Strain Profile
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Bifidobacterium infantis EVC001
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Human-origin
Where this strain was first isolated, curated from the literature and culture-collection catalogs. It describes provenance only — not suitability, and not benefit.
How we classify this →
Sequenced
Whether a public genome assembly is linked for this strain. Without one the genome screens cannot run. It is not a verdict on the organism.
How we classify this →
Public genome assembly available
Bifidobacterium longum subsp. infantis EVC001 has been studied primarily in neonatal and infant populations, where it is of particular research interest due to its genomic capacity to metabolize human milk oligosaccharides (complex sugars abundant in breast milk). Phase I clinical trial data and multiple observational studies have examined gut colonization following early supplementation in breastfed infants. Observational data from neonatal intensive care settings have examined EVC001 administration in relation to markers of intestinal inflammation and, in some cohorts, in relation to necrotizing enterocolitis, a serious preterm complication, though these come from non-randomized studies. Strain-specific research in adult populations is limited. These are research topics, not findings; the papers do not establish that this strain treats or prevents any condition.
Where it's been studied Tags come from a conservative keyword scan of each paper's title, abstract, and summary. A tag is research coverage, not measured effect. How we classify this →
Share of this strain's 31 body-system-tagged papers that concern each system. Research coverage, not measured effect.
Symptoms in the research A tag means the paper's text names the symptom or condition — research coverage, not evidence of benefit. How we classify this →
Share of this strain's 4 symptom-tagged papers that mention each symptom or condition. Research coverage, not evidence of benefit.
Research Study-type filters use AI-classified labels, audited but not guaranteed — check the paper itself before leaning on one. How we classify this →
36 papers reference this strain in the probiotic database.
Match confidence
How strongly this paper was matched to this strain when the corpus was linked. It orders the list — it says nothing about the study's quality or its findings.
How we classify this →
2025
RCT
2024
OBSERVATIONAL
2022
OBSERVATIONAL
2021
REVIEW
2021
OBSERVATIONAL
2021
OBSERVATIONAL
2021
OBSERVATIONAL
2021
OBSERVATIONAL
2021
OBSERVATIONAL
2020
IN_VITRO
2020
OBSERVATIONAL
2020
OBSERVATIONAL
2020
WGS
2020
OBSERVATIONAL
2020
RCT
2019
WGS
2019
RCT
2019
OBSERVATIONAL
2019
OBSERVATIONAL
2019
IN_VITRO
Browse all 36 papers →
Randomized, placebo-controlled trial reveals the impact of dose and timing of Bifidobacterium infantis probiotic supplementation on breastfed infants’ gut microbiome
· mSphere
Bifidobacterium longum subsp infantis (EVC001) is associated with reduced incidence of necrotizing enterocolitis stage ≥2 and bloody stools in premature babies
· Journal of Perinatology
B. infantis EVC001 Is Well-Tolerated and Improves Human Milk Oligosaccharide Utilization in Preterm Infants in the Neonatal Intensive Care Unit
· Frontiers in Pediatrics
Bifidobacteria-mediated immune system imprinting early in life
· Cell
Impact of Probiotic B. infantis EVC001 Feeding in Premature Infants on the Gut Microbiome, Nosocomially Acquired Antibiotic Resistance, and Enteric Inflammation
· Frontiers in Pediatrics
Early probiotic supplementation with B. infantis in breastfed infants leads to persistent colonization at 1 year
· Pediatric Research
B. infantis EVC001 Colonization in Breastfed Infants Modulates Cytokine Profile Linked to Autoimmune and Allergic Diseases
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Preterm infants fed B. infantis EVC001 Demonstrate Significant Reduction in Intestinal Inflammation via Modulation of Gut Microbiome Composition
· PEDIATRICS
Feeding Activated Bifidobacterium infantis EVC001 to Very Low Birth Weight Infants is Associated with Significant Reduction in Rates of Necrotizing Enterocolitis
· medRxiv
B. Infantis EVC001 Metabolites Improve Enterocyte Proliferation in Vitro
· Current Developments in Nutrition
Impact of Probiotic B. Infantis EVC001 Feeding in Premature Infants on the Gut Microbiome, Nosocomially Acquired Antibiotic Resistance, and Enteric Inflammation
· Research Square
A Microbiome-Based Solution to Address Alarming Levels of Drug-Resistant Bacteria in the Newborn Infant Gut
· Infection Control and Hospital Epidemiology
Key genes involved in utilization of highly abundant HMO in breastmilk are present in B. infantis EVC001 allowing for superior colonization of the breastfed infant gut compared to other commercial probiotic strains
· PEDIATRICS
Colonization Resistance in the Infant Gut: The Role of B. infantis in Reducing pH and Preventing Pathogen Growth
· High-Throughput
Impact of prebiotic (Lacto-N-neotetraose) and probiotic (B. infantis EVC001) supplementation on gut inflammation and fecal pH in young infants suffering from severe acute malnutrition: findings from a randomized controlled trial
· Research Square
Metagenomic analysis reveals reduction in antibiotic resistance genes in breastfed infants fed Bifidobacterium longum subsp. infantis EVC001
· PEDIATRICS
Restoring Bifidobacterium Infantis EVC001 to the Infant Gut Microbiome Significantly Reduces Intestinal Inflammation (OR12-01-19)
· Current Developments in Nutrition
Colonization by B. infantis EVC001 modulates enteric inflammation in exclusively breastfed infants
· Pediatric Research
Early-life gut microbiome modulation reduces the abundance of antibiotic-resistant bacteria
· Antimicrobial Resistance and Infection Control
N-glycans from human milk glycoproteins are selectively released by an infant gut symbiont in vivo
· Journal of Functional Foods
Discussion
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Citations
Selected papers that name this strain.
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[1]
PMID 41427732 →Randomized, placebo-controlled trial reveals the impact of dose and timing of Bifidobacterium infantis probiotic supplementation on breastfed infants’ gut microbiome· mSphere · 2025
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[2]
PMID 34143954 →Bifidobacteria-mediated immune system imprinting early in life· Cell · 2021
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[3]
Source →Feeding Activated Bifidobacterium infantis EVC001 to Very Low Birth Weight Infants is Associated with Significant Reduction in Rates of Necrotizing Enterocolitis· medRxiv · 2021
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[4]
PMID 33762689 →Early probiotic supplementation with B. infantis in breastfed infants leads to persistent colonization at 1 year· Pediatric Research · 2021
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[5]
PMID 33665175 →Impact of Probiotic B. infantis EVC001 Feeding in Premature Infants on the Gut Microbiome, Nosocomially Acquired Antibiotic Resistance, and Enteric Inflammation· Frontiers in Pediatrics · 2021
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[6]
PMID 31443102 →Colonization by B. infantis EVC001 modulates enteric inflammation in exclusively breastfed infants· Pediatric Research · 2019
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[7]
Source →Restoring Bifidobacterium Infantis EVC001 to the Infant Gut Microbiome Significantly Reduces Intestinal Inflammation (OR12-01-19)· Current Developments in Nutrition · 2019
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[8]
PMID 30338216 →Reduced colonic mucin degradation in breastfed infants colonized by Bifidobacterium longum subsp. infantis EVC001· FEBS Open Bio · 2018
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[9]
PMID 29242832 →Persistence of Supplemented Bifidobacterium longum subsp. infantis EVC001 in Breastfed Infants· mSphere · 2017