Strain Profile
· NCBI Strain Taxon
362948
NCBI Taxonomy's node for this specific strain. A different identifier from the culture-collection deposit numbers below, which name a physical stock rather than a taxonomic node.
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Ligilactobacillus salivarius UCC118
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Human-origin
Where this strain was first isolated, curated from the literature and culture-collection catalogs. It describes provenance only — not suitability, and not benefit.
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Sequenced
Whether a public genome assembly is linked for this strain. Without one the genome screens cannot run. It is not a verdict on the organism.
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Public genome assembly available
Ligilactobacillus salivarius UCC118 is a well-studied gastrointestinal strain notable for its production of Abp118, a broad-spectrum bacteriocin (a ribosomally synthesized antimicrobial peptide), which has been studied in the context of competitive exclusion of pathogens in the gut. Animal studies using DSS-induced colitis models have examined this strain in the context of intestinal inflammation and microbiota composition. An observational study in healthy human athletes examined UCC118 supplementation in relation to exercise-induced intestinal permeability changes (commonly called 'leaky gut'), though this was a small, non-randomized investigation. In vitro research has documented how the strain interacts with epithelial cells and macrophages. These are research topics, not findings; the papers do not establish that this strain treats or prevents any condition.
Where it's been studied Tags come from a conservative keyword scan of each paper's title, abstract, and summary. A tag is research coverage, not measured effect. How we classify this →
Share of this strain's 44 body-system-tagged papers that concern each system. Research coverage, not measured effect.
Symptoms in the research A tag means the paper's text names the symptom or condition — research coverage, not evidence of benefit. How we classify this →
Share of this strain's 12 symptom-tagged papers that mention each symptom or condition. Research coverage, not evidence of benefit.
Research Study-type filters use AI-classified labels, audited but not guaranteed — check the paper itself before leaning on one. How we classify this →
60 papers reference this strain in the probiotic database.
Match confidence
How strongly this paper was matched to this strain when the corpus was linked. It orders the list — it says nothing about the study's quality or its findings.
How we classify this →
2022
ANIMAL
2021
IN_VITRO
2019
OBSERVATIONAL
2019
OBSERVATIONAL
2018
OBSERVATIONAL
2016
ANIMAL
2014
RCT
2014
ANIMAL
2012
RCT
2012
IN_VITRO
2012
IN_VITRO
2012
ANIMAL
2012
ANIMAL
2012
ANIMAL
2011
WGS
2010
REVIEW
2009
IN_VITRO
2009
IN_VITRO
2009
WGS
2007
ANIMAL
Browse all 60 papers →
Lactobacillus salivarius UCC118™ Dampens Inflammation and Promotes Microbiota Recovery to Provide Therapeutic Benefit in a DSS-Induced Colitis Model
· Microorganisms
Macrophage cytokine responses to commensal Gram-positive Lactobacillus salivarius strains are TLR2-independent and Myd88-dependent
· Scientific Reports
(untitled)
· Physiological Reports
UCC118 supplementation reduces exercise‐induced gastrointestinal permeability and remodels the gut microbiome in healthy humans
· Physiological Reports
Effects Of A Novel Probiotic On Exercise-Induced Gut Permeability and Microbiota in Endurance Athletes
· Medicine & Science in Sports & Exercise
Lactobacillus salivarius Isolated from Patients with Rheumatoid Arthritis Suppresses Collagen-Induced Arthritis and Increases Treg Frequency in Mice
· Journal of Interferon & Cytokine Research
PPO.19 Probiotics in obese pregnancy to reduce maternal fasting glucose: A randomised controlled trial
· Archives of Disease in Childhood Fetal & Neonatal
Converging effects of a Bifidobacterium and Lactobacillus probiotic strain on mouse intestinal physiology
· American Journal of Physiology-Gastrointestinal and Liver Physiology
A one year, randomised, double blind, placebo controlled trial of probiotics. Bifidobacterium infantis 35624 or Lactobacillus salivarious UCC118, as food supplements for maintenance of remission in Ulcerative colitis.
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Influence of Adhesion and Bacteriocin Production by Lactobacillus salivarius on the Intestinal Epithelial Cell Transcriptional Response
· Applied and Environmental Microbiology
Mechanism of protection of transepithelial barrier function by Lactobacillus salivarius: strain dependence and attenuation by bacteriocin production
· American Journal of Physiology-Gastrointestinal and Liver Physiology
Divergent metabolic outcomes arising from targeted manipulation of the gut microbiota in diet-induced obesity
· Gut
Effect of Lactobacillus salivarius Bacteriocin Abp118 on the Mouse and Pig Intestinal Microbiota
· PLoS ONE
L. plantarum, L. salivarius, and L. lactis Attenuate Th2 Responses and Increase Treg Frequencies in Healthy Mice in a Strain Dependent Manner
· PLoS ONE
Production of Multiple Bacteriocins from a Single Locus by Gastrointestinal Strains of Lactobacillus salivarius
· Journal of Bacteriology
Probiotic Properties of Lactobacillus Salivarius and Closely Related Lactobacillus Species
· Future Microbiology
Lactobacillus salivarius modulates cytokine induction and virulence factor gene expression in Helicobacter pylori
· Journal of Medical Microbiology
AI-2 signalling is induced by acidic shock in probiotic strains of Lactobacillus spp.
· International Journal of Food Microbiology
Allelic Variation of Bile Salt Hydrolase Genes in Lactobacillus salivarius Does Not Determine Bile Resistance Levels
· Journal of Bacteriology
Bacteriocin production as a mechanism for the antiinfective activity of Lactobacillus salivarius UCC118
· Proceedings of the National Academy of Sciences
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Citations
Selected papers that name this strain.
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[1]
PMID 35889102 →Lactobacillus salivarius UCC118™ Dampens Inflammation and Promotes Microbiota Recovery to Provide Therapeutic Benefit in a DSS-Induced Colitis Model· Microorganisms · 2022
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[2]
PMID 31758610 →UCC118 supplementation reduces exercise‐induced gastrointestinal permeability and remodels the gut microbiome in healthy humans· Physiological Reports · 2019
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[3]
Source →A one year, randomised, double blind, placebo controlled trial of probiotics. Bifidobacterium infantis 35624 or Lactobacillus salivarious UCC118, as food supplements for maintenance of remission in Ulcerative colitis.· · 2012
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[4]
Source →A Randomised Controlled Trial of a Probiotic Lactobacillus Strain in Healthy Adults: Assessment of its Delivery, Transit and Influence on Microbial Flora and Enteric Immunity· Microbial Ecology in Health and Disease · 2002
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[5]
Source →A Randomised Controlled Trial of a Probiotic Lactobacillus Strain in Healthy Adults: Assessment of its Delivery, Transit and Influence on Microbial Flora and Enteric Immunity· Microbial Ecology in Health and Disease · 2002