Strain Profile
· NCBI Strain Taxon
353496
NCBI Taxonomy's node for this specific strain. A different identifier from the culture-collection deposit numbers below, which name a physical stock rather than a taxonomic node.
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Lactobacillus delbrueckii subsp. bulgaricus 2038
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Food-origin
Where this strain was first isolated, curated from the literature and culture-collection catalogs. It describes provenance only — not suitability, and not benefit.
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Sequenced
Whether a public genome assembly is linked for this strain. Without one the genome screens cannot run. It is not a verdict on the organism.
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Public genome assembly available
Lactobacillus delbrueckii subsp. bulgaricus 2038 is a yogurt starter strain typically used in combination with Streptococcus thermophilus 1131, and research on this pair spans in vitro, animal, and early human studies. In vitro work using human intestinal cell models has examined the combination in relation to gut barrier function and cellular energy-sensing pathways (AMPK), and a 2026 in vitro study examined these strains in relation to the uptake of polystyrene nanoplastics by intestinal epithelial cells, in research that has not been replicated in humans. Animal studies have examined this combination in relation to gut-associated immune cell activity. Human evidence is limited to an observational lactose-tolerance study; strain-specific clinical trial data are not yet available. These are research topics, not findings; the papers do not establish that this strain treats or prevents any condition.
Where it's been studied Tags come from a conservative keyword scan of each paper's title, abstract, and summary. A tag is research coverage, not measured effect. How we classify this →
Share of this strain's 11 body-system-tagged papers that concern each system. Research coverage, not measured effect.
Symptoms in the research A tag means the paper's text names the symptom or condition — research coverage, not evidence of benefit. How we classify this →
Share of this strain's 1 symptom-tagged papers that mention each symptom or condition. Research coverage, not evidence of benefit.
Research Study-type filters use AI-classified labels, audited but not guaranteed — check the paper itself before leaning on one. How we classify this →
25 papers reference this strain in the probiotic database.
Match confidence
How strongly this paper was matched to this strain when the corpus was linked. It orders the list — it says nothing about the study's quality or its findings.
How we classify this →
2026
IN_VITRO
2026
IN_VITRO
2025
IN_VITRO
2023
IN_VITRO
2019
ANIMAL
2018
ANIMAL
1992
OBSERVATIONAL
2025
IN_VITRO
2019
ANIMAL
2015
WGS
2001
IN_VITRO
2000
ANIMAL
1998
ANIMAL
2025
IN_VITRO
2025
IN_VITRO
2025
IN_VITRO
2025
IN_VITRO
2025
IN_VITRO
2025
IN_VITRO
2016
IN_VITRO
Browse all 25 papers →
Lactobacillus delbrueckii subsp. bulgaricus 2038 and Streptococcus thermophilus 1131 suppress polystyrene nanoplastic transcellular permeability and internalization by intestinal epithelial cells
· Scientific Reports
Streptococcus thermophilus 1131 and Lactobacillus delbrueckii subsp. bulgaricus 2038 induce immune responses via M cell-mediated transcytosis in an in vitro human gut model
· Journal of Applied Microbiology
Lactobacillus delbrueckii subsp. bulgaricus 2038 and Streptococcus thermophilus 1131 ameliorate barrier dysfunction in human induced pluripotent stem cell-derived crypt-villus structural small intestine
· Frontiers in Immunology
Yogurt starter strains ameliorate intestinal barrier dysfunction via activating AMPK in Caco-2 cells
· Tissue Barriers
Lactobacillus delbrueckii subsp. bulgaricus 2038 and Streptococcus thermophilus 1131 Induce the Expression of the REG3 Family in the Small Intestine of Mice via the Stimulation of Dendritic Cells and Type 3 Innate Lymphoid Cells
· Nutrients
Effects of long-term intake of a yogurt fermented with Lactobacillus delbrueckii subsp. bulgaricus 2038 and Streptococcus thermophilus 1131 on mice
· International Immunology
Differences in Breath Hydrogen Excretion and Abdominal Symptoms after Ingestion of Milk and Yogurt by Lactose-intolerant Individuals.
