Lactobacillus plantarum DP189
Lactiplantibacillus plantarum DP189 (formerly Lactobacillus plantarum DP189) has been investigated in animal models for neuroprotective and cognitive properties via the gut-microbiota-brain axis — the proposed bidirectional communication pathway between the gut and central nervous system. Two 2021-2022 mouse studies using Parkinson's disease and Alzheimer's disease models examined oxidative stress markers, gut microbiota composition, and neuroinflammatory signaling pathways. A 2024 animal study also examined the strain in the context of polyethylene microplastic-induced neurotoxicity and the microbiota-gut-brain axis. All findings are in animal models; no human clinical trials were identified, and the translational significance of these results for humans is not yet established. These are research topics, not findings; the papers do not establish that this strain treats or prevents any condition.
Where it's been studied Tags come from a conservative keyword scan of each paper's title, abstract, and summary. A tag is research coverage, not measured effect. How we classify this →
Share of this strain's 5 body-system-tagged papers that concern each system. Research coverage, not measured effect.
Symptoms in the research A tag means the paper's text names the symptom or condition — research coverage, not evidence of benefit. How we classify this →
Share of this strain's 1 symptom-tagged papers that mention each symptom or condition. Research coverage, not evidence of benefit.
Research Study-type filters use AI-classified labels, audited but not guaranteed — check the paper itself before leaning on one. How we classify this →
5 papers reference this strain in the probiotic database.
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Citations
Selected papers that name this strain.
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[1]
PMID 38484610 →Oxidized/unmodified-polyethylene microplastics neurotoxicity in mice: Perspective from microbiota-gut-brain axis· Environment International · 2024
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[2]
PMID 35067061 →Lactobacillus plantarum DP189 Reduces α-SYN Aggravation in MPTP-Induced Parkinson’s Disease Mice via Regulating Oxidative Damage, Inflammation, and Gut Microbiota Disorder· Journal of Agricultural and Food Chemistry · 2022
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[3]
Source →Neuroprotective effect of Lactobacillus plantarum DP189 on MPTP-induced Parkinson's disease model mice· Journal of Functional Foods · 2021
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[4]
PMID 34755592 →Lactobacillus plantarum DP189 prevents cognitive dysfunction in D-galactose/AlCl3 induced mouse model of Alzheimer’s disease via modulating gut microbiota and PI3K/Akt/GSK-3β signaling pathway· Nutritional Neuroscience · 2021