Strain Profile
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Limosilactobacillus fermentum CECT5716
DEP
CECT5716
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Human-origin
Where this strain was first isolated, curated from the literature and culture-collection catalogs. It describes provenance only — not suitability, and not benefit.
How we classify this →
Sequenced
Whether a public genome assembly is linked for this strain. Without one the genome screens cannot run. It is not a verdict on the organism.
How we classify this →
Public genome assembly available
Limosilactobacillus fermentum CECT5716 (previously classified as Lactobacillus fermentum CECT5716) was originally isolated from human breast milk, an origin that has shaped much of the research into its applications. Human randomized controlled trials include a one-year infant formula supplementation trial and a trial examining its use in breastfeeding women in the context of mastitis prevention. Animal studies have examined this species in the context of gut inflammation, including in high-fat-diet mouse models of obesity-related gut dysbiosis, and in vitro work has characterized its immunomodulatory properties. The strain has been the subject of reviews in pediatric nutrition and is considered relatively well-characterized within the Lactobacillaceae family. These are research topics, not findings; the papers do not establish that this strain treats or prevents any condition.
Where it's been studied Tags come from a conservative keyword scan of each paper's title, abstract, and summary. A tag is research coverage, not measured effect. How we classify this →
Share of this strain's 61 body-system-tagged papers that concern each system. Research coverage, not measured effect.
+3 more systems
Symptoms in the research A tag means the paper's text names the symptom or condition — research coverage, not evidence of benefit. How we classify this →
Share of this strain's 32 symptom-tagged papers that mention each symptom or condition. Research coverage, not evidence of benefit.
Research Study-type filters use AI-classified labels, audited but not guaranteed — check the paper itself before leaning on one. How we classify this →
91 papers reference this strain in the probiotic database.
Match confidence
How strongly this paper was matched to this strain when the corpus was linked. It orders the list — it says nothing about the study's quality or its findings.
How we classify this →
2026
IN_VITRO
2026
OTHER
2026
ANIMAL
2026
IN_VITRO
2025
RCT
2025
IN_VITRO
2025
ANIMAL
2024
ANIMAL
2024
RCT
2023
REVIEW
2022
ANIMAL
2022
RCT
2022
OBSERVATIONAL
2022
ANIMAL
2022
RCT
2021
META_ANALYSIS
2021
REVIEW
2021
ANIMAL
2021
ANIMAL
2021
WGS
Browse all 91 papers →
Effects of milk-based media on the centrifugal recovery and counting of Limosilactobacillus
· Journal of Dairy Science
Inclusion of Limosilactobacillus fermentum CECT5716 in Novel Fermented Caprine Milk: Technological and Nutritional Assessment
· Journal of Agricultural and Food Chemistry
Bioactive Low-Molecular-Weight Fraction from Limosilactobacillus fermentum CECT5716 Attenuates Intestinal Inflammation and Dysbiosis in DSS-Treated Mice
· Nutrients
Inclusion of Limosilactobacillus fermentum CECT5716 in Novel Fermented Caprine Milk: Technological and Nutritional Assessment
· Figshare
L.Fermentum CECT5716 and B.Breve CECT7263 on premature infants morbidities: a randomized clinical trial
· Pediatric Research
Impact of extensively hydrolyzed infant formula on the probiotic and postbiotic properties of Lactobacillus fermentum in an in vitro co-culture model
· Food & Function
The probiotic Limosilactobacillus fermentum CECT5716 enhances the antihypertensive response to hydrochlorothiazide in spontaneously hypertensive rats
· Gut Microbes
Effect of β-glucan from Lactobacillus fermentum on serum lipid profile in rats
· Kufa Journal for Agricultural Sciences
Efficacy and safety of a synbiotic infant formula for the prevention of respiratory and gastrointestinal infections: a randomized controlled trial
· American Journal of Clinical Nutrition
Limosilactobacillus fermentum CECT5716: Clinical Potential of a Probiotic Strain Isolated from Human Milk
· Nutrients
Beneficial Effects of Limosilactobacillus fermentum in the DCA Experimental Model of Irritable Bowel Syndrome in Rats
· Nutrients
Oral Lactobacillus fermentum CECT5716 in the patients with lactational abscess treated by needle aspiration: The late follow-up of a randomized controlled trial
· Medicine
Influence of breast milk probiotics on health of first semi-annual infants
· Medical alphabet
Lactobacillus fermentum CECT5716 Alleviates the Inflammatory Response in Asthma by Regulating TLR2/TLR4 Expression
· Frontiers in Nutrition
Breast microecology improvement using probiotics following needle aspiration in patients with lactational breast abscess: a multi-center randomized double-blind controlled trial
· Scientific Reports
Evaluation of the Effect of Limosilactobacillus fermentum CECT5716 on Gastrointestinal Infections in Infants: A Systematic Review and Meta-Analysis
· Microorganisms
Limosilactobacillus fermentum CECT5716: Mechanisms and Therapeutic Insights
· Nutrients
Probiotics Prevent Hypertension in a Murine Model of Systemic Lupus Erythematosus Induced by Toll-Like Receptor 7 Activation
· Nutrients
Lactobacillus fermentum CECT5716 ameliorates high fat diet-induced obesity in mice through modulation of gut microbiota dysbiosis
· Pharmacological Research
Phylogenetic and Comparative Genomic Analysis of Lactobacillus fermentum Strains and the Key Genes Related to their Intestinal Anti-Inflammatory Effects
· Engineering
Discussion
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Citations
Selected papers that name this strain.
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[1]
PMID 42356278 →Bioactive Low-Molecular-Weight Fraction from Limosilactobacillus fermentum CECT5716 Attenuates Intestinal Inflammation and Dysbiosis in DSS-Treated Mice· Nutrients · 2026
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[2]
PMID 37432320 →Limosilactobacillus fermentum CECT5716: Clinical Potential of a Probiotic Strain Isolated from Human Milk· Nutrients · 2023
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[3]
PMID 36202884 →Breast microecology improvement using probiotics following needle aspiration in patients with lactational breast abscess: a multi-center randomized double-blind controlled trial· Scientific Reports · 2022
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[4]
PMID 34208893 →Evaluation of the Effect of Limosilactobacillus fermentum CECT5716 on Gastrointestinal Infections in Infants: A Systematic Review and Meta-Analysis· Microorganisms · 2021
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[5]
PMID 33801082 →Limosilactobacillus fermentum CECT5716: Mechanisms and Therapeutic Insights· Nutrients · 2021
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[6]
Source →Interventions to improve and evaluate breastfeeding patterns and outcomes in the first year following birth· The Sydney eScholarship Repository (The University of Sydney) · 2020
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[7]
PMID 21873895 →Human Milk Probiotic Lactobacillus fermentum CECT5716 Reduces the Incidence of Gastrointestinal and Upper Respiratory Tract Infections in Infants· Journal of Pediatric Gastroenterology and Nutrition · 2011
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[8]
PMID 20455694 →Treatment of Infectious Mastitis during Lactation: Antibiotics versus Oral Administration of Lactobacilli Isolated from Breast Milk· Clinical Infectious Diseases · 2010