Strain Profile
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Bifidobacterium longum
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Human-origin
Where this strain was first isolated, curated from the literature and culture-collection catalogs. It describes provenance only — not suitability, and not benefit.
How we classify this →
Sequenced
Whether a public genome assembly is linked for this strain. Without one the genome screens cannot run. It is not a verdict on the organism.
How we classify this →
Public genome assembly available
Bifidobacterium longum is a well-characterized commensal species found throughout the human gut, with a particularly studied role in early-life microbiome establishment. The available evidence base for this strain is early-stage and varied: in vitro studies have explored enzyme activity, sulfur metabolism, and colon cancer cell lines, while animal model research has examined gut barrier function and inflammatory cytokines in colitis contexts. One observational study examines how diet and milk glycans influence B. longum subspecies dynamics in the infant gut microbiome. No human clinical trials appear in this strain's evidence set. These are research topics, not findings; the papers do not establish that this strain treats or prevents any condition.
Where it's been studied Tags come from a conservative keyword scan of each paper's title, abstract, and summary. A tag is research coverage, not measured effect. How we classify this →
Share of this strain's 2,472 body-system-tagged papers that concern each system. Research coverage, not measured effect.
Symptoms in the research A tag means the paper's text names the symptom or condition — research coverage, not evidence of benefit. How we classify this →
Share of this strain's 827 symptom-tagged papers that mention each symptom or condition. Research coverage, not evidence of benefit.
+17 more symptoms
Research Study-type filters use AI-classified labels, audited but not guaranteed — check the paper itself before leaning on one. How we classify this →
3793 papers reference this strain in the probiotic database.
Match confidence
How strongly this paper was matched to this strain when the corpus was linked. It orders the list — it says nothing about the study's quality or its findings.
How we classify this →
IN_VITRO
IN_VITRO
OTHER
REVIEW
2026
OTHER
2026
ANIMAL
2026
ANIMAL
2026
REVIEW
2026
ANIMAL
2026
ANIMAL
2026
ANIMAL
2026
ANIMAL
2026
ANIMAL
2026
IN_VITRO
2026
ANIMAL
2026
IN_VITRO
2026
ANIMAL
2026
WGS
2026
OTHER
2026
IN_VITRO
Browse all 3,793 papers →
Development of Novel Prebiotics Targeting the Unique Plant Polysaccharide Metabolism System of Bifidobacterium
ビフィズス菌の特異な植物多糖代謝系をターゲットにした新規プレバイオティクスの創製
· Institutional Repositories DataBase (IRDB)
Analysis of Glycoside Hydrolase Enzymes Involved in the β-Arabino-Oligosaccharide Metabolic Pathway of Bifidobacteria
ビフィズス菌のβ-アラビノオリゴ糖鎖代謝機構に関わる糖質分解酵素群の解析
· Institutional Repositories DataBase (IRDB)
Probiotic Properties of a Composition of Indigenous Strains Bifidobacterium bifidum ICIS-310 and Bifidobacterium longum ICIS-505 Under In Vitro Conditions
Пробиотические свойства композиции индигенных штаммов Bifidobacterium bifidum ICIS-310 и Bifidobacterium longum ICIS-505 в условиях in vitro
· CyberLeninK (CyberLeninka)
Efficacy of Probiotics in the Treatment of Patients with Irritable Bowel Syndrome: Focus on Bifidobacterium longum 35624
Эффективность пробиотиков в лечении пациентов с синдромом раздраженного кишечника: фокус на Bifidobacterium longum 35624
· CyberLeninK (CyberLeninka)
Bifidobacterium longum Y59 modulates the peroxisome proliferator-activated receptor signaling pathway through gut microbiota alterations to ameliorate hyperlipidemia
· Food Bioscience
Alleviating effect of Bifidobacterium longum BL300 on β-lactoglobulin-induced food allergy in young mice
· Acta Alimentaria
Human milk-derived Bifidobacterium longum subsp. infantis CCFM1269 alleviates food allergy by modulating gut microbiota and restoring intestinal barrier
· Scientific Reports
The Combination of Anxiety and Depressive Disorders in Patients with Irritable Bowel Syndrome (Literature Review and Expert Council Resolution)
· Russian Journal of Gastroenterology Hepatology Coloproctology
Multi-component functionalized Bifidobacterium longum hydrogel for multi-target integrated therapy of colitis-associated anxiety and depression
