Strain Profile · NCBI Strain Taxon 637912
Save

Escherichia coli OP50

DEP OP50
◔ Human-origin
Sequenced
Public genome assembly available

Escherichia coli OP50 is a standard laboratory strain widely used as a food source for the model organism Caenorhabditis elegans (a small nematode worm) in aging, metabolism, and host-pathogen research. The research associated with this strain concerns experimental biology — how the bacterium's metabolic activity influences C. elegans lifespan, feeding behavior, and stress responses — rather than any probiotic or health benefit in humans or animals. OP50 is not a probiotic strain and should be understood strictly as a research tool within nematode biology.

Where it's been studied

Share of this strain's 12 body-system-tagged papers that concern each system. Research coverage, not measured effect.

Research

79 papers reference this strain in the probiotic database.

Match confidence
2026 ANIMAL
Bacterial pyruvate metabolism regulates host insulin sensitivity in C. elegans
· bioRxiv (Cold Spring Harbor Laboratory)
2025 ANIMAL
Impact of bacterial inactivation methods on Caenorhabditis elegans feeding and healthspan
· Scientific Reports
2023 ANIMAL
Difference in Intestine Content of Caenorhabditis elegans When Fed on Non-Pathogenic or Pathogenic Bacteria
· Micromachines
2020 IN_VITRO
Bacterially produced metabolites protect C. elegans neurons from degeneration
· PLoS Biology
2015 IN_VITRO
Bacterial Respiration and Growth Rates Affect the Feeding Preferences, Brood Size and Lifespan of Caenorhabditis elegans
· PLoS ONE
2014 ANIMAL
Bdellovibrio bacteriovorus protects Caenorhabditis elegans from bacterial pathogens
· Fine Focus
2026 ANIMAL
Salmonella Typhimurium Vitamin B12-dependent Methionine metabolism regulates C. elegans Development
· bioRxiv (Cold Spring Harbor Laboratory)
2021 ANIMAL
Author response: NHR-49/PPAR-α and HLH-30/TFEB cooperate for C. elegans host defense via a flavin-containing monooxygenase
·
2020 ANIMAL
Decision letter: NHR-49/PPAR-α and HLH-30/TFEB cooperate for C. elegans host defense via a flavin-containing monooxygenase
·
2019 IN_VITRO
Using Bacterial Transcriptomics to Investigate Targets of Host-Bacterial Interactions in Caenorhabditis elegans
· Scientific Reports
2019 ANIMAL
Interplay between mitochondria and diet mediates pathogen and stress resistance in Caenorhabditis elegans
· PLoS Genetics
2018 ANIMAL
El papel de la microbiota en el tratamiento contra el cáncer
· Biosaia: Revista de los másteres de Biotecnología Sanitaria y Biotecnología Ambiental, Industrial y Alimentaria
2017 ANIMAL
Probing the bacterial pathogenesis of ESKAPE species utilising C. elegans as a model system
· ePrints Soton (University of Southampton)
2003 ANIMAL
Virulenzanalyse unterschiedlicher Morphotypen von Pseudomonas aeruginosa und Spezies der Gattung Burkholderia
·
2026 ANIMAL
Pathogenicity and intestinal barrier disruptive ability of Malassezia furfur in an alternative model host Caenorhabditis elegans is partially alleviated by Lacticaseibacillus rhamnosus
· FEMS Microbes
2026 ANIMAL
Effects and mechanisms of lifespan extension and healthspan promotion induced by Limosilactobacillus reuteri (Lactobacillus reuteri) A21041
· Frontiers in Nutrition
2026 ANIMAL
Natural commensal microbes induce internal hatching in C. elegans
· Microbiology Spectrum
2026 ANIMAL
Supplementary file 1_Effects and mechanisms of lifespan extension and healthspan promotion induced by Limosilactobacillus reuteri (Lactobacillus reuteri) A21041.pdf
· Figshare
2026 ANIMAL
Lactiplantibacillus plantarum Q7 relieves senescence by improving intestinal homeostasis in Caenorhabditis elegans
· Food Quality and Safety
2026 ANIMAL
Peptone-Free Nematode Growth Medium Improves Culture Stability and Physiological Resilience in Caenorhabditis elegans
· Preprints.org
Browse all 79 papers →

Discussion

Be the first to comment.

Sign in to join the discussion.

No comments yet.