Strain Profile
· NCBI Species Taxon
1681
NCBI Taxonomy's node for this strain's species, not for the strain itself — NCBI has no strain-level node for it. A different identifier from the culture-collection deposit numbers below, which name a physical stock rather than a taxonomic node.
How we classify this →
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Bifidobacterium bifidum
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Human-origin
Where this strain was first isolated, curated from the literature and culture-collection catalogs. It describes provenance only — not suitability, and not benefit.
How we classify this →
Sequenced
Whether a public genome assembly is linked for this strain. Without one the genome screens cannot run. It is not a verdict on the organism.
How we classify this →
Public genome assembly available
Bifidobacterium bifidum is a species naturally present in the human gut, particularly abundant in breastfed infants, where it plays a role in fermenting complex carbohydrates, including human milk oligosaccharides and certain brans. Research across various B. bifidum strains includes in vitro evidence for exopolysaccharide production and mineral release from dietary fiber, and an observational study in low birth weight infants examined systemic and mucosal immune responses in relation to one strain (OLB6378). Because this index entry is at the species level rather than a specific named strain, findings vary considerably across strains and should not be generalized; strain-level evidence should be consulted for any specific health application. These are research topics, not findings; the papers do not establish that this strain treats or prevents any condition.
Where it's been studied Tags come from a conservative keyword scan of each paper's title, abstract, and summary. A tag is research coverage, not measured effect. How we classify this →
Share of this strain's 418 body-system-tagged papers that concern each system. Research coverage, not measured effect.
Symptoms in the research A tag means the paper's text names the symptom or condition — research coverage, not evidence of benefit. How we classify this →
Share of this strain's 130 symptom-tagged papers that mention each symptom or condition. Research coverage, not evidence of benefit.
+12 more symptoms
Research Study-type filters use AI-classified labels, audited but not guaranteed — check the paper itself before leaning on one. How we classify this →
709 papers reference this strain in the probiotic database.
Match confidence
How strongly this paper was matched to this strain when the corpus was linked. It orders the list — it says nothing about the study's quality or its findings.
How we classify this →
2026
IN_VITRO
2026
OBSERVATIONAL
2026
OTHER
2025
ANIMAL
2025
ANIMAL
2025
IN_VITRO
2025
OTHER
2025
OTHER
2025
IN_VITRO
2025
IN_VITRO
2025
IN_VITRO
2025
IN_VITRO
2025
OTHER
2025
ANIMAL
2025
IN_VITRO
2025
ANIMAL
2025
ANIMAL
2025
OTHER
2025
OBSERVATIONAL
2025
RCT
Browse all 709 papers →
Probiotic bacteria Bifidobacterium bifidum upregulation of intestinal epithelial tight junction barrier is mediated by TLR-2/TLR-6 receptor complex activation of occludin gene
· npj Biofilms and Microbiomes
Efficacy of probiotics (Bifidobacterium bifidum G9 ‐1) in patients with type 2 diabetes mellitus and chronic kidney disease complicated by constipation: An exploratory, multicenter, open‐label, single‐arm study (BIRDIE study)
· Journal of Diabetes Investigation
ILA-producing bifidobacterium bifidum ameliorates chronic kidney disease via AHR signaling by modulating the gut-kidney axis
· Food Research International
Bifidobacterium bifidum FB3-12 attenuates ovalbumin-induced allergic diseases by enhancing intestinal barrier function and regulating gut microbiota
· npj Science of Food
Bifidobacterium bifidum enhances hepatic mitochondrial β-oxidation and ameliorates MAFLD in a high-fat diet rat model
· Scientific Reports
Structural Diversity of Human Milk Oligosaccharides Mediates Bifidobacterium bifidum-Induced Adhesion to Intestinal Epithelial Cells
· Journal of Agricultural and Food Chemistry
Protective Effects of Bifidobacterium bifidum Strains with IgA-Potentiating Activity Against ETEC Infection in Weanling Mice
· Probiotics and Antimicrobial Proteins
Bifidobacterium bifidum and fucoidan synergistically alleviate D-galactose-induced aging in mice by regulating gut microbiota
· Food Bioscience
Probiotic Bifidobacterium bifidum strains desialylate MUC13 and increase intestinal epithelial barrier function
· Scientific Reports
