Strain Profile
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Bifidobacterium lactis HN019
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Human-origin
Where this strain was first isolated, curated from the literature and culture-collection catalogs. It describes provenance only — not suitability, and not benefit.
How we classify this →
Sequenced
Whether a public genome assembly is linked for this strain. Without one the genome screens cannot run. It is not a verdict on the organism.
How we classify this →
Public genome assembly available
Bifidobacterium animalis subsp. lactis HN019 is among the more extensively studied probiotic strains, with human clinical trials exploring its potential across several areas. Randomized controlled trials have examined it in the context of gut regularity, including a 2024 RCT examining functional constipation symptoms, and preliminary human data have also examined oral health markers such as gingivitis. Animal and in vitro work has examined interactions with the immune system and gut microbiota composition, and the mechanisms and clinical relevance remain under investigation. Human evidence exists but is still building, and no single benefit has been established. These are research topics, not findings; the papers do not establish that this strain treats or prevents any condition.
Where it's been studied Tags come from a conservative keyword scan of each paper's title, abstract, and summary. A tag is research coverage, not measured effect. How we classify this →
Share of this strain's 188 body-system-tagged papers that concern each system. Research coverage, not measured effect.
+4 more systems
Symptoms in the research A tag means the paper's text names the symptom or condition — research coverage, not evidence of benefit. How we classify this →
Share of this strain's 116 symptom-tagged papers that mention each symptom or condition. Research coverage, not evidence of benefit.
Research Study-type filters use AI-classified labels, audited but not guaranteed — check the paper itself before leaning on one. How we classify this →
237 papers reference this strain in the probiotic database.
Match confidence
How strongly this paper was matched to this strain when the corpus was linked. It orders the list — it says nothing about the study's quality or its findings.
How we classify this →
2026
ANIMAL
2026
ANIMAL
2026
RCT
2025
ANIMAL
2025
META_ANALYSIS
2025
ANIMAL
2025
RCT
2025
OTHER
2025
WGS
2025
ANIMAL
2025
IN_VITRO
2025
REVIEW
2025
IN_VITRO
2025
ANIMAL
2025
ANIMAL
2025
RCT
2024
RCT
2024
RCT
2024
ANIMAL
2024
OBSERVATIONAL
Browse all 237 papers →
Probiotic treatment rescues behavioral deficits and gut microbial abnormalities induced by preconceptional stress in mothers and offspring
· Repository for Publications and Research Data (ETH Zurich)
Effects of live and heat-killed Bifidobacterium lactis in rats with induced periodontitis
· Journal of Applied Oral Science
Two-strain probiotic supplementation ameliorates physiological responses to running in the heat
· Physiology
Probiotic consumption reduces alveolar bone loss and kidney damage in pregnant rats with experimental periodontitis
· Journal of Periodontology
Effectiveness of Oral Microbiome-Targeted Probiotics in Reducing Systemic Inflammation and Periodontal Disease Progression
· Indus journal of bioscience research.
Probiotic-based irrigation solution reduces neutrophil extracellular trap formation and stimulates CRAMP antimicrobial peptide expression in rat teeth with induced periapical lesions
· Clinical Oral Investigations
Efecto adyuvante del metronidazol más amoxicilina versus el probiótico Bifidobacterium lactis HN019 en el tratamiento de la periodontitis estadio II grado A y B.
