Strain Profile · NCBI Strain Taxon 206672
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Bifidobacterium longum NCC2705

DEP NCC2705
◔ Human-origin
Sequenced
Public genome assembly available

Bifidobacterium longum NCC2705 is a well-characterized probiotic strain whose complete genome has been sequenced and studied extensively, providing a detailed picture of how it colonizes and persists in the gut. Research in animal models has examined immune-related markers, including one mouse study examining gluten-related gut inflammation, and in vitro work has characterized bile-resistance mechanisms relevant to digestive transit, documented in laboratory settings. The bulk of strain-specific evidence remains at the laboratory or animal level; human clinical data for this particular strain are limited, and its effects in people have not been established by controlled trials. These are research topics, not findings; the papers do not establish that this strain treats or prevents any condition.

Where it's been studied

Share of this strain's 35 body-system-tagged papers that concern each system. Research coverage, not measured effect.

+2 more systems

Symptoms in the research

Share of this strain's 5 symptom-tagged papers that mention each symptom or condition. Research coverage, not evidence of benefit.

+1 more symptoms

Research

64 papers reference this strain in the probiotic database.

Match confidence
2021 OTHER
Characterization of the Hydrogen Peroxide Stress Responses of Bifidobacterium longum and Bifidobacterium animalis subsp. Lactis
· Digital Commons - USU (Utah State University)
2018 IN_VITRO
Protease signaling through protease activated receptor 1 mediate nerve activation by mucosal supernatants from irritable bowel syndrome but not from ulcerative colitis patients
· PLoS ONE
2017 ANIMAL
A Commensal Bifidobacterium longum Strain Prevents Gluten-Related Immunopathology in Mice through Expression of a Serine Protease Inhibitor
· Applied and Environmental Microbiology
2015 WGS
Additional file 1: Figure S1. of Pangenome analysis of Bifidobacterium longum and site-directed mutagenesis through by-pass of restriction-modification systems
· Figshare
2012 ANIMAL
The Impact of Bifidobacterium bifidum and its Surface Protein BopA on the Murine Intestinal Barrier and Endogenous Microbiota Composition
· TSpace (University of Toronto)
2011 IN_VITRO
Controlled Gene Expression in Bifidobacteria by Use of a Bile-Responsive Element
· Applied and Environmental Microbiology
2010 IN_VITRO
Construction of a Novel E.coli-Bifidobacterium Shuttle Vector
· Zhongguo shengwu huaxue yu fenzi shengwu xuebao
2010 IN_VITRO
New method for selection of hydrogen peroxide adapted bifidobacteria cells using continuous culture and immobilized cell technology
· Microbial Cell Factories
2009 IN_VITRO
HspR Mutations Are Naturally Selected in Bifidobacterium longum When Successive Heat Shock Treatments Are Applied
· Journal of Bacteriology
2009 IN_VITRO
Bile-Inducible Efflux Transporter from Bifidobacterium longum NCC2705, Conferring Bile Resistance
· Applied and Environmental Microbiology
2009 ANIMAL
A Mesocosm of Lactobacillus johnsonii, Bifidobacterium longum, and Escherichia coli in the Mouse Gut
· DNA and Cell Biology
2008 WGS
Comparative genomic analysis of the gut bacterium Bifidobacterium longum reveals loci susceptible to deletion during pure culture growth
· BMC Genomics
2007 IN_VITRO
Global transcriptome analysis of the heat shock response of Bifidobacterium longum
· FEMS Microbiology Letters
2007 ANIMAL
Gnotobiotic Mouse Immune Response Induced by Bifidobacterium sp. Strains Isolated from Infants
· Applied and Environmental Microbiology
2007 IN_VITRO
Analysis of Host-Inducing Proteome Changes in Bifidobacterium longum NCC2705 Grown in Vivo
· Journal of Proteome Research
2006 WGS
Sugar Transport Systems of Bifidobacterium longum NCC2705
· Microbial Physiology
2006 IN_VITRO
A Serpin from the Gut Bacterium Bifidobacterium longum Inhibits Eukaryotic Elastase-like Serine Proteases
· Journal of Biological Chemistry
2005 IN_VITRO
Bifidobacterium longum Endogalactanase Liberates Galactotriose from Type I Galactans
· Applied and Environmental Microbiology
2005 WGS
Lessons from the genomes of bifidobacteria
· FEMS Microbiology Reviews
2021 REVIEW
SARS-CoV-2 Infection and Microbiota Alterations; Potential Beneficial Roles of Probiotics: A Review Article
· International Journal of Enteric Pathogens
Browse all 64 papers →

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Citations

Selected papers that name this strain.

  1. [1]
    A Commensal Bifidobacterium longum Strain Prevents Gluten-Related Immunopathology in Mice through Expression of a Serine Protease Inhibitor
    · Applied and Environmental Microbiology · 2017
    PMID 28778891 →
  2. [2]
    Comparative genomic analysis of the gut bacterium Bifidobacterium longum reveals loci susceptible to deletion during pure culture growth
    · BMC Genomics · 2008
    PMID 18505588 →
  3. [3]
    Gnotobiotic Mouse Immune Response Induced by Bifidobacterium sp. Strains Isolated from Infants
    · Applied and Environmental Microbiology · 2007
    PMID 18083875 →