Strain Profile
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Bifidobacterium breve
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Human-origin
Where this strain was first isolated, curated from the literature and culture-collection catalogs. It describes provenance only — not suitability, and not benefit.
How we classify this →
Sequenced
Whether a public genome assembly is linked for this strain. Without one the genome screens cannot run. It is not a verdict on the organism.
How we classify this →
Public genome assembly available
Bifidobacterium breve is a species commonly found in the human gut, particularly in breastfed infants, where it plays a role in fermenting complex carbohydrates including human milk oligosaccharides. Research across multiple B. breve strains has examined metabolism of prebiotic substrates, production of short-chain fatty acids, and immune modulation in animal models. A small early randomized trial examined this strain in the context of Campylobacter enteritis, and in vitro work has characterized metabolic and epithelial cell interactions. Because this index entry is at the species level rather than a specific strain, findings vary considerably across strains and should not be generalized without strain-specific data. These are research topics, not findings; the papers do not establish that this strain treats or prevents any condition.
Where it's been studied Tags come from a conservative keyword scan of each paper's title, abstract, and summary. A tag is research coverage, not measured effect. How we classify this →
Share of this strain's 1,482 body-system-tagged papers that concern each system. Research coverage, not measured effect.
Symptoms in the research A tag means the paper's text names the symptom or condition — research coverage, not evidence of benefit. How we classify this →
Share of this strain's 466 symptom-tagged papers that mention each symptom or condition. Research coverage, not evidence of benefit.
+17 more symptoms
Research Study-type filters use AI-classified labels, audited but not guaranteed — check the paper itself before leaning on one. How we classify this →
2624 papers reference this strain in the probiotic database.
Match confidence
How strongly this paper was matched to this strain when the corpus was linked. It orders the list — it says nothing about the study's quality or its findings.
How we classify this →
2026
ANIMAL
2026
ANIMAL
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ANIMAL
2026
OBSERVATIONAL
2026
ANIMAL
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ANIMAL
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REVIEW
2026
IN_VITRO
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ANIMAL
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IN_VITRO
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OBSERVATIONAL
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ANIMAL
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ANIMAL
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RCT
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RCT
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IN_VITRO
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OTHER
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OTHER
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ANIMAL
2026
ANIMAL
Browse all 2,624 papers →
Dose-related alleviation of cyclophosphamide-induced immunosuppression by Bifidobacterium breve CCFM1310: Involvement of gut barrier restoration and selective MAPK subfamily phosphorylation
· Food Bioscience
Targeting intestinal microbiota with Bifidobacterium breve and Hafnia alvei probiotics does not improve response to influenza vaccine in mice
· Clinical and Experimental Vaccine Research
Bifidobacterium Breve SHMB 8001 Alleviates DSS‐Induced Colitis in Mice Via Modulating the Intestinal Barrier and Gut Microbiota
· Journal of Food Science
Bifidobacterium breve Promotes the Pathogenesis of IBS by Downregulating the Expression of Ferroptosis‐Related Molecule ERBB1: A Mendelian Randomization Mediation Analysis
· Human Mutation
Bifidobacterium Breve Yang08 Alleviates Atopic Dermatitis By Enriching Akkermansia Muciniphila and Inhibiting Neutrophil Extracellular Traps Formation In Mice
· Advanced Science
Bifidobacterium breve and lacto-N-neotetraose mediate gut microbiota-derived acetate to regulate defecation performance and intestinal barrier function in constipated mice
· Journal of Dairy Science
Anti-obesity effects of probiotics beyond BMI: a critical review of human clinical trials
· Letters in Applied Microbiology
Supplementary figure for "Optimized composite cryoprotectants enhance survival and membrane integrity of Bifidobacterium breve BX-18 during lyophilization" manuscript
· Mendeley Data
Bifidobacterium breve Attenuates Depression via IPA-Mediated AHR Signaling and Adult Hippocampal Neurogenesis
· Journal of Future Foods
P1346 Mechanism of free amino acids regulating the metabolic activity of Bifidobacterium breve and promoting intestinal health
· Journal of Crohn s and Colitis
Parental Perception and Experience in Infants with Colic Symptoms Receiving Probiotic Supplementation
· Pediatric Practice and Research
CLA-producing Bifidobacterium breve maintains intestinal immune homeostasis in rat pups through regulating macrophage polarization balance
· Mendeley Data
P1345 Human milk-derived Bifidobacterium breve SHMB 8001 alleviates DSS-induced colitis by restoring intestinal barrier and modulating gut microbiota
· Journal of Crohn s and Colitis
Bifidobacterium breve PRL2020 mitigates antibiotic-induced gut symptoms and dysbiosis in children treated with amoxicillin or amoxicillin-clavulanate
· International Microbiology
Effect of probiotic supplementation on Clostridioides difficile stool concentration in hospitalized patients in coma: A preliminary study
· Polish Annals of Medicine
Saccharomyces cerevisiae Fermentation of Pomegranate Peel By-Product Yields Tannin-Rich Extracts and Potentially Prebiotic Polysaccharides
· Foods
Bifidobacterium breve CCFM1078 alleviates chronic diarrhea in neonatal rats by restoring intestinal motility and barrier function
· Food Bioscience
Evaluation of bifidobacterial fermentation capacity depending on the age of the host
· Electronic Theses and Dissertations Repository (University of Pisa)
Infant-derived Bifidobacterium can enhance the ability to respond to influenza virus infection by promoting type I interferon-mediated immunity
· Food Bioscience
Bifidobacterium breve B2798 ameliorates high-fat diet-induced obesity by reshaping gut microbiota and modulating host metabolic profiles
· Food Science and Human Wellness
Discussion
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Citations
Selected papers that name this strain.
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[1]
PMID 41879960 →The beneficial effect of Bifidobacterium breve Br03 and Bifidobacterium breve B632 mixture in acute infectious diarrhea in children· Probiotics and Antimicrobial Proteins · 2026
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[2]
PMID 42234385 →Bifidobacterium breve PRL2020 mitigates antibiotic-induced gut symptoms and dysbiosis in children treated with amoxicillin or amoxicillin-clavulanate· International Microbiology · 2026
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[3]
PMID 41648756 →Eight weeks of treatment with probiotic Bifidobacterium breve, Bif195 lowers fatigue scores in patients with diarrhoea-predominant irritable bowel syndrome: results from a randomised, clinical trial· Frontiers in Nutrition · 2026
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[4]
PMID 41921070 →Anti-obesity effects of probiotics beyond BMI: a critical review of human clinical trials· Letters in Applied Microbiology · 2026
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[5]
Source →Effect of probiotic supplementation on Clostridioides difficile stool concentration in hospitalized patients in coma: A preliminary study· Polish Annals of Medicine · 2026
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[6]
PMID 41840664 →Efficacy of probiotic-supplemented formula in treating chronic diarrhea in children aged 6–43 months: evidence based on a randomized controlled trial· Gut Pathogens · 2026
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[7]
PMID 41971606 →Multi‐Strain Probiotics BLa80, LRa05, and BBr60 Modulate Inflammation, Bile Acids, and Gut Microbiota in Type 2 Diabetes: A Randomized Controlled Trial· Food Science & Nutrition · 2026
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[8]
PMID 41994268 →The enhancing therapeutic effect of neonatal jaundice by bifidobacterium through regulating inflammation and gut microbiota in combination with phototherapy—a randomized controlled trial· Frontiers in Microbiology · 2026
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[9]
PMID 42020446 →Gut microbiome features associated with Bifidobacterium colonization predict personalized probiotic persistence patterns· Nature Communications · 2026
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[10]
Source →Nourishing the preterm brain: Optimizing nutrition to support neurodevelopment after preterm birth· Utrecht University Repository (Utrecht University) · 2026