Body system

Brain & Mood

Gut-brain axis, neuroactive metabolite production.

Strains with relevant research

top 24 of 444 by paper count

Selected by genome rollups and papers whose text names this body system, and ranked by how many of each strain's linked papers name it. This is research coverage from the corpus — not evidence that a strain benefits brain & mood.

Akkermansia muciniphila

Akkermansia muciniphila is a gut bacterium that naturally inhabits the mucus layer lining the intestine and has attracted substantial scientific interest as a potential next-generation probiotic.

Barrier Metabolic Immune
◔ Human-origin
3291 papers 0 comments

Lactiplantibacillus plantarum

Lactiplantibacillus plantarum (formerly Lactobacillus plantarum) is a well-characterized lactic acid bacterium found across fermented foods, the human gut, and diverse environmental niches.

Metabolic Survival Immune
◐ Food-origin
15757 papers 0 comments

Bifidobacterium longum

Bifidobacterium longum is a well-characterized commensal species found throughout the human gut, with a particularly studied role in early-life microbiome establishment.

Metabolic Barrier Immune
◔ Human-origin
3793 papers 0 comments

Lacticaseibacillus rhamnosus

Lacticaseibacillus rhamnosus, most widely studied as the GG strain, has an extensive research record, though the evidence base in this index is predominantly in vitro and animal-model work.

Survival Metabolic Immune
◐ Food-origin
5597 papers 0 comments

Lactobacillus acidophilus

Lactobacillus acidophilus is one of the most studied lactic acid bacteria, with research dating back decades documenting its ability to survive the harsh conditions of the gastrointestinal tract, including acid and bile …

Survival Metabolic Immune
◐ Food-origin
16417 papers 0 comments

Bifidobacterium breve

Bifidobacterium breve is a species commonly found in the human gut, particularly in breastfed infants, where it plays a role in fermenting complex carbohydrates including human milk oligosaccharides.

Metabolic Immune Barrier
◔ Human-origin
2624 papers 0 comments

Lacticaseibacillus rhamnosus GG

™ GG
ATCC 53103

Lacticaseibacillus rhamnosus GG (LGG) is one of the most extensively studied probiotic strains globally, though the papers linked to this strain entry focus primarily on encapsulation technology and formulation stability…

Barrier Immune Adhesion
◐ Food-origin
3593 papers 0 comments

Lactobacillus casei

Lactobacillus casei (species-level entry, undesignated strain) is a broadly studied lactic acid bacterium encountered across fermented dairy and non-dairy foods.

Survival Metabolic Immune
◐ Food-origin
13899 papers 0 comments

Lactobacillus helveticus

Lactobacillus helveticus is a lactic acid bacterium widely used in dairy fermentation and probiotic applications.

Metabolic Survival Immune
◐ Food-origin
3431 papers 0 comments

Lactobacillus brevis

Lactobacillus brevis is a heterofermentative lactic acid bacterium widely distributed in fermented food environments.

Metabolic Survival Precision
◐ Food-origin
4899 papers 0 comments

Faecalibacterium prausnitzii

Faecalibacterium prausnitzii is a butyrate-producing commensal bacterium that is among the most abundant in a healthy human gut and has attracted significant research interest as a potential next-generation probiotic.

Barrier Metabolic Immune
◔ Human-origin
1279 papers 0 comments

Lacticaseibacillus paracasei

Lacticaseibacillus paracasei (the species, without a designated strain identifier) is a broadly distributed lactic acid bacterium found in fermented foods and the human gut.

Metabolic Survival Immune
◐ Food-origin
3350 papers 0 comments

Bifidobacterium infantis

Bifidobacterium infantis is an anaerobic bacterium native to the infant gut microbiota.

Barrier Immune Metabolic
◔ Human-origin
1349 papers 0 comments

Clostridium butyricum

Clostridium butyricum is a spore-forming anaerobic bacterium capable of producing butyric acid through fermentation.

Metabolic Immune Barrier
◑ Environmental
3072 papers 0 comments

Lactobacillus johnsonii

Lactobacillus johnsonii is a facultative anaerobic lactic acid bacterium originally isolated from the human vaginal microbiota.

Immune Barrier Metabolic
◐ Food-origin
1396 papers 0 comments

Limosilactobacillus reuteri DSM 17938

DSM 17938

Limosilactobacillus reuteri DSM 17938 (formerly Lactobacillus reuteri DSM 17938) has been studied in multiple randomized controlled trials and at least one published meta-analysis examining infantile colic, episodes of p…

Barrier Immune Adhesion
◔ Human-origin
578 papers 0 comments

Streptococcus iniae

Streptococcus iniae is a fish pathogen primarily associated with disease in farmed and wild fish, particularly tilapia, and is recognized as a zoonotic agent — it has caused invasive infections in humans who handle fish,…

Immune Precision Safety
◔ Human-origin
639 papers 0 comments

Lacticaseibacillus casei

Lacticaseibacillus casei (species-level entry, no specific strain designation) is a broad species grouping that includes well-studied commercial strains such as L.

Survival Metabolic Immune
◐ Food-origin
6175 papers 0 comments

Escherichia coli Nissle 1917

™ Nissle 1917

Escherichia coli Nissle 1917 (EcN) is a non-pathogenic E.

Barrier Immune Adhesion
◔ Human-origin
1483 papers 0 comments

Bacteroides thetaiotaomicron

Bacteroides thetaiotaomicron is a dominant member of the healthy human gut microbiome and one of the most extensively studied gut commensal bacteria.

Metabolic Adhesion Survival
◔ Human-origin
1680 papers 0 comments

Bacteroides uniformis

Bacteroides uniformis is a common anaerobic bacterium of the human gut microbiome, and a specific strain (CECT 7771) has attracted research interest for its metabolic effects in animal models.

Metabolic Barrier Immune
◔ Human-origin
540 papers 0 comments

Lactobacillus helveticus R0052

™ R0052

Lactobacillus helveticus R0052 is most often studied in combination with Bifidobacterium longum R0175, a pairing investigated in the context of the gut-brain axis (the bidirectional communication network linking intestin…

Immune Barrier Adhesion
◐ Food-origin
128 papers 0 comments

Bifidobacterium longum R0175

™ R0175

Bifidobacterium longum R0175 is most commonly studied as part of a combination formula with Lactobacillus helveticus R0052, and several RCTs using this pair have examined anxiety and psychological well-being in healthy a…

Immune Barrier Metabolic
◔ Human-origin
60 papers 0 comments

Bifidobacterium bifidum

Bifidobacterium bifidum is a species naturally present in the human gut, particularly abundant in breastfed infants, where it plays a role in fermenting complex carbohydrates, including human milk oligosaccharides and ce…

Metabolic Survival Barrier
◔ Human-origin
709 papers 0 comments