· Revista de la Asociación Dental Mexicana
Probiotic strain identification and safety assessment of unlabeled bacteria in infant products
· International Journal of Food Microbiology
Development of a Strain-Specific Detection and Quantification Method for Bifidobacterium animalis subsp. lactis HN019 Using WGS-SNP Analysis and qPCR
· Microorganisms
B. lactis HN019 modulates periapical inflammation and enhances cementum repair by increasing CEMP-1 expression in an animal model
· Archives of Oral Biology
SynergisticEffect of Formate and Cell-Free SupernatantFermented by Two Probiotics, Bifidobacterium animalis spp. lactis HN019 and Lacticaseibacillusrhamnosus HN001, against Shigella flexneri Growth
· Figshare
Research Progress on the Correlation between Intelligent Development of Infants and Young Children and Probiotic Intervention
· Advances in Clinical Medicine
Synergistic Effect of Formate and Cell-Free Supernatant Fermented by Two Probiotics, Bifidobacterium animalis spp. lactis HN019 and Lacticaseibacillus rhamnosus HN001, against Shigella flexneri Growth
· ACS Infectious Diseases
Effects of prenatal supplementation with probiotics on the development of experimental periodontitis in pregnant mice
· Journal of Periodontology
Evaluation of the Impact of Probiotic Supplementation on Gingival Inflammation in Subjects Undergoing Orthodontic Treatment with Fixed Appliances or Clear Aligners: A Randomized, Single-Blind Pilot Study
· Dentistry Journal
Effect of an 8‐Week Bifidobacterium lactis HN019 Supplementation on Functional Constipation: A Multi‐Center, Triple‐Blind, Randomized, Placebo‐Controlled Trial
· Molecular Nutrition & Food Research
Effect of caloric restriction with probiotic supplementation on body composition, quality of life, and psychobiological factors of obese men: A randomized, double-blinded placebo-controlled clinical trial
· Clinical Nutrition
Eight-Week Supplementation With Bifidobacterium lactis HN019 and Functional Constipation
· JAMA Network Open
Probiotics enhance alveolar bone microarchitecture, intestinal morphology and estradiol levels in osteoporotic animals
· Journal of Periodontal Research
Avaliação do efeito do consumo de >i<Bifidobacterium animalis lactis HN019>/i< no controle metabólico, microbiota intestinal e na resposta imunológica de indivíduos com diabetes tipo 2
·
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Citations
Selected papers that name this strain.
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[1]
PMID 40320938 →Effect of an 8‐Week Bifidobacterium lactis HN019 Supplementation on Functional Constipation: A Multi‐Center, Triple‐Blind, Randomized, Placebo‐Controlled Trial· Molecular Nutrition & Food Research · 2025
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[2]
Source →Effectiveness of Oral Microbiome-Targeted Probiotics in Reducing Systemic Inflammation and Periodontal Disease Progression· Indus journal of bioscience research. · 2025
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[3]
Source →Susceptibilidade ao desenvolvimento da doença periodontal experimental na prole de camundongos com histórico de suplementação probiótica pré-natal e perinatal· · 2024
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[4]
PMID 39356506 →Eight-Week Supplementation With Bifidobacterium lactis HN019 and Functional Constipation· JAMA Network Open · 2024
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[5]
PMID 37630731 →The Effect of Delivery Matrix on Bifidobacterium animalis subsp. lactis HN019 Survival through In Vitro Human Digestion· Nutrients · 2023
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[6]
PMID 36004715 →Comparison of two probiotics in follow-on formula: Bifidobacterium animalis subsp. lactis HN019 reduced upper respiratory tract infections in Chinese infants· Beneficial Microbes · 2022
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[7]
PMID 36305963 →Effects of oral administration of Bifidobacterium animalis subsp. lactis HN019 on the treatment of plaque-induced generalized gingivitis· Clinical Oral Investigations · 2022
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[8]
Source →Table_1_Bifidobacterium animalis subsp. lactis HN019 Effects on Gut Health: A Review.docx· Figshare · 2021
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[9]
PMID 32960889 →Bifidobacterium animalis subsp lactis HN019 presents antimicrobial potential against periodontopathogens and modulates the immunological response of oral mucosa in periodontitis patients· PLoS ONE · 2020
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[10]
Source →Screening of Bifidobacterium strains to bind with Benzo[a]pyrene under food stress factors and the mechanism of the process· Journal of Food Processing and Preservation · 2019