Strain Profile
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Bifidobacterium breve BR03
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Human-origin
Where this strain was first isolated, curated from the literature and culture-collection catalogs. It describes provenance only — not suitability, and not benefit.
How we classify this →
Sequenced
Whether a public genome assembly is linked for this strain. Without one the genome screens cannot run. It is not a verdict on the organism.
How we classify this →
Public genome assembly available
Bifidobacterium breve BR03 is a named probiotic strain studied in randomized controlled trials spanning multiple research contexts. Human RCTs have examined this strain, often in combination with companion strains, in relation to metabolic parameters in pediatric obesity, intestinal colonization, and immune-related conditions such as celiac disease and atopic dermatitis. Preliminary clinical work has also examined infant colic and traveler's gastrointestinal symptoms as research topics. These are research topics, not findings; the papers do not establish that this strain treats or prevents any condition.
Where it's been studied Tags come from a conservative keyword scan of each paper's title, abstract, and summary. A tag is research coverage, not measured effect. How we classify this →
Share of this strain's 27 body-system-tagged papers that concern each system. Research coverage, not measured effect.
+2 more systems
Symptoms in the research A tag means the paper's text names the symptom or condition — research coverage, not evidence of benefit. How we classify this →
Share of this strain's 15 symptom-tagged papers that mention each symptom or condition. Research coverage, not evidence of benefit.
Research Study-type filters use AI-classified labels, audited but not guaranteed — check the paper itself before leaning on one. How we classify this →
32 papers reference this strain in the probiotic database.
Match confidence
How strongly this paper was matched to this strain when the corpus was linked. It orders the list — it says nothing about the study's quality or its findings.
How we classify this →
2026
RCT
2026
OBSERVATIONAL
2026
OBSERVATIONAL
2025
RCT
2025
OBSERVATIONAL
2022
RCT
2022
IN_VITRO
2021
RCT
2020
RCT
2019
IN_VITRO
2019
WGS
2018
RCT
2017
RCT
2016
RCT
2016
RCT
2016
RCT
2016
RCT
2016
OBSERVATIONAL
2015
IN_VITRO
2014
OBSERVATIONAL
Browse all 32 papers →
The beneficial effect of Bifidobacterium breve Br03 and Bifidobacterium breve B632 mixture in acute infectious diarrhea in children
· Probiotics and Antimicrobial Proteins
A Multi-Target Symbiotic Formulation Reduces Recurrence in Recurrent Bacterial Vaginosis and Vulvovaginal Candidiasis: A Pilot Clinical Study
· Open Journal of Obstetrics and Gynecology
Parental Perception and Experience in Infants with Colic Symptoms Receiving Probiotic Supplementation
· Pediatric Practice and Research
Effect of Bifidobacterium Breve on Lipid Profile and Body Fat Reduction in Patients with Metabolic Syndrome: A Randomized, Double-Blind, Placebo-Controlled, Clinical Trial
· Journal of Current Science and Technology
Prevention of Traveler's Diarrhea while Crossing the Amazon Rainforest by Bike with a Supplement Based on Lacticaseibacillus Rhamnosus LR04 (DSM 16605) + Streptococcus Thermophilus FP4 (DSM 18616) + Bifidobacterium Brevis BR03 (DSM 16604): a Phase Two, Randomized, Placebo-controlled, Double-blind, Cross-over Pilot Study
· Top Italian Scientists Journal
Facial Acne: A Randomized, Double-Blind, Placebo-Controlled Study on the Clinical Efficacy of a Symbiotic Dietary Supplement
· Dermatology and Therapy
The Gut-Ex-Vivo System (GEVS) Is a Dynamic and Versatile Tool for the Study of DNBS-Induced IBD in BALB/C and C57BL/6 Mice, Highlighting the Protective Role of Probiotics
· Biology
Supplementation with Bifidobacterium breve BR03 and B632 strains improved insulin sensitivity in children and adolescents with obesity in a cross-over, randomized double-blind placebo-controlled trial
· Clinical Nutrition
Supplementation with Bifidobacterium breve BR03 and Bifidobacterium breve B632 favoured weight loss and improved insulin metabolism in children and adolescents with obesity in the BIFI-OBESE cross-over, randomized placebo-controlled trial
· Endocrine Abstracts
A Systematic Evaluation of the Immunomodulatory and Functional Properties of Probiotic Bifidobacterium breve BR03 (DSM 16604) Lactobacillus plantarum LP01 (LMG P-21021)
· Journal of Probiotics & Health
Single-Scaffold Genome Sequence of Probiotic Strain Bifidobacterium breve BR03 (DSM 16604), Obtained by Combining Hybrid Sequencing and Optical Mapping
· Microbiology Resource Announcements
Clinical intervention using Bifidobacterium strains in celiac disease children reveals novel microbial modulators of TNF-α and short-chain fatty acids
· Clinical Nutrition
Effetti della supplementazione con probiotici sull’attività antiossidante plasmatica in calciatori di élite
· The Journal of Sport and Anatomy
Vpliv probiotika Bidifobacterium breve BR03 na raven provnetnih in protivnetnih citokinov ter kratkoverižnih maščobnih kislin pri otrocih s celiakijo
· University of Maribor digital library (University of Maribor)
Can Probiotics Reduce Diarrhea and Infant Mortality in Africa?
