Strain Profile
· NCBI Species Taxon
1423
NCBI Taxonomy's node for this strain's species, not for the strain itself — NCBI has no strain-level node for it. A different identifier from the culture-collection deposit numbers below, which name a physical stock rather than a taxonomic node.
How we classify this →
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Bacillus subtilis DE111
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Environmental
Where this strain was first isolated, curated from the literature and culture-collection catalogs. It describes provenance only — not suitability, and not benefit.
How we classify this →
Sequenced
Whether a public genome assembly is linked for this strain. Without one the genome screens cannot run. It is not a verdict on the organism.
How we classify this →
Public genome assembly available
Bacillus subtilis strain DE111 is a gram-positive spore-forming bacterium marketed as a probiotic supplement. Research includes randomized controlled trials examining its associations with changes in blood lipids, endothelial function, immune markers, and gastrointestinal health in various populations including athletes and children. Animal studies and in vitro work have also investigated its physiological effects and thermal stability.
Where it's been studied Tags come from a conservative keyword scan of each paper's title, abstract, and summary. A tag is research coverage, not measured effect. How we classify this →
Share of this strain's 15 body-system-tagged papers that concern each system. Research coverage, not measured effect.
Symptoms in the research A tag means the paper's text names the symptom or condition — research coverage, not evidence of benefit. How we classify this →
Share of this strain's 7 symptom-tagged papers that mention each symptom or condition. Research coverage, not evidence of benefit.
Research Study-type filters use AI-classified labels, audited but not guaranteed — check the paper itself before leaning on one. How we classify this →
21 papers reference this strain in the probiotic database.
Match confidence
How strongly this paper was matched to this strain when the corpus was linked. It orders the list — it says nothing about the study's quality or its findings.
How we classify this →
2025
IN_VITRO
2024
ANIMAL
2023
IN_VITRO
2023
RCT
2022
ANIMAL
2021
RCT
2021
RCT
2020
RCT
2020
RCT
2020
RCT
2020
RCT
2020
RCT
2019
RCT
2018
OTHER
2018
RCT
2018
RCT
2018
OTHER
2018
OTHER
2017
OTHER
2017
RCT
Browse all 21 papers →
Thermal death time kinetics of three Bacillus strain probiotics in peptone media
· SHAREOK (University of Oklahoma; Oklahoma State University; Central Oklahoma University)
Bacillus subtilis DE111 partially reverses endothelial dysfunction in western-diet fed mice
· Beneficial Microbes
In vitro and in silico assessment of probiotic and functional properties of Bacillus subtilis DE111®
· Frontiers in Microbiology
Acute physiological effects following Bacillus subtilis DE111 oral ingestion – a randomised, double blinded, placebo-controlled study
· Beneficial Microbes
RETRACTED: Bacillus Subtilis DE111 Improves Endothelial Dependent Vascular Dilation in Mice Fed a Western Diet
· The FASEB Journal
Examining the Gastrointestinal and Immunomodulatory Effects of the Novel Probiotic Bacillus subtilis DE111
· International Journal of Molecular Sciences
Presence and Germination of the Probiotic Bacillus subtilis DE111® in the Human Small Intestinal Tract: A Randomized, Crossover, Double-Blind, and Placebo-Controlled Study
· Frontiers in Microbiology
Effect of Daily Bacillus subtilis DE111 Intake on GastrointestinalHealth and Respiratory Infections in Children Attending Day-care: ARandomised, Parallel, Double-blind, Placebo-controlled Study
· Journal of Probiotics & Health
Bacillus subtilis DE111 intake may improve blood lipids and endothelial function in healthy adults
· Beneficial Microbes
Daily intake of probiotic strain Bacillus subtilis DE111 supports a healthy microbiome in children attending day-care
· Beneficial Microbes
Plasma Amino Acid Response to Whey Protein Ingestion Following 28 Days of Probiotic (Bacillus subtilis DE111) Supplementation in Active Men and Women
· Journal of Functional Morphology and Kinesiology
Examining the Immunomodulatory Effects of the Novel Probiotic Bacillus subtilis de111
· Preprints.org
Tolerance and Effect of a Probiotic Supplement Delivered in Capsule Form
· Food and Nutrition Sciences
Probiotic Strain DE111 Supports Bowel Regularity in New Study
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Effects of Probiotic (Bacillus subtilis DE111) Supplementation on Immune Function, Hormonal Status, and Physical Performance in Division I Baseball Players
· Sports
Effects of Probiotic (Bacillus subtilis) Supplementation During Offseason Resistance Training in Female Division I Athletes
· The Journal of Strength and Conditioning Research
Probiotic Strain DE111 Can Now Be Used in Canada Foods without Novel Food Preapproval
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New Water-Soluble Spore-Forming Probiotic Strain Expands Delivery Formats, Including Functional Beverages, Gummies
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Spore-Forming Probiotic May Reduce Body Fat and Improve Athletic Performance, New Study Suggests
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The Effect of Bacillus subtilis DE111 on the Daily Bowel Movement Profile for People with Occasional Gastrointestinal Irregularity
· Journal of Probiotics & Health
Discussion
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Citations
Selected papers that name this strain.
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[1]
PMID 36713219 →In vitro and in silico assessment of probiotic and functional properties of Bacillus subtilis DE111®· Frontiers in Microbiology · 2023
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[2]
PMID 34408741 →Presence and Germination of the Probiotic Bacillus subtilis DE111® in the Human Small Intestinal Tract: A Randomized, Crossover, Double-Blind, and Placebo-Controlled Study· Frontiers in Microbiology · 2021
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[3]
Source →Examining the Immunomodulatory Effects of the Novel Probiotic Bacillus subtilis de111· Preprints.org · 2020
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[4]
Source →The Effect of Bacillus subtilis DE111 on the Daily Bowel Movement Profile for People with Occasional Gastrointestinal Irregularity· Journal of Probiotics & Health · 2017