Strain Profile
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Bifidobacterium breve MCC1274
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Human-origin
Where this strain was first isolated, curated from the literature and culture-collection catalogs. It describes provenance only — not suitability, and not benefit.
How we classify this →
Sequenced
Whether a public genome assembly is linked for this strain. Without one the genome screens cannot run. It is not a verdict on the organism.
How we classify this →
Public genome assembly available
Bifidobacterium breve MCC1274 has an emerging body of research focused primarily on brain-gut interactions and cognitive health. A 24-week randomized, double-blind, placebo-controlled trial in older adults with suspected mild cognitive impairment examined cognitive function scores and brain atrophy measures as outcomes. Animal studies using APP knock-in mouse models of Alzheimer's disease have examined this strain in relation to amyloid-beta production and microglial activation, including possible metabolite pathways involving tryptophan derivatives and oxidative stress. In vitro work has explored metabolite profiles when the strain is co-cultured with intestinal epithelial cells. These are research topics, not findings; the papers do not establish that this strain treats or prevents any condition.
Where it's been studied Tags come from a conservative keyword scan of each paper's title, abstract, and summary. A tag is research coverage, not measured effect. How we classify this →
Share of this strain's 23 body-system-tagged papers that concern each system. Research coverage, not measured effect.
Symptoms in the research A tag means the paper's text names the symptom or condition — research coverage, not evidence of benefit. How we classify this →
Share of this strain's 2 symptom-tagged papers that mention each symptom or condition. Research coverage, not evidence of benefit.
Research Study-type filters use AI-classified labels, audited but not guaranteed — check the paper itself before leaning on one. How we classify this →
25 papers reference this strain in the probiotic database.
Match confidence
How strongly this paper was matched to this strain when the corpus was linked. It orders the list — it says nothing about the study's quality or its findings.
How we classify this →
2026
ANIMAL
2025
IN_VITRO
2025
REVIEW
2024
ANIMAL
2024
ANIMAL
2024
REVIEW
2024
RCT
2023
IN_VITRO
2023
IN_VITRO
2022
ANIMAL
2022
ANIMAL
2022
IN_VITRO
2022
RCT
2021
ANIMAL
2021
ANIMAL
2021
ANIMAL
2021
RCT
2021
OBSERVATIONAL
2021
RCT
2020
RCT
Browse all 25 papers →
Dietary silver nanoparticle supplementation induces Alzheimer-like lesions through Bifidobacterium deficiency-dominated gut microbiota dysbiosis and neuroinflammation
· npj Science of Food
Effect of the manufacturing process on bifidobacteria survival in ice cream
· Nippon Shokuhin Kagaku Kogaku Kaishi
Protective Effects of Bifidobacterium Breve MCC1274 as a Novel Therapy for Alzheimer’s Disease
· Nutrients
Potential Therapeutic Effects of Bifidobacterium breve MCC1274 on Alzheimer’s Disease Pathologies in AppNL-G-F Mice
· Nutrients
Oral Administration of Probiotic Bifidobacterium breve Ameliorates Tonic–Clonic Seizure in a Pentylenetetrazole-Induced Kindling Mouse Model via Integrin-Linked Kinase Signaling
· International Journal of Molecular Sciences
Extending Healthy Life Expectancy Through the Study of Brain-Gut-Microbiota Axis
· KAGAKU TO SEIBUTSU
Effects of Bifidobacterium longum BB536 and Bifidobacterium breve MCC1274 on Body Composition in Normal and Overweight Adults in Randomized Placebo-Controlled Study
· Nutrients
Comprehensive analysis of metabolites produced by co-cultivation of Bifidobacterium breve MCC1274 with human iPS-derived intestinal epithelial cells
· Frontiers in Microbiology
Probiotic Bifidobacterium breve MCC1274 Protects against Oxidative Stress and Neuronal Lipid Droplet Formation via PLIN4 Gene Regulation
· Microorganisms
Probiotic Bifidobacterium breve MCC1274 Mitigates Alzheimer’s Disease-Related Pathologies in Wild-Type Mice
· Nutrients
Bifidobacterium breve MCC1274 Supplementation Increased the Plasma Levels of Metabolites with Potential Anti-Oxidative Activity in APP Knock-In Mice
· Journal of Alzheimer s Disease
Synbiotics of Bifidobacterium breve MCC1274 and lactulose enhances production of tryptophan metabolites in fermented human fecal communities
· Food Research International
Effect of Probiotic Bifidobacterium breve in Improving Cognitive Function and Preventing Brain Atrophy in Older Patients with Suspected Mild Cognitive Impairment: Results of a 24-Week Randomized, Double-Blind, Placebo-Controlled Trial
· Journal of Alzheimer s Disease
Probiotic Bifidobacterium breve Prevents Memory Impairment Through the Reduction of Both Amyloid-β Production and Microglia Activation in APP Knock-In Mouse
· Journal of Alzheimer s Disease
Oral Administration of Probiotic Bifidobacterium breve Improves Facilitation of Hippocampal Memory Extinction via Restoration of Aberrant Higher Induction of Neuropsin in an MPTP-Induced Mouse Model of Parkinson’s Disease
· Biomedicines
Probiotic Bifidobacterium breve decreases Aβ production via the upregulation of ADAM10 level and attenuates microglia activation in an APP knock‐in mouse model of Alzheimer’s disease
· Alzheimer s & Dementia
Anti‐inflammation as one of the mechanisms in the improvement of cognitive function by probiotic Bifidobacterium breve strain
· Alzheimer s & Dementia
Lipid and Energy Metabolism of the Gut Microbiota Is Associated with the Response to Probiotic Bifidobacterium breve Strain for Anxiety and Depressive Symptoms in Schizophrenia
· Journal of Personalized Medicine
Association of Plasma Hemoglobin A1c with Improvement of Cognitive Functions by Probiotic Bifidobacterium breve Supplementation in Healthy Adults with Mild Cognitive Impairment
· Journal of Alzheimer s Disease
Probiotic Bifidobacterium breve in Improving Cognitive Functions of Older Adults with Suspected Mild Cognitive Impairment: A Randomized, Double-Blind, Placebo-Controlled Trial
· Journal of Alzheimer s Disease
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Citations
Selected papers that name this strain.
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[1]
PMID 41935066 →Dietary silver nanoparticle supplementation induces Alzheimer-like lesions through Bifidobacterium deficiency-dominated gut microbiota dysbiosis and neuroinflammation· npj Science of Food · 2026
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[2]
PMID 33814441 →Association of Plasma Hemoglobin A1c with Improvement of Cognitive Functions by Probiotic Bifidobacterium breve Supplementation in Healthy Adults with Mild Cognitive Impairment· Journal of Alzheimer s Disease · 2021
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[3]
PMID 32623402 →Probiotic Bifidobacterium breve in Improving Cognitive Functions of Older Adults with Suspected Mild Cognitive Impairment: A Randomized, Double-Blind, Placebo-Controlled Trial· Journal of Alzheimer s Disease · 2020