Strain Profile
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Bifidobacterium longum R0175
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Human-origin
Where this strain was first isolated, curated from the literature and culture-collection catalogs. It describes provenance only — not suitability, and not benefit.
How we classify this →
Sequenced
Whether a public genome assembly is linked for this strain. Without one the genome screens cannot run. It is not a verdict on the organism.
How we classify this →
Public genome assembly available
Bifidobacterium longum R0175 is most commonly studied as part of a combination formula with Lactobacillus helveticus R0052, and several RCTs using this pair have examined anxiety and psychological well-being in healthy adults. Animal studies have examined liver-related outcomes and behavioral effects, and in vitro work has examined gut-epithelial interactions and the metabolomic profile of the strain's secretome. A 2024 RCT in patients with mild-to-moderate Alzheimer's disease, using a multi-strain blend including R0175, examined oxidative stress markers, though isolating the contribution of this specific strain from combination data is not possible. Most human data on R0175 come from multi-strain contexts rather than this strain in isolation. These are research topics, not findings; the papers do not establish that this strain treats or prevents any condition.
Where it's been studied Tags come from a conservative keyword scan of each paper's title, abstract, and summary. A tag is research coverage, not measured effect. How we classify this →
Share of this strain's 46 body-system-tagged papers that concern each system. Research coverage, not measured effect.
+1 more systems
Symptoms in the research A tag means the paper's text names the symptom or condition — research coverage, not evidence of benefit. How we classify this →
Share of this strain's 28 symptom-tagged papers that mention each symptom or condition. Research coverage, not evidence of benefit.
+3 more symptoms
Research Study-type filters use AI-classified labels, audited but not guaranteed — check the paper itself before leaning on one. How we classify this →
60 papers reference this strain in the probiotic database.
Match confidence
How strongly this paper was matched to this strain when the corpus was linked. It orders the list — it says nothing about the study's quality or its findings.
How we classify this →
2025
RCT
2025
OTHER
2025
ANIMAL
2025
RCT
2025
IN_VITRO
2024
RCT
2023
ANIMAL
2023
OBSERVATIONAL
2023
RCT
2023
IN_VITRO
2022
IN_VITRO
2022
RCT
2021
OBSERVATIONAL
2020
RCT
2020
ANIMAL
2019
ANIMAL
2017
IN_VITRO
2016
IN_VITRO
2015
RCT
2014
IN_VITRO
Browse all 60 papers →
A Randomized Controlled Trial Evaluating the Effects of a Probiotic Containing Lactobacillus helveticus R0052 and Bifidobacterium longum R0175 on Gastrointestinal Symptoms and Metabolomic Profiles in Female Dancers
· International Journal of Molecular Sciences
Metabolomic Signatures of Probiotic Secretomes Reveal Strain-Specific Biofunctional Potential: Insights from Lacticaseibacillus rhamnosus R0011 and Bifidobacterium longum R0175
· Borealis
Influence of dietary supplementation with two distinct probiotic strains, Bifidobacterium longum R0175 and Lacticaseibacillus rhamnosus JB-1, on seizure susceptibility and valproate response: Behavioral and biochemical studies in mice
· Nutrition
Strain specific effects of probiotic supplementation on serum amino acid profiles in Alzheimer’s disease: a randomized, double blind, placebo controlled trial
· Scientific Reports
Probiotic secretomes and prebiotics modulate the adverse effects of polychlorinated biphenyls on in vitro intestinal outcomes
· Open MIND
The effects of probiotic supplements on oxidative stress and inflammation in subjects with mild and moderate Alzheimer’s disease: a randomized, double-blind, placebo-controlled study
· Inflammopharmacology
Bifidobacterium longum R0175 protects mice against APAP-induced liver injury by modulating the Nrf2 pathway
· Free Radical Biology and Medicine
USE OF PROBIOTICS IN ALLERGIC RHINITS: A PILOT STUDY
· Journal of Contemporary Diseases and Advanced Medicine
Psychobiotic Effects on Anxiety Are Modulated by Lifestyle Behaviors: A Randomized Placebo-Controlled Trial on Healthy Adults
· Nutrients
Evidence of the Dysbiotic Effect of Psychotropics on Gut Microbiota and Capacity of Probiotics to Alleviate Related Dysbiosis in a Model of the Human Colon
· International Journal of Molecular Sciences
Effect of probiotic bacteria on porcine rotavirus OSU infection of porcine intestinal epithelial IPEC-J2 cells
· Archives of Virology
Effects of probiotic supplements on cognition, anxiety, and physical activity in subjects with mild and moderate Alzheimer’s disease: A randomized, double-blind, and placebo-controlled study
· Frontiers in Aging Neuroscience
The Efficacy, Safety, and Tolerability of Probiotics on Depression: Clinical Results From an Open-Label Pilot Study
· Frontiers in Psychiatry
Efficacy of Lactobacillus paracasei HA-196 and Bifidobacterium longum R0175 in Alleviating Symptoms of Irritable Bowel Syndrome (IBS): A Randomized, Placebo-Controlled Study
· Nutrients
Bifidobacterium longum R0175 Protects Rats against d-Galactosamine-Induced Acute Liver Failure
· mSphere
Bifidobacterium longum R0175 attenuates post-myocardial infarction depressive-like behaviour in rats
· PLoS ONE
Impact des procédés de fabrication des yogourts de type grec sur les communautés microbiennes durant l'entreposage
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Catabolism of citrus flavanones by the probiotics Bifidobacterium longum and Lactobacillus rhamnosus
· European Journal of Nutrition
Chronic administration of a microencapsulated probiotic enhances the bioavailability of orange juice flavanones in humans
· Free Radical Biology and Medicine
Membrane fatty acid composition and fluidity are involved in the resistance to freezing of Lactobacillus buchneri R 1102 and Bifidobacterium longum R 0175
· Microbial Biotechnology
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Citations
Selected papers that name this strain.
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[1]
PMID 40817120 →Strain specific effects of probiotic supplementation on serum amino acid profiles in Alzheimer’s disease: a randomized, double blind, placebo controlled trial· Scientific Reports · 2025
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[2]
PMID 36389063 →Effects of probiotic supplements on cognition, anxiety, and physical activity in subjects with mild and moderate Alzheimer’s disease: A randomized, double-blind, and placebo-controlled study· Frontiers in Aging Neuroscience · 2022
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[3]
PMID 32326347 →Efficacy of Lactobacillus paracasei HA-196 and Bifidobacterium longum R0175 in Alleviating Symptoms of Irritable Bowel Syndrome (IBS): A Randomized, Placebo-Controlled Study· Nutrients · 2020
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[4]
PMID 20974015 →Assessment of psychotropic-like properties of a probiotic formulation (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in rats and human subjects· British Journal Of Nutrition · 2010