· bioRxiv (Cold Spring Harbor Laboratory)
Desensitizing effects of fermented soymilk with Bifidobacterium longum BL21 and Bifidobacterium lactis BLa80 on a BALB/c mice model of soybean allergy
· Applied Food Research
Preclinical Evaluation of a Ratio-Optimized BALIMONT Multi-Strain Synbiotic Platform for Intestinal Flora Regulation
· International Journal of Public Health and Medical Research
Lycium barbarum polysaccharides and/or Bifidobacterium longum exert anti-inflammation and modulate gut microbiota in rats with dextran sulfate sodium-induced ulcerative colitis
· International Journal of Biological Macromolecules
Combined Effect of Bifidobacterium longum Postbiotics and Dietary Herbs on Ameliorating Metabolic Disturbances in Hyperlipidemic Mice
· Foods
Metabolic pathway analysis reveals hierarchical pentose sugar utilization and metabolic flexibility of Bifidobacterium longum
· Gut Microbes
Neurocognitive effects of postbiotics from Lactobacillus and Bifidobacterium strains in a mouse model of chronic variable stress
· Scientific Reports
Modulating effects of chlorogenic acid and arabinoxylan on gut microbiota and Bifidobacterium longum
· CyTA - Journal of Food
A 90-day oral toxicity study of heat-treated Bifidobacterium longum CECT 7347 (ES1 HT) Postbiotic in rats
· Food and Chemical Toxicology
Prophages of infant-derived Bifidobacterium longum subspecies employ antagonistic and synergistic strategies to persist in their host
· bioRxiv (Cold Spring Harbor Laboratory)
Bifidobacterium longum subsp. infantis B8762 modulates the infant gut-lung axis via microbial and metabolic reprogramming
· Microbial Pathogenesis
Isolation and Characterization of Bifidobacterium longum A1, an Isolate from Faeces of an Exclusively Breast-fed Infant with Probiotic Potential
· Probiotics and Antimicrobial Proteins
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Citations
Selected papers that name this strain.
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[1]
Source →The impact of probiotics on gut health and immune system modulation: A comprehensive study· Journal of Advances in Microbiology Research · 2026
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[2]
PMID 41799757 →Effect of Bifidobacterium longum on cognition and microbiota in post-stroke patients: a single-blinded, controlled trial· International Journal of Medical Sciences · 2026
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[3]
PMID 42047238 →Effects of Live and Heat‐Treated Bifidobacterium longum CECT 7347 in Adults With Allergic Rhinitis: A Randomised, Double‐Blind, Placebo‐Controlled Trial· Allergy · 2026
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[4]
PMID 41523285 →Probiotic Supplementation With Bifidobacterium longum Subsp. Longum BL21 Improves Glycemic Control and Modulates Gut Microbiota in Type 2 Diabetes: A Randomized Controlled Trial· Food Science & Nutrition · 2026
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[5]
PMID 41682832 →Strain-Specific Systematic Review with Meta-Analysis of Probiotics Efficacy in the Treatment of Irritable Bowel Syndrome· Journal of Clinical Medicine · 2026
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[6]
Source →Adjunctive Bifidobacterium longum SX-1326 improves the therapeutic efficacy of Acupotomy in post-stroke dysphagia: A randomized, double-blind, placebo-controlled study· Journal of Functional Foods · 2026
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[7]
Source →Targeting the “gut-immune axis”: Bifidobacterium longum subsp. infantis CCFM111 serves as a novel therapeutic for pediatric allergic rhinitis· Food Science and Human Wellness · 2026
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[8]
PMID 39940249 →Bifidobacterium infantis and Bifidobacterium breve Improve Symptomatology and Neuronal Damage in Neurodegenerative Disease: A Systematic Review· Nutrients · 2025
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[9]
PMID 40817120 →Strain specific effects of probiotic supplementation on serum amino acid profiles in Alzheimer’s disease: a randomized, double blind, placebo controlled trial· Scientific Reports · 2025
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[10]
PMID 40442154 →Integrated multi-omics reveals different host crosstalk of atopic dermatitis-enriched Bifidobacterium longum Strains· npj Biofilms and Microbiomes · 2025