Strain Profile
· NCBI Strain Taxon
1074494
NCBI Taxonomy's node for this specific strain. A different identifier from the culture-collection deposit numbers below, which name a physical stock rather than a taxonomic node.
How we classify this →
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Streptococcus salivarius M18
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Human-origin
Where this strain was first isolated, curated from the literature and culture-collection catalogs. It describes provenance only — not suitability, and not benefit.
How we classify this →
Sequenced
Whether a public genome assembly is linked for this strain. Without one the genome screens cannot run. It is not a verdict on the organism.
How we classify this →
Public genome assembly available
Streptococcus salivarius M18 is an oral probiotic strain with a growing body of randomized controlled trial evidence focused on dental and periodontal health. Multiple RCTs have examined M18 supplementation in relation to salivary Streptococcus mutans counts, plaque accumulation, and gingival bleeding, including a three-month double-blind trial. Additional trials in orthodontic patients have examined biofilm formation and halitosis, in connection with the strain's documented production of salivaricin (a bacteriocin active against certain oral pathogens) and its persistence in the oral cavity. Observational work has also examined plasma nitrite levels and blood pressure in connection with M18 supplementation. These are research topics, not findings; the papers do not establish that this strain treats or prevents any condition.
Where it's been studied Tags come from a conservative keyword scan of each paper's title, abstract, and summary. A tag is research coverage, not measured effect. How we classify this →
Share of this strain's 39 body-system-tagged papers that concern each system. Research coverage, not measured effect.
Symptoms in the research A tag means the paper's text names the symptom or condition — research coverage, not evidence of benefit. How we classify this →
Share of this strain's 38 symptom-tagged papers that mention each symptom or condition. Research coverage, not evidence of benefit.
Research Study-type filters use AI-classified labels, audited but not guaranteed — check the paper itself before leaning on one. How we classify this →
42 papers reference this strain in the probiotic database.
Match confidence
How strongly this paper was matched to this strain when the corpus was linked. It orders the list — it says nothing about the study's quality or its findings.
How we classify this →
2026
OBSERVATIONAL
2025
RCT
2025
RCT
2025
OBSERVATIONAL
2024
RCT
2024
OBSERVATIONAL
2024
RCT
2024
IN_VITRO
2024
RCT
2024
OBSERVATIONAL
2024
IN_VITRO
2024
REVIEW
2023
RCT
2023
IN_VITRO
2023
RCT
2023
RCT
2022
OTHER
2022
IN_VITRO
2022
OBSERVATIONAL
2021
IN_VITRO
Browse all 42 papers →
Effectiveness of Streptococcus salivarius probiotics on alleviating radiation-induced oral mucositis via inflammatory and microecological modulation: a prospective pragmatic interventional study in nasopharyngeal carcinoma
· Frontiers in Immunology
A New Frontier in Oral Care: Live Streptococcus salivarius M18 Probiotic Toothpaste
· Applied Microbiology
Adjunctive use of Streptococcus salivarius M18 probiotic in the treatment of periodontitis: a randomized controlled trial
· 3 Biotech
Clinical and laboratory assessment of the effectiveness of a probiotic S. salivarius M18 complex inclusion as a prevention of children’s dental diseases with impaired phosphorus-calcium metabolism
· Clinical Dentistry (Russia)
Evaluation of the effects of Streptococcus salivarius M18 and K12 probiotic bacteria on the Streptococcus mutans in saliva: A randomized clinical trial
· Dental Research Journal
Analysis of Oral and Gut Microbiota Composition in Children with Dental Caries by NGS Approaches
· Recent Advances in Inflammation & Allergy Drug Discovery
A Three-Month Probiotic (the Streptococcus salivarius M18 Strain) Supplementation Decreases Gingival Bleeding and Plaque Accumulation: A Randomized Clinical Trial
· Dentistry Journal
Application of Prebiotics and Probiotics to Improve Oral and Dental Health by Inhibiting Streptococcus mutans
· Jundishapur Journal of Microbiology
Evaluation of the effects of probiotic pills on the oral plaque indices: A randomized clinical trial
· Dental Research Journal
The impact of probiotic supplementation on dental and general health metrics in pediatric populations
· Pediatric dentistry and dental prophylaxis
Antimicrobial effect of probiotic bacteriocins on Streptococcus mutans biofilm in a dynamic oral flow chamber model – an in vitro study
· Journal of Oral Microbiology
Streptococcus salivarius Role as a Probiotic in Children’s Health and Disease Prophylaxis—A Systematic Review
· Life
Randomized Clinical Trial of Oral Probiotic Streptococcus salivarius M18 on Salivary Streptococcus mutans in Preprimary Children
· International Journal of Clinical Pediatric Dentistry
Capsaicin Shows Species and Strain-specific Activity: Investigation of the Antibacterial Effects on the Oral Pathogen Streptococcus mutans and the Oral Probiotics Streptococcus salivarius M18 and K12
· Hacettepe Journal of Biology and Chemistry
Antigingivitis and Antiplaque Effects of Oral Probiotic Containing the Streptococcus salivarius M18 Strain: A Randomized Clinical Trial
· Nutrients
The Probiotic Streptococcus salivarius M18 Increases Plasma Nitrite but Does Not Alter Blood Pressure: A Pilot Randomised Controlled Trial
· Applied Microbiology
Safety assessment of Streptococcus salivarius M18 a probiotic for oral health
· Beneficial Microbes
Lyophilized cell-free supernatants of the oral probiotics Streptococcus salivarius M18 and Streptococcus salivarius K12 show promises for milk safety
· Letters in Applied Microbiology
Changes in the main dental parameters of preschoolers with caries affected by long-term probiotic intake
· Pediatric dentistry and dental prophylaxis
A concerted probiotic activity to inhibit periodontitis-associated bacteria
· PLoS ONE
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Citations
Selected papers that name this strain.
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[1]
PMID 40443548 →Adjunctive use of Streptococcus salivarius M18 probiotic in the treatment of periodontitis: a randomized controlled trial· 3 Biotech · 2025
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[2]
PMID 35098909 →Safety assessment of Streptococcus salivarius M18 a probiotic for oral health· Beneficial Microbes · 2022
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[3]
Source →Changes in the main dental parameters of preschoolers with caries affected by long-term probiotic intake· Pediatric dentistry and dental prophylaxis · 2022
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[4]
PMID 26491371 →Cariogram outcome after 90 days of oral treatment with Streptococcus salivarius M18 in children at high risk for dental caries: results of a randomized, controlled study· Clinical Cosmetic and Investigational Dentistry · 2015
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[5]
PMID 23449874 →Influence of the probiotic Streptococcus salivarius strain M18 on indices of dental health in children: a randomized double-blind, placebo-controlled trial· Journal of Medical Microbiology · 2013