· Journal of Clinical Gastroenterology
Probiotic Streptococcus thermophilus FP4 and Bifidobacterium breve BR03 Supplementation Attenuates Performance and Range-of-Motion Decrements Following Muscle Damaging Exercise
· Nutrients
The Association of Bifidobacterium breve BR03 and B632 is Effective to Prevent Colics in Bottle-fed Infants
· Journal of Clinical Gastroenterology
Probiotics and refractory chronic spontaneous urticaria.
· PubMed
Immunomodulatory Effects of Lactobacillus salivarius LS01 and Bifidobacterium breve BR03, Alone and in Combination, on Peripheral Blood Mononuclear Cells of Allergic Asthmatics
· Allergy Asthma and Immunology Research
Capability of the Two Microorganisms Bifidobacterium breve B632 and Bifidobacterium breve BR03 to Colonize the Intestinal Microbiota of Children
· Journal of Clinical Gastroenterology
Discussion
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Citations
Selected papers that name this strain.
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[1]
PMID 41879960 →The beneficial effect of Bifidobacterium breve Br03 and Bifidobacterium breve B632 mixture in acute infectious diarrhea in children· Probiotics and Antimicrobial Proteins · 2026
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[2]
Source →Effect of Bifidobacterium Breve on Lipid Profile and Body Fat Reduction in Patients with Metabolic Syndrome: A Randomized, Double-Blind, Placebo-Controlled, Clinical Trial· Journal of Current Science and Technology · 2025
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[3]
PMID 35061237 →Facial Acne: A Randomized, Double-Blind, Placebo-Controlled Study on the Clinical Efficacy of a Symbiotic Dietary Supplement· Dermatology and Therapy · 2022
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[4]
PMID 34229263 →Supplementation with Bifidobacterium breve BR03 and B632 strains improved insulin sensitivity in children and adolescents with obesity in a cross-over, randomized double-blind placebo-controlled trial· Clinical Nutrition · 2021
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[5]
PMID 27741166 →The Association of Bifidobacterium breve BR03 and B632 is Effective to Prevent Colics in Bottle-fed Infants· Journal of Clinical Gastroenterology · 2016
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[6]
Source →Vpliv probiotika Bidifobacterium breve BR03 na raven provnetnih in protivnetnih citokinov ter kratkoverižnih maščobnih kislin pri otrocih s celiakijo· University of Maribor digital library (University of Maribor) · 2016
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[7]
PMID 27754427 →Probiotic Streptococcus thermophilus FP4 and Bifidobacterium breve BR03 Supplementation Attenuates Performance and Range-of-Motion Decrements Following Muscle Damaging Exercise· Nutrients · 2016
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[8]
PMID 22955355 →Probiotics Reduce Gut Microbial Translocation and Improve Adult Atopic Dermatitis· Journal of Clinical Gastroenterology · 2012
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[9]
PMID 20697291 →The Use of Probiotics in Healthy Volunteers With Evacuation Disorders and Hard Stools· Journal of Clinical Gastroenterology · 2010