Strain Profile
· NCBI Strain Taxon
1200793
NCBI Taxonomy's node for this specific strain. A different identifier from the culture-collection deposit numbers below, which name a physical stock rather than a taxonomic node.
How we classify this →
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Streptococcus salivarius K12
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Human-origin
Where this strain was first isolated, curated from the literature and culture-collection catalogs. It describes provenance only — not suitability, and not benefit.
How we classify this →
Sequenced
Whether a public genome assembly is linked for this strain. Without one the genome screens cannot run. It is not a verdict on the organism.
How we classify this →
Public genome assembly available
Streptococcus salivarius K12 is an oral probiotic strain with one of the broader clinical evidence bases in upper respiratory and oral health research. Multiple randomized controlled trials have evaluated this strain specifically, with studies examining streptococcal pharyngitis episode frequency in school-age children, oral hygiene parameters, and recurrent ear infections and PFAPA syndrome. Observational studies in pediatric populations add context, and in vitro work has examined its interactions with odor-causing and virulent oral bacteria. Evidence is most concentrated in oral and upper respiratory contexts. These are research topics, not findings; the papers do not establish that this strain treats or prevents any condition.
Where it's been studied Tags come from a conservative keyword scan of each paper's title, abstract, and summary. A tag is research coverage, not measured effect. How we classify this →
Share of this strain's 114 body-system-tagged papers that concern each system. Research coverage, not measured effect.
+3 more systems
Symptoms in the research A tag means the paper's text names the symptom or condition — research coverage, not evidence of benefit. How we classify this →
Share of this strain's 90 symptom-tagged papers that mention each symptom or condition. Research coverage, not evidence of benefit.
+1 more symptoms
Research Study-type filters use AI-classified labels, audited but not guaranteed — check the paper itself before leaning on one. How we classify this →
153 papers reference this strain in the probiotic database.
Match confidence
How strongly this paper was matched to this strain when the corpus was linked. It orders the list — it says nothing about the study's quality or its findings.
How we classify this →
2026
RCT
2026
OBSERVATIONAL
2026
RCT
2026
RCT
2026
RCT
2026
OBSERVATIONAL
2026
RCT
2026
RCT
2025
RCT
2025
RCT
2025
IN_VITRO
2025
OBSERVATIONAL
2025
RCT
2025
RCT
2025
ANIMAL
2025
RCT
2025
RCT
2025
RCT
2024
ANIMAL
2024
RCT
Browse all 153 papers →
Effect of probiotic lozenges on improvement in tympanometric classification within 12 weeks in children aged 3–6 years with adenoid hypertrophy and otitis media with effusion undergoing non-surgical management: a randomized controlled trial
· Frontiers in Cellular and Infection Microbiology
Changes in the oral microbiocenosis during its correction with probiotics
ИЗМЕНЕНИЕ МИКРОБИОЦЕНОЗА ПОЛОСТИ РТА ПРИ КОРРЕКЦИИ ЕГО ПРОБИОТИКАМИ
· Флагман науки
Preventing otitis media and respiratory tract infections with the oral probiotic Streptococcus salivarius K12
· European Journal of Pediatrics
Tongue brushing and oral probiotics for the treatment of halitosis: a randomized controlled trial
· Journal of Breath Research
Clinical and Microbiological Effects of Streptococcus salivarius K12 Lozenges and Zinc Mouthrinse on Persistent Intra-Oral Halitosis
· Microorganisms
Evaluation of the Efficacy of Colchicine and Streptococcus salivarius K12 Therapy in PFAPA Syndrome
· DergiPark (Istanbul University)
ROLE OF PROBIOTICS IN REDUCING RECURRENCE OF ACUTE EXACERBATIONS OF CHRONIC TONSILLITIS IN CHILDREN
· Zenodo (CERN European Organization for Nuclear Research)
The effect of a 3-month oral probiotic (Streptococcus salivarius strain K12) administration on dental health indicators. (A randomized clinical trial)
· Russian Journal of Stomatology
Streptococcus salivarius Probiotics to Prevent Acute Otitis Media in Children: A Randomized Clinical Trial
·
Oral Probiotic Containing Streptococcus salivarius K12 and Lactobacillus brevis CD2 for Preventing Bacterial Pneumonia in Severe COVID-19: Randomized Clinical Trial
· The Journal of Contemporary Dental Practice
Environmental pH controls antimicrobial production by human probiotic Streptococcus salivarius
· Journal of Bacteriology
USE OF THE PROBIOTIC STREPTOCOCCUS SALIVARIUS K12 TO CORRECT THE ORAL MICROBIOME IN CHILDREN WITH OSTEOGENESIS IMPERFECTA
· Intermedical journal
Preventing Oral Health Problems in Children with Autism Spectrum Disorder: A Feasible Mission?
