Strain Profile
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Bacillus subtilis
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Environmental
Where this strain was first isolated, curated from the literature and culture-collection catalogs. It describes provenance only — not suitability, and not benefit.
How we classify this →
Sequenced
Whether a public genome assembly is linked for this strain. Without one the genome screens cannot run. It is not a verdict on the organism.
How we classify this →
Public genome assembly available
Bacillus subtilis is a Gram-positive, rod-shaped bacterium widely distributed in soil and food environments, including fermented products. Animal studies have examined the strain's potential effects on digestive health and immune function. In vitro research has investigated its biofilm formation and metabolic capabilities. Human clinical evidence is limited, and strain-specific efficacy remains to be established through randomized controlled trials.
Where it's been studied Tags come from a conservative keyword scan of each paper's title, abstract, and summary. A tag is research coverage, not measured effect. How we classify this →
Share of this strain's 585 body-system-tagged papers that concern each system. Research coverage, not measured effect.
Symptoms in the research A tag means the paper's text names the symptom or condition — research coverage, not evidence of benefit. How we classify this →
Share of this strain's 99 symptom-tagged papers that mention each symptom or condition. Research coverage, not evidence of benefit.
+13 more symptoms
Research Study-type filters use AI-classified labels, audited but not guaranteed — check the paper itself before leaning on one. How we classify this →
1342 papers reference this strain in the probiotic database.
Match confidence
How strongly this paper was matched to this strain when the corpus was linked. It orders the list — it says nothing about the study's quality or its findings.
How we classify this →
2025
IN_VITRO
2025
IN_VITRO
2025
IN_VITRO
2025
ANIMAL
2024
ANIMAL
2024
REVIEW
2024
OTHER
2024
ANIMAL
2024
IN_VITRO
2024
IN_VITRO
2024
IN_VITRO
2024
IN_VITRO
2024
IN_VITRO
2024
IN_VITRO
2024
IN_VITRO
2024
ANIMAL
2024
ANIMAL
2024
OTHER
2024
OBSERVATIONAL
2024
IN_VITRO
Browse all 1,342 papers →
Enhancement of gut barrier integrity by a Bacillus subtilis secreted metabolite through the GADD45A‐Wnt/β‐catenin pathway
· iMeta
Surfactin facilitates establishment of Bacillus subtilis in synthetic communities
· The ISME Journal
Engineered bacillus subtilis enhances bone regeneration via immunoregulation and anti-Infection
· Bioactive Materials
Bacillus subtilis HGCC-1 improves growth performance and liver health via regulating gut microbiota in golden pompano
· Animal Microbiome
Oregano essential oil and Bacillus subtilis role in enhancing broiler’s growth, stress indicators, intestinal integrity, and gene expression under high stocking density
· Scientific Reports
Spore-Based Probiotic Bacillus subtilis: Current Applications in Humans and Future Perspectives
· Fermentation
Competition for iron shapes metabolic antagonism between Bacillus subtilis and Pseudomonas marginalis
· The ISME Journal
Effect of a probiotic supplement (Bacillus subtilis) on struggling behavior, immune response, and meat quality of shackled broiler chickens exposed to preslaughter stress
· Poultry Science
Isolation and characterization of an antimicrobial Bacillus subtilis strain O-741 against Vibrio parahaemolyticus
· PLoS ONE
Study of selenium enrichment metabolomics in Bacillus subtilis BSN313 via transcriptome analysis
· Biotechnology and Applied Biochemistry
Immunomodulatory properties of Bacillus subtilis extracellular vesicles on rainbow trout intestinal cells and splenic leukocytes
· Frontiers in Immunology
Adaptive laboratory evolution for improved tolerance of vitamin K in Bacillus subtilis
· Applied Microbiology and Biotechnology
A “love match” score to compare root exudate attraction and feeding of the plant growth-promoting rhizobacteria Bacillus subtilis, Pseudomonas fluorescens, and Azospirillum brasilense
· Frontiers in Microbiology
Bacillus subtilis promotes plant phosphorus (P) acquisition through P solubilization and stimulation of root and root hair growth
· Physiologia Plantarum
Dynamic in situ detection in iRhizo-Chip reveals diurnal fluctuations of Bacillus subtilis in the rhizosphere
· Proceedings of the National Academy of Sciences
Engineered Bacillus subtilis as Oral Probiotics To Enhance Clearance of Blood Lactate
· ACS Synthetic Biology
Dietary probiotic based on a dual-strain Bacillus subtilis improves immunity, intestinal health, and growth performance of broiler chickens
· Journal of Animal Science
Antibiofilm Activity of the Marine Probiotic Bacillus subtilis C3 Against the Aquaculture-Relevant Pathogen Vibrio harveyi
· Probiotics and Antimicrobial Proteins
Effects of Trichoderma harzianum and Bacillus subtilis on the root and soil microbiomes of the soybean plant INTACTA RR2 PRO™
· Frontiers in Plant Science
Effects of Bacillus subtilis on in vitro ruminal fermentation and methane production
· Translational Animal Science
Discussion
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Citations
Selected papers that name this strain.
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[1]
Source →Spore-Based Probiotic Bacillus subtilis: Current Applications in Humans and Future Perspectives· Fermentation · 2024
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[2]
PMID 38115003 →Feeding with 4,4′-diaponeurosporene-producing Bacillus subtilis enhances the lactogenic immunity of sow· BMC Veterinary Research · 2023
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[3]
PMID 37840737 →Probiotic properties of Bacillus subtilis DG101 isolated from the traditional Japanese fermented food nattō· Frontiers in Microbiology · 2023
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[4]
PMID 37672039 →Mechanism of TLR4-Mediated Anti-Inflammatory Response Induced by Exopolysaccharide from the Probiotic Bacillus subtilis· The Journal of Immunology · 2023
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[5]
Source →Bacillus subtilis chassis in biomanufacturing 4.0· Journal of Chemical Technology & Biotechnology · 2022
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[6]
PMID 35891178 →Safety and Immunogenicity of Inactivated Bacillus subtilis Spores as a Heterologous Antibody Booster for COVID-19 Vaccines· Vaccines · 2022
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[7]
PMID 36269141 →The probiotic Bacillus subtilis BS50 decreases gastrointestinal symptoms in healthy adults: a randomized, double-blind, placebo-controlled trial· Gut Microbes · 2022
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[8]
PMID 34408741 →Presence and Germination of the Probiotic Bacillus subtilis DE111® in the Human Small Intestinal Tract: A Randomized, Crossover, Double-Blind, and Placebo-Controlled Study· Frontiers in Microbiology · 2021
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[9]
PMID 33668992 →Safety Assessment of Bacillus subtilis MB40 for Use in Foods and Dietary Supplements· Nutrients · 2021
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[10]
PMID 33671071 →Examining the Gastrointestinal and Immunomodulatory Effects of the Novel Probiotic Bacillus subtilis DE111· International Journal of Molecular Sciences · 2021