Strain Profile
· NCBI Strain Taxon
880592
NCBI Taxonomy's node for this specific strain. A different identifier from the culture-collection deposit numbers below, which name a physical stock rather than a taxonomic node.
How we classify this →
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Lacticaseibacillus rhamnosus R0011
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Food-origin
Where this strain was first isolated, curated from the literature and culture-collection catalogs. It describes provenance only — not suitability, and not benefit.
How we classify this →
Sequenced
Whether a public genome assembly is linked for this strain. Without one the genome screens cannot run. It is not a verdict on the organism.
How we classify this →
Public genome assembly available
Lacticaseibacillus rhamnosus R0011 is a well-studied probiotic strain with a research base spanning food technology, immunology, and gut health. In vitro studies have examined cytokine profiles in macrophage models in the context of immune regulation, and it has been investigated in combination with other lactobacilli in two randomized controlled trials — one in the context of adjunctive use in chronic rhinosinusitis and one in the context of antibiotic-associated diarrhea in healthy adults. Animal research has also explored interactions with gut microbiota composition. These are research topics, not findings; the papers do not establish that this strain treats or prevents any condition.
Where it's been studied Tags come from a conservative keyword scan of each paper's title, abstract, and summary. A tag is research coverage, not measured effect. How we classify this →
Share of this strain's 73 body-system-tagged papers that concern each system. Research coverage, not measured effect.
+3 more systems
Symptoms in the research A tag means the paper's text names the symptom or condition — research coverage, not evidence of benefit. How we classify this →
Share of this strain's 30 symptom-tagged papers that mention each symptom or condition. Research coverage, not evidence of benefit.
Research Study-type filters use AI-classified labels, audited but not guaranteed — check the paper itself before leaning on one. How we classify this →
86 papers reference this strain in the probiotic database.
Match confidence
How strongly this paper was matched to this strain when the corpus was linked. It orders the list — it says nothing about the study's quality or its findings.
How we classify this →
2025
ANIMAL
2025
OTHER
2025
IN_VITRO
2024
IN_VITRO
2023
RCT
2022
ANIMAL
2022
IN_VITRO
2022
ANIMAL
2022
IN_VITRO
2022
IN_VITRO
2022
ANIMAL
2022
RCT
2021
RCT
2021
ANIMAL
2021
IN_VITRO
2020
IN_VITRO
2020
IN_VITRO
2020
IN_VITRO
2020
IN_VITRO
2020
IN_VITRO
Browse all 86 papers →
The Effect of Gut Microbiome Perturbation on the Bioavailability of Glycyrrhizic Acid in Rats
· Pharmaceutics
Metabolomic Signatures of Probiotic Secretomes Reveal Strain-Specific Biofunctional Potential: Insights from Lacticaseibacillus rhamnosus R0011 and Bifidobacterium longum R0175
· Borealis
Probiotic secretomes and prebiotics modulate the adverse effects of polychlorinated biphenyls on in vitro intestinal outcomes
· Open MIND
A Lacticaseibacillus rhamnosus secretome induces immunoregulatory transcriptional, functional and immunometabolic signatures in human THP-1 monocytes
· Scientific Reports
Efficacy and safety of Lacticaseibacillus rhamnosus R0011 and Lactobacillus helveticus R0052 as an adjuvant for Helicobacter pylori eradication: a double-blind, randomized, placebo-controlled study
· Frontiers in Gastroenterology
Maternal Administration Of Probiotic Lactobacilli Since Pre-Conception Programs Offspring Gut Microbiota Functions
· Current Developments in Nutrition
Lacticaseibacillus rhamnosus R0011 secretome attenuates Salmonella enterica serovar Typhimurium secretome-induced intestinal epithelial cell monolayer damage and pro-inflammatory mediator production in intestinal epithelial cell and antigen-presenting cell co-cultures
· Frontiers in Microbiology
The Bioavailability of Glycyrrhizinic Acid Was Enhanced by Probiotic Lactobacillus rhamnosus R0011 Supplementation in Liver Fibrosis Rats
· Nutrients
Strategies to improve the survival of probiotic Lacticaseibacillus rhamnosus R0011 during the production and storage of granola bars
· Canadian Journal of Microbiology
Probiotics Exhibit Strain-Specific Protective Effects in T84 Cells Challenged With Clostridioides difficile-Infected Fecal Water
· Frontiers in Microbiology
The effects of antimicrobials and lipopolysaccharide on acute immune responsivity in pubertal male and female CD1 mice