· Pediatric dentistry and dental prophylaxis
Multisystemic effect of probiotics: evaluation of comprehensive treatment of acute tonsillitis in children
· CHILD`S HEALTH
Effect of Probiotic Streptococcus salivarius K12 Application on Palatal Wound Healing: An in Vivo Study
· Malaysian Journal of Medical Sciences
The use of Streptococcus salivarius K12 and Lactobacillus rhamnosus LGG in the treatment of streptococcal tonsillitis in children
· Modern pediatrics Ukraine
Data Sheet 1_Study to evaluate the safety and tolerability of Streptococcus salivarius eK12, a genetically modified strain derived from the oral probiotic S. salivarius K12: Results from a randomized, double-blind, placebo-controlled, parallel-group clinical trial.zip
· Figshare
Use of Streptococcus salivarius K12 and Lactobacillus rhamnosus LGG in the treatment of streptococcal tonsillitis in children
Застосування Streptococcus salivarius K12 і Lactobacillus rhamnosus LGG у лікуванні стрептококового тонзиліту в дітей
· The Scientific Issues of Ternopil Volodymyr Hnatiuk National Pedagogical University Series pedagogy
Acute oral toxicity evaluation of synbiotic mixture containing Streptococcus salivarius K12 and Musa acuminata aqueous peel extract in Sprague-Dawley rats
· Journal of Ayurveda and Integrative Medicine
Streptococcus salivarius K12 Alleviates Oral Mucositis in Patients Undergoing Radiotherapy for Malignant Head and Neck Tumors: A Randomized Controlled Trial
· Journal of Clinical Oncology
Discussion
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Citations
Selected papers that name this strain.
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[1]
Source →Evaluation of the Efficacy of Colchicine and Streptococcus salivarius K12 Therapy in PFAPA Syndrome· DergiPark (Istanbul University) · 2026
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[2]
PMID 42693329 →Preventing otitis media and respiratory tract infections with the oral probiotic Streptococcus salivarius K12· European Journal of Pediatrics · 2026
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[3]
PMID 41604763 →Tongue brushing and oral probiotics for the treatment of halitosis: a randomized controlled trial· Journal of Breath Research · 2026
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[4]
Source →ROLE OF PROBIOTICS IN REDUCING RECURRENCE OF ACUTE EXACERBATIONS OF CHRONIC TONSILLITIS IN CHILDREN· Zenodo (CERN European Organization for Nuclear Research) · 2026
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[5]
Source →The effect of a 3-month oral probiotic (Streptococcus salivarius strain K12) administration on dental health indicators. (A randomized clinical trial)· Russian Journal of Stomatology · 2026
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[6]
PMID 41737842 →Effect of probiotic lozenges on improvement in tympanometric classification within 12 weeks in children aged 3–6 years with adenoid hypertrophy and otitis media with effusion undergoing non-surgical management: a randomized controlled trial· Frontiers in Cellular and Infection Microbiology · 2026
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[7]
Source →Streptococcus salivarius Probiotics to Prevent Acute Otitis Media in Children: A Randomized Clinical Trial· · 2025
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[8]
Source →Data Sheet 1_Study to evaluate the safety and tolerability of Streptococcus salivarius eK12, a genetically modified strain derived from the oral probiotic S. salivarius K12: Results from a randomized, double-blind, placebo-controlled, parallel-group clinical trial.zip· Figshare · 2025
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[9]
PMID 38215354 →Streptococcus salivarius K12 Alleviates Oral Mucositis in Patients Undergoing Radiotherapy for Malignant Head and Neck Tumors: A Randomized Controlled Trial· Journal of Clinical Oncology · 2024
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[10]
PMID 39597553 →Efficacy of Streptococcus salivarius Blis K12 in the Prevention of Upper Respiratory Tract Infections in Physically Active Individuals: A Randomized Controlled Trial· Microorganisms · 2024