Strain Profile
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Bifidobacterium lactis CNCM I-2494
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Human-origin
Where this strain was first isolated, curated from the literature and culture-collection catalogs. It describes provenance only — not suitability, and not benefit.
How we classify this →
Sequenced
Whether a public genome assembly is linked for this strain. Without one the genome screens cannot run. It is not a verdict on the organism.
How we classify this →
Public genome assembly available
Bifidobacterium lactis CNCM I-2494 (also designated DN-173 010) has been studied primarily in the context of digestive comfort and gut barrier function. Randomized controlled trials and observational studies have examined self-reported digestive discomfort in adults consuming this strain in fermented milk, including in people with irritable bowel syndrome, with individual responses varying and findings not uniform across trials. In vitro and animal research has explored potential mechanisms involving gut immune barrier integrity and stress responses. These are research topics, not findings; the papers do not establish that this strain treats or prevents any condition.
Where it's been studied Tags come from a conservative keyword scan of each paper's title, abstract, and summary. A tag is research coverage, not measured effect. How we classify this →
Share of this strain's 21 body-system-tagged papers that concern each system. Research coverage, not measured effect.
Symptoms in the research A tag means the paper's text names the symptom or condition — research coverage, not evidence of benefit. How we classify this →
Share of this strain's 10 symptom-tagged papers that mention each symptom or condition. Research coverage, not evidence of benefit.
+1 more symptoms
Research Study-type filters use AI-classified labels, audited but not guaranteed — check the paper itself before leaning on one. How we classify this →
24 papers reference this strain in the probiotic database.
Match confidence
How strongly this paper was matched to this strain when the corpus was linked. It orders the list — it says nothing about the study's quality or its findings.
How we classify this →
2024
IN_VITRO
2024
RCT
2023
IN_VITRO
2022
OBSERVATIONAL
2021
OBSERVATIONAL
2021
IN_VITRO
2020
OBSERVATIONAL
2019
RCT
2019
META_ANALYSIS
2016