Effect of chitosan nanoparticles conjugated with the cell free supernatant of Bifidobacterium bifidum on the expression of genes related to colorectal cancer in colon adenocarcinoma (Caco-2) cell line
· BMC Gastroenterology
2′-Fucosyllactose as a prebiotic modulates the probiotic responses of Bifidobacterium bifidum
· Current Research in Food Science
Coculture of Bifidobacterium bifidum G9‐1 With Butyrate‐Producing Bacteria Promotes Butyrate Production
· Microbiology and Immunology
Encapsulation of Bifidobacterium bifidum into a pH-sensitive alginate-pectin gel system using 3D food printing: Enhanced viability and targeted release
· International Journal of Biological Macromolecules
Bifidobacterium bifidum reduces oxidative stress and alters gut flora to mitigate acute liver injury caused by N-acetyl-p-aminophenol
· BMC Microbiology
Characterization of Bifidobacterium bifidum growth and metabolism on whey protein phospholipid concentrate
· Journal of Dairy Science
Bifidobacterium bifidum CCFM1163 alleviates cathartic colon by activating the BDNF-TrkB-PLC/IP 3 pathway to reconstruct the intestinal nerve and barrier
· Food & Function
Bifidobacterium bifidum postbiotics prevent Salmonella Pullorum infection in chickens by modulating pyroptosis and enhancing gut health
· Poultry Science
Structural characterization and immunomodulatory effects of Bifidobacterium bifidum biofilms enriched with extracellular polysaccharides and surface proteins
· International Journal of Biological Macromolecules
Mutualistic interactions between Escherichia coli and Bifidobacterium bifidum enable degradation of human milk oligosaccharides in healthy infants
· bioRxiv (Cold Spring Harbor Laboratory)
Effect of Supplementation with a Specific Probiotic (Bifidobacterium bifidum PRL2010) in Pregnancy for the Prevention of Atopic Dermatitis in Children: Preliminary Results of a Randomized Trial
· Nutrients
Discussion
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Citations
Selected papers that name this strain.
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[1]
PMID 40005000 →Effect of Supplementation with a Specific Probiotic (Bifidobacterium bifidum PRL2010) in Pregnancy for the Prevention of Atopic Dermatitis in Children: Preliminary Results of a Randomized Trial· Nutrients · 2025
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[2]
Source →Mutualistic interactions between Escherichia coli and Bifidobacterium bifidum enable degradation of human milk oligosaccharides in healthy infants· bioRxiv (Cold Spring Harbor Laboratory) · 2025
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[3]
PMID 39064703 →Add-On Bifidobacterium Bifidum Supplement in Children with Attention-Deficit/Hyperactivity Disorder: A 12-Week Randomized Double-Blind Placebo-Controlled Clinical Trial· Nutrients · 2024
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[4]
PMID 37240476 →Effect of Bifidobacterium bifidum G9-1 on the Intestinal Environment and Diarrhea-Predominant Irritable Bowel Syndrome (IBS-D)-like Symptoms in Patients with Quiescent Crohn’s Disease: A Prospective Pilot Study· Journal of Clinical Medicine · 2023
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[5]
PMID 35079761 →A randomised, double-blind, placebo-controlled trial of Bifidobacterium bifidum CCFM16 for manipulation of the gut microbiota and relief from chronic constipation· Food & Function · 2022
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[6]
PMID 34681517 →Improvement in Lactose Tolerance in Hypolactasic Subjects Consuming Ice Creams with High or Low Concentrations of Bifidobacterium bifidum 900791· Foods · 2021
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[7]
PMID 33996367 →Efficacy of Bifidobacterium bifidum G9-1 in improving quality of life in patients with chronic constipation: a prospective intervention study· Bioscience of Microbiota Food and Health · 2021
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[8]
PMID 34631331 →Effects of the intake of non-live Bifidobacterium bifidum on the faecal IgA of full-term infants: a double-blind, randomised, placebo-controlled study· Bioscience of Microbiota Food and Health · 2021
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[9]
PMID 32996156 →Bifidobacterium bifidum TMC3115 ameliorates milk protein allergy in by affecting gut microbiota: A randomized double‐blind control trial· Journal of Food Biochemistry · 2020
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[10]
PMID 29573807 →Bifidobacterium bifidum YIT 10347 fermented milk exerts beneficial effects on gastrointestinal discomfort and symptoms in healthy adults: A double-blind, randomized, placebo-controlled study· Journal of Dairy Science · 2018