· Nippon Eiyo Shokuryo Gakkaishi
Supplementary file 1_Lactobacillus delbrueckii subsp. bulgaricus 2038 and Streptococcus thermophilus 1131 ameliorate barrier dysfunction in human induced pluripotent stem cell-derived crypt-villus structural small intestine.docx
· Figshare
Effects of Long-Term Intake of Fermented Milk Containing Lactobacillus delbrueckii subsp. bulgaricus 2038 and Streptococcus thermophilus 1131 on Mice
Lactobacillus delbrueckii subsp. bulgaricus 2038とStreptococcus thermophilus 1131を含む発酵乳の長期摂取がマウスに及ぼす影響
· Institutional Repositories DataBase (IRDB)
Strand-specific RNA-seq analysis of the Lactobacillus delbrueckii subsp. bulgaricus transcriptome
· Molecular BioSystems
Prevention by Lactic Acid Bacteria of the Oxidation of Human LDL
· Bioscience Biotechnology and Biochemistry
Preventive Effect of Lactobacillus delbrueckii subsp. bulgaricus on the Oxidation of LDL
· Bioscience Biotechnology and Biochemistry
Effects of Lactic Acid Bacteria on Binding and Absorption of Mutagenic Heterocyclic Amines
· Bioscience Biotechnology and Biochemistry
Image 2_Lactobacillus delbrueckii subsp. bulgaricus 2038 and Streptococcus thermophilus 1131 ameliorate barrier dysfunction in human induced pluripotent stem cell-derived crypt-villus structural small intestine.tif
· Figshare
Image 4_Lactobacillus delbrueckii subsp. bulgaricus 2038 and Streptococcus thermophilus 1131 ameliorate barrier dysfunction in human induced pluripotent stem cell-derived crypt-villus structural small intestine.tif
· Figshare
Image 3_Lactobacillus delbrueckii subsp. bulgaricus 2038 and Streptococcus thermophilus 1131 ameliorate barrier dysfunction in human induced pluripotent stem cell-derived crypt-villus structural small intestine.tif
· Figshare
Image 1_Lactobacillus delbrueckii subsp. bulgaricus 2038 and Streptococcus thermophilus 1131 ameliorate barrier dysfunction in human induced pluripotent stem cell-derived crypt-villus structural small intestine.tif
· Figshare
Image 6_Lactobacillus delbrueckii subsp. bulgaricus 2038 and Streptococcus thermophilus 1131 ameliorate barrier dysfunction in human induced pluripotent stem cell-derived crypt-villus structural small intestine.tif
· Figshare
Image 5_Lactobacillus delbrueckii subsp. bulgaricus 2038 and Streptococcus thermophilus 1131 ameliorate barrier dysfunction in human induced pluripotent stem cell-derived crypt-villus structural small intestine.tif
· Figshare
Relationship between Lactobacillus bulgaricus and Streptococcus thermophilus under whey conditions: Focus on amino acid formation
· International Dairy Journal
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Citations
Selected papers that name this strain.
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[1]
PMID 42397132 →Streptococcus thermophilus 1131 and Lactobacillus delbrueckii subsp. bulgaricus 2038 induce immune responses via M cell-mediated transcytosis in an in vitro human gut model· Journal of Applied Microbiology · 2026
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[2]
PMID 41691046 →Lactobacillus delbrueckii subsp. bulgaricus 2038 and Streptococcus thermophilus 1131 suppress polystyrene nanoplastic transcellular permeability and internalization by intestinal epithelial cells· Scientific Reports · 2026
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[3]
Source →Differences in Breath Hydrogen Excretion and Abdominal Symptoms after Ingestion of Milk and Yogurt by Lactose-intolerant Individuals.· Nippon Eiyo Shokuryo Gakkaishi · 1992