positive spore-forming bacterium marketed as a probiotic supplement.
Bacillus subtilis HU58
Bacillus subtilis HU58 is a spore-forming probiotic strain with a relatively well-developed human clinical evidence base compared to many other Bacillus strains.
Bacillus subtilis DCP04
Bacillus subtilis DCP04 is a strain isolated from doenjang, a traditional Korean fermented soybean paste.
Bacillus subtilis NPA6
Bacillus subtilis NPA6 is a strain of B. subtilis, a spore-forming species with a long history of use in fermented foods and agricultural applications.
Bacillus subtilis RBM2
Bacillus subtilis RBM2 appears in the literature primarily in the context of environmental plastic biodegradation rather than human probiotic research.
Bacillus subtilis ATCC 6633
Bacillus subtilis ATCC 6633 is a spore-forming aerobic bacterium widely used in research and biotechnology.
Bacillus subtilis F6
Bacillus subtilis F6 is a Bacillus subtilis strain for which no strain-specific primary or secondary research papers were identified in the indexed literature.
Bacillus subtilis W7
Bacillus subtilis W7 is a spore-forming bacterium belonging to a species with a long history of use in fermented foods and agricultural biocontrol.
Bacillus subtilis P22
Bacillus subtilis P22 is a strain designation within B.
Bacillus subtilis ACT-8
Bacillus subtilis ACT-8 is a strain for which no indexed research papers were identified in the current evidence base.
Bacillus subtilis CSM5
Bacillus subtilis CSM5 is a designated strain of B.
Bacillus subtilis P165
Bacillus subtilis P165 is a designated strain within the well-studied B.
Bacillus subtilis ATCC 21332
Bacillus subtilis ATCC 21332 is a strain studied primarily for its production of surfactin, a lipopeptide (fat-linked peptide) compound with antimicrobial and biosurfactant properties.
Bacillus subtilis N6
Bacillus subtilis N6 appears in the indexed literature in a single 2026 in vitro study examining polyester fiber degradation, an environmental biotechnology application with no relation to human health or probiotic suppl…
Bacillus subtilis ZE15
Bacillus subtilis strain ZE15 is a gram-positive soil bacterium.
Bacillus subtilis ZE16
Bacillus subtilis ZE16 is a strain for which no primary or secondary relevance papers were identified in the current research index.
Bacillus subtilis ZE12
Bacillus subtilis ZE12 is a named strain of the widely studied Bacillus subtilis species.
Bacillus subtilis BPM12
Bacillus subtilis BPM12 has been studied in a single 2023 in vitro publication examining its ability to hydrolyze BHET (bis(2-hydroxyethyl) terephthalate), a breakdown product of polyethylene terephthalate (PET) plastic,…
Bacillus subtilis BI8
Bacillus subtilis BI8 appears in this index in the context of environmental microbiology research.
Bacillus subtilis B26
Bacillus subtilis B26 is a plant-associated strain characterized primarily in agricultural research for its ability to colonize grass and crop roots, promote plant growth, and confer drought tolerance.
Bacillus subtilis A4
Bacillus subtilis A4 is a spore-forming bacterium belonging to a species with broad applications in fermented foods (notably natto in Japan and Africa's dawadawa), industrial enzyme production, and agricultural biocontro…
Bacillus subtilis FW1
Bacillus subtilis FW1 is a named isolate of Bacillus subtilis with no strain-specific published evidence in the current indexed literature for probiotic or human health applications.
Bacillus subtilis P74 I
Bacillus subtilis P74-I is a designated strain of B.
Bacillus subtilis MTCC 144
Bacillus subtilis MTCC 144 is an Indian culture collection deposit within the B.
Research Study-type filters use AI-classified labels, audited but not guaranteed — check the paper itself before leaning on one. How we classify this →
1342 papers reference this strain in the probiotic database.
Discussion
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Citations
Selected papers that name this strain.
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[1]
Source →Spore-Based Probiotic Bacillus subtilis: Current Applications in Humans and Future Perspectives· Fermentation · 2024
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[2]
PMID 37840737 →Probiotic properties of Bacillus subtilis DG101 isolated from the traditional Japanese fermented food nattō· Frontiers in Microbiology · 2023
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[3]
PMID 37672039 →Mechanism of TLR4-Mediated Anti-Inflammatory Response Induced by Exopolysaccharide from the Probiotic Bacillus subtilis· The Journal of Immunology · 2023
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[4]
PMID 38115003 →Feeding with 4,4′-diaponeurosporene-producing Bacillus subtilis enhances the lactogenic immunity of sow· BMC Veterinary Research · 2023
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[5]
PMID 35891178 →Safety and Immunogenicity of Inactivated Bacillus subtilis Spores as a Heterologous Antibody Booster for COVID-19 Vaccines· Vaccines · 2022
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[6]
Source →Bacillus subtilis chassis in biomanufacturing 4.0· Journal of Chemical Technology & Biotechnology · 2022
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[7]
PMID 36269141 →The probiotic Bacillus subtilis BS50 decreases gastrointestinal symptoms in healthy adults: a randomized, double-blind, placebo-controlled trial· Gut Microbes · 2022
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[8]
PMID 34408741 →Presence and Germination of the Probiotic Bacillus subtilis DE111® in the Human Small Intestinal Tract: A Randomized, Crossover, Double-Blind, and Placebo-Controlled Study· Frontiers in Microbiology · 2021
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[9]
PMID 33671071 →Examining the Gastrointestinal and Immunomodulatory Effects of the Novel Probiotic Bacillus subtilis DE111· International Journal of Molecular Sciences · 2021
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[10]
PMID 33668992 →Safety Assessment of Bacillus subtilis MB40 for Use in Foods and Dietary Supplements· Nutrients · 2021