Strain Profile
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Bifidobacterium bifidum Bb-02
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Human-origin
Where this strain was first isolated, curated from the literature and culture-collection catalogs. It describes provenance only — not suitability, and not benefit.
How we classify this →
Sequenced
Whether a public genome assembly is linked for this strain. Without one the genome screens cannot run. It is not a verdict on the organism.
How we classify this →
Public genome assembly available
Bifidobacterium bifidum BB-02 is a strain studied primarily in combination formulations alongside other Bifidobacterium and Lactobacillus species. In vitro work has examined its stability in food matrices such as yogurt and white-brined cheese, and a human randomized trial of a synbiotic blend examined gut microbiota composition in elderly participants. A subset of the clinical evidence comes from neonatal and preterm infant studies using multi-strain products, where BB-02 appeared as one component rather than a sole intervention. Strain-specific conclusions remain limited by the multi-strain study designs across this evidence base. These are research topics, not findings; the papers do not establish that this strain treats or prevents any condition.
Where it's been studied Tags come from a conservative keyword scan of each paper's title, abstract, and summary. A tag is research coverage, not measured effect. How we classify this →
Share of this strain's 13 body-system-tagged papers that concern each system. Research coverage, not measured effect.
Symptoms in the research A tag means the paper's text names the symptom or condition — research coverage, not evidence of benefit. How we classify this →
Share of this strain's 2 symptom-tagged papers that mention each symptom or condition. Research coverage, not evidence of benefit.
Research Study-type filters use AI-classified labels, audited but not guaranteed — check the paper itself before leaning on one. How we classify this →
19 papers reference this strain in the probiotic database.
Match confidence
How strongly this paper was matched to this strain when the corpus was linked. It orders the list — it says nothing about the study's quality or its findings.
How we classify this →
2024
ANIMAL
2022
RCT
2021
RCT
2021
IN_VITRO
2020
META_ANALYSIS
2020
REVIEW
2018
RCT
2014
ANIMAL
2011
IN_VITRO
2005
IN_VITRO
2004
RCT
2003
OTHER
2026
OBSERVATIONAL
2025
REVIEW
2021
REVIEW
2018
IN_VITRO
2018
IN_VITRO
2014
IN_VITRO
2024
IN_VITRO
Browse all 19 papers →
Food by-products as substrates for the design of a folate bio-enriched fermented beverage: evaluation of bioavailability and effects on vitamin D receptor (VDR) and folate transporters gene expression in vitro and in vivo
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Probiotic Supplementation in Very Low Birthweight Infants: Effects on Systemic Immunity and Intestinal Inflammation
· Current Developments in Nutrition
The effect of probiotic supplementation on the gut microbiota of preterm infants
· Journal of Medical Microbiology
Use of probiotics in the NICU: Evaluating the stability of a three-strain probiotic blend in various media for enteral feeding
· Journal of Neonatal-Perinatal Medicine
Probiotics for Preterm Infants: Which One(s) to Choose?
· PEDIATRICS
Probiotics and Preterm Infants
· Journal of Pediatric Gastroenterology and Nutrition
Gut microbiota of preterm infants supplemented with probiotics: sub-study of the ProPrems trial
· BMC Microbiology
Bifidobacterium longum subsp. infantis BB-02 attenuates acute murine experimental model of inflammatory bowel disease
· Beneficial Microbes
Effect of a synbiotic on microbial community structure in a continuous culture model of the gastric microbiota in enteral nutrition patients
· FEMS Microbiology Ecology
Effect of Inulin and Lactulose on Survival of Lactobacillus AcidophilusLA-5 and Bifidobacterium Bifidum BB-02 in Acidophilus-Bifidus Yoghurt
· Food Science and Technology International
Microbiological Effects of Consuming a Synbiotic Containing Bifidobacterium bifidum, Bifidobacterium lactis, and Oligofructose in Elderly Persons, Determined by Real-Time Polymerase Chain Reaction and Counting of Viable Bacteria
· Clinical Infectious Diseases
Survival of Lactobacillus acidophilus LA-5 and Bifidobacterium bifidum BB-02 in white-brined cheese
· International Journal of Food Sciences and Nutrition
Probiotic use in French neonatal intensive care units: A nationwide analysis of practice patterns and clinical outcomes
· Journal of Pediatric Gastroenterology and Nutrition
An update on probiotics in paediatrics
· Current Opinion in Clinical Nutrition & Metabolic Care
DO PROBIOTICS HAVE A FUTURE IN NEONATOLOGY?
· Neonatology surgery and perinatal medicine
Effect of vegetable by-products on folate production by starter and probiotic microorganisms to develop a bio-enriched fermented soy product
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Efeito de subprodutos vegetais na produção de folatos por microrganismos starter e probióticos para o desenvolvimento de um produto de soja fermentado bioenriquecido.
· Digital Library of Theses and Dissertations (Universidade de São Paulo)
Research of the glucooligosaccharides as prebiotics produced by Leuconostoc mesemteroide 6055
· Science and Technology of Food Industry
Effect of fruit by-products and orange pectin on folate (vitamin B9) production by selected starter and probiotic strains
· International Journal of Food Science & Technology
Discussion
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Citations
Selected papers that name this strain.
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[1]
Source →Food by-products as substrates for the design of a folate bio-enriched fermented beverage: evaluation of bioavailability and effects on vitamin D receptor (VDR) and folate transporters gene expression in vitro and in vivo· · 2024
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[2]
Source →Probiotic Supplementation in Very Low Birthweight Infants: Effects on Systemic Immunity and Intestinal Inflammation· Current Developments in Nutrition · 2022
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[3]
PMID 34431764 →The effect of probiotic supplementation on the gut microbiota of preterm infants· Journal of Medical Microbiology · 2021
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[4]
PMID 33323494 →Probiotics for Preterm Infants: Which One(s) to Choose?· PEDIATRICS · 2020
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[5]
PMID 32332478 →Probiotics and Preterm Infants· Journal of Pediatric Gastroenterology and Nutrition · 2020
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[6]
PMID 30424728 →Gut microbiota of preterm infants supplemented with probiotics: sub-study of the ProPrems trial· BMC Microbiology · 2018
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[7]
Source →Bifidobacterium longum subsp. infantis BB-02 attenuates acute murine experimental model of inflammatory bowel disease· Beneficial Microbes · 2014
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[8]
Source →Effect of Inulin and Lactulose on Survival of Lactobacillus AcidophilusLA-5 and Bifidobacterium Bifidum BB-02 in Acidophilus-Bifidus Yoghurt· Food Science and Technology International · 2005
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[9]
PMID 15614689 →Microbiological Effects of Consuming a Synbiotic Containing Bifidobacterium bifidum, Bifidobacterium lactis, and Oligofructose in Elderly Persons, Determined by Real-Time Polymerase Chain Reaction and Counting of Viable Bacteria· Clinical Infectious Diseases · 2004
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[10]
PMID 14630592 →Survival of Lactobacillus acidophilus LA-5 and Bifidobacterium bifidum BB-02 in white-brined cheese· International Journal of Food Sciences and Nutrition · 2003