· Comprehensive Psychoneuroendocrinology
Beneficial Shifts in Gut Microbiota by Lacticaseibacillus rhamnosus R0011 and Lactobacillus helveticus R0052 in Alcoholic Hepatitis
· Microorganisms
Pathogen-Specific Effects of Probiotics in Children With Acute Gastroenteritis Seeking Emergency Care: A Randomized Trial
· Clinical Infectious Diseases
Lactobacillus rhamnosus R0011 Treatment Enhanced Efficacy of Capecitabine against Colon Cancer in Male Balb/c Mice
· Nutrition and Cancer
Probiotic protection against dysregulated gut microbiota and intestinal cell functionality induced by «Clostridioides difficile»
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Temporal transcriptional, metabolic, and functional re-programming of THP-1 macrophages by the Lactobacillus rhamnosus R0011 secretome
· The Journal of Immunology
Milk fermented with Lactobacillus rhamnosus R0011 induces a regulatory cytokine profile in LPS-challenged U937 and THP-1 macrophages
· Current Research in Food Science
Characterization of casein-derived peptide bioactivity: Differential effects on angiotensin-converting enzyme inhibition and cytokine and nitric oxide production
· Journal of Dairy Science
Fermentation of Wheat Bran and Whey Permeate by Mono-Cultures of Lacticaseibacillus rhamnosus Strains and Co-culture With Yeast Enhances Bioactive Properties
· Frontiers in Bioengineering and Biotechnology
Secretome-Mediated Interactions with Intestinal Epithelial Cells: A Role for Secretome Components from Lactobacillus rhamnosus R0011 in the Attenuation of Salmonella enterica Serovar Typhimurium Secretome and TNF-α–Induced Proinflammatory Responses
· The Journal of Immunology
Discussion
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Citations
Selected papers that name this strain.
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[1]
Source →Probiotic secretomes and prebiotics modulate the adverse effects of polychlorinated biphenyls on in vitro intestinal outcomes· Open MIND · 2025
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[2]
PMID 41821821 →Efficacy and safety of Lacticaseibacillus rhamnosus R0011 and Lactobacillus helveticus R0052 as an adjuvant for Helicobacter pylori eradication: a double-blind, randomized, placebo-controlled study· Frontiers in Gastroenterology · 2023
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[3]
PMID 35154018 →Probiotics Exhibit Strain-Specific Protective Effects in T84 Cells Challenged With Clostridioides difficile-Infected Fecal Water· Frontiers in Microbiology · 2022
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[4]
PMID 36246229 →Lacticaseibacillus rhamnosus R0011 secretome attenuates Salmonella enterica serovar Typhimurium secretome-induced intestinal epithelial cell monolayer damage and pro-inflammatory mediator production in intestinal epithelial cell and antigen-presenting cell co-cultures· Frontiers in Microbiology · 2022
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[5]
PMID 35889193 →Beneficial Shifts in Gut Microbiota by Lacticaseibacillus rhamnosus R0011 and Lactobacillus helveticus R0052 in Alcoholic Hepatitis· Microorganisms · 2022
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[6]
PMID 32238458 →Secretome-Mediated Interactions with Intestinal Epithelial Cells: A Role for Secretome Components from Lactobacillus rhamnosus R0011 in the Attenuation of Salmonella enterica Serovar Typhimurium Secretome and TNF-α–Induced Proinflammatory Responses· The Journal of Immunology · 2020
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[7]
PMID 30524427 →Suppression of Intestinal Epithelial Cell Chemokine Production by Lactobacillus rhamnosus R0011 and Lactobacillus helveticus R0389 Is Mediated by Secreted Bioactive Molecules· Frontiers in Immunology · 2018
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[8]
Source →Probiotic Lacidofil® STRONG Mitigates the Antibiotic‐Induced Alteration of the Fecal microRNA Signature in Healthy Humans· The FASEB Journal · 2016
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[9]
Source →Experience using probiotic strains Lactobacillus acidophilus R0052 and Lactobacillus rhamnosus R0011 in children with burn injuriesДосвід використання пробіотичних штамів Lactobacillus acidophilus R0052 та Lactobacillus rhamnosus R0011 у дітей з опіковою травмою· GASTROENTEROLOGY · 2016
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[10]
PMID 25692549 →Probiotics (Lactobacillus rhamnosus R0011 and acidophilus R0052) Reduce the Expression of Toll-Like Receptor 4 in Mice with Alcoholic Liver Disease· PLoS ONE · 2015