Strain Profile
· NCBI Strain Taxon
552531
NCBI Taxonomy's node for this specific strain. A different identifier from the culture-collection deposit numbers below, which name a physical stock rather than a taxonomic node.
How we classify this →
Save
Bifidobacterium animalis BB-12
DEP
BB-12
◔
Human-origin
Where this strain was first isolated, curated from the literature and culture-collection catalogs. It describes provenance only — not suitability, and not benefit.
How we classify this →
Sequenced
Whether a public genome assembly is linked for this strain. Without one the genome screens cannot run. It is not a verdict on the organism.
How we classify this →
Public genome assembly available
Bifidobacterium animalis BB-12 is one of the most extensively studied Bifidobacterium strains, with a research record spanning food science, gut physiology, and clinical settings. In vitro studies have explored its behavior in fermented foods, its response to prebiotic substrates, and its role in gut barrier function, examining microbial diversity and intestinal permeability. A randomized controlled trial examined detection of BB-12 in the gastrointestinal tract of healthy volunteers following oral consumption. Preliminary animal research has examined potential interactions with neurological stress models, though those findings remain early and cannot be generalized to humans without further investigation. These are research topics, not findings; the papers do not establish that this strain treats or prevents any condition.
Where it's been studied Tags come from a conservative keyword scan of each paper's title, abstract, and summary. A tag is research coverage, not measured effect. How we classify this →
Share of this strain's 484 body-system-tagged papers that concern each system. Research coverage, not measured effect.
Symptoms in the research A tag means the paper's text names the symptom or condition — research coverage, not evidence of benefit. How we classify this →
Share of this strain's 219 symptom-tagged papers that mention each symptom or condition. Research coverage, not evidence of benefit.
+16 more symptoms
Research Study-type filters use AI-classified labels, audited but not guaranteed — check the paper itself before leaning on one. How we classify this →
948 papers reference this strain in the probiotic database.
Match confidence
How strongly this paper was matched to this strain when the corpus was linked. It orders the list — it says nothing about the study's quality or its findings.
How we classify this →
2026
ANIMAL
2026
ANIMAL
2026
RCT
2026
IN_VITRO
2026
IN_VITRO
2026
IN_VITRO
2026
REVIEW
2026
IN_VITRO
2026
OTHER
2026
OTHER
2026
ANIMAL
2026
IN_VITRO
2026
REVIEW
2026
IN_VITRO
2025
IN_VITRO
2025
ANIMAL
2025
IN_VITRO
2025
REVIEW
2025
ANIMAL
2025
RCT
Browse all 948 papers →
THE COMPLEX EFFECT OF BIFIDOBACTERIUM AND LACTOBACILLUS SPECIES AND METFORMIN ON MACROPHAGES POLARIZATION IN IN VIVO STUDIES
· Oncology
Paraprobiotics retain their ability to counteract diet-induced dysbiosis during shelf-life: an efficacy study correlating fecal metabolomic and microbiome changes
· Food Bioscience
Lactoferrin combined with Bifidobacterium animalis subsp. lactis BB-12 improves respiratory tract infections and modulates Gut microbiome function in children: a randomized, double-blind, placebo-controlled trial
· Frontiers in Pediatrics
Probiotic fermented goat milk incorporated with blackberry (Rubus sp.): A novel functional food product
· Journal of the Science of Food and Agriculture
Bifidobacterium animalis subsp. lactis BB-12 Primes Epithelial Antiviral Defenses and Restricts Influenza A Virus Replication in Human Intestinal Organoid-Derived Monolayers
· Microorganisms
Probiotic Lactic Acid Bacteria-Fermented Beverages from Bambara Groundnut and Cowpea Sprouts Modulate Gut Microbiota and Short-Chain Fatty Acids
· Foods
Encapsulation of probiotics to improve their survival: A focus on Bifidobacterium animalis subsp. lactis BB-12
· Food Chemistry X
Microencapsulation of Lactobacillus acidophilus LA-5 and Bifidobacterium animalis subsp. lactis BB-12 in alginate and pectin, and the effects on bacterial acid and bile resistance
· Biotech Studies
The Effect of Prebiotic (Inulin) Addition and Storage Time on the Fatty Acid Profile, Mineral Content, and Sensory Properties of Probiotic Fermented Drinks Produced from Cow’s Milk with Different Fat Contents
· Applied Sciences
Validação microbiológica de análogo a queijo simbiótico elaborado com amêndoas de castanha-de-caju.
· infoteca-e (Brazilian Agricultural Research Corporation)
INFLUENCE OF BIFIDOBACTERIUM ANIMALIS SUBSP. LACTIS BB-12 AND LACTOBACILLUS RHAMNOSUS GG ON POLARIZATION OF TUMOR-ASSOCIATED MACROPHAGES
· Experimental Oncology
Antiviral activity of postbiotics from Bifidobacterium animalis subsp. lactis BB-12 and Lacticaseibacillus rhamnosus GG against SARS-CoV-2: In-vitro and food model evaluation
· Enzyme and Microbial Technology
Health benefits of Bifidobacterium animalis subsp. lactis BB-12 in infants and children: a mini-review
· Frontiers in Microbiology
Cassava (Manihot esculenta) as encapsulant of Bifidobacterium animalis: Structural characteristics, storage stability and gastrointestinal protection
· Food Bioscience
Characterization of Lactiplantibacillus plantarum subsp. plantarum and Bifidobacterium animalis spp. lactis BB-12 postbiotics: In vivo and in vitro experiments against foodborne pathogens
· LWT
Synbiotic combination of 2′-fucosyllactose and Bifidobacterium mitigates neurodevelopmental disorders and ASD-like behaviors induced by valproic acid
· Food & Function
Justification of Fermentation Parameters for Yogurt Base in the Production of Yogurt Products for Athletes
ОБГРУНТУВАННЯ ПАРАМЕТРІВ ФЕРМЕНТАЦІЇ ЙОГУРТОВОЇ ОСНОВИ У ВИРОБНИЦТВІ ЙОГУРТОВИХ ПРОДУКТІВ ДЛЯ СПОРТСМЕНІВ
· Таврійський науковий вісник Серія Технічні науки
Understanding the probiotic health benefits of Bifidobacterium animalis subsp. lactis, BB-12™
· Frontiers in Microbiology
Bifidobacterium animalis subsp. lactis BB-12 attenuates diabetic retinopathy through gut microbiota modulation: evidence for the gut–retinal axis
· Frontiers in Cellular and Infection Microbiology
Probiotic Blend of Lactobacillus acidophilus LA‐5 and Bifidobacterium animalis ssp. Lactis BB‐12 in Non‐constipated Irritable Bowel Syndrome: A Double‐Blind Randomized Placebo‐Controlled Trial
· Journal of Gastroenterology and Hepatology
Discussion
Be the first to comment.
Sign in to join the discussion.
No comments yet.
Citations
Selected papers that name this strain.
-
[1]
PMID 42075148 →Bifidobacterium animalis subsp. lactis BB-12 Primes Epithelial Antiviral Defenses and Restricts Influenza A Virus Replication in Human Intestinal Organoid-Derived Monolayers· Microorganisms · 2026
-
[2]
PMID 41800422 →Health benefits of Bifidobacterium animalis subsp. lactis BB-12 in infants and children: a mini-review· Frontiers in Microbiology · 2026
-
[3]
Source →Synbiotic-supplemented organic formula enhances infant gut health: a randomized controlled trial· Functional Foods in Health and Disease · 2025
-
[4]
PMID 40673154 →Understanding the probiotic health benefits of Bifidobacterium animalis subsp. lactis, BB-12™· Frontiers in Microbiology · 2025
-
[5]
PMID 41255078 →Probiotic Blend of Lactobacillus acidophilus LA‐5 and Bifidobacterium animalis ssp. Lactis BB‐12 in Non‐constipated Irritable Bowel Syndrome: A Double‐Blind Randomized Placebo‐Controlled Trial· Journal of Gastroenterology and Hepatology · 2025
-
[6]
PMID 41002283 →Effect of probiotic administration of Bifidobacterium animalis subsp. lactis BB‐12 and Lactiplantibacillus plantarum ATCC 14917 on metabolic profiles in an IBS‐D rat model: a metabolomic analysis approach· Journal of the Science of Food and Agriculture · 2025
-
[7]
Source →Enteral supplementation with Bifidobacterium animalis Bb-12 modulates gut microbiome and improves intestinal barrier in very preterm infants: a randomized, controlled trial· Research Square · 2024
-
[8]
Source →The Impact of Administering Prophylactic Probiotics to Premature Infants in Neonatal Intensive Care Units on Healthcare-Associated Infections, Necrotizing Enterocolitis, and Mortality· Flora the Journal of Infectious Diseases and Clinical Microbiology · 2024
-
[9]
PMID 37333640 →Administration of Bifidobacterium animalis subsp. lactis strain BB-12® in healthy children: characterization, functional composition, and metabolism of the gut microbiome· Frontiers in Microbiology · 2023
-
[10]
PMID 38271203 →Efficacy and Safety of BB-12 Supplemented Strawberry Yogurt For Healthy Children on Antibiotics (PLAY ON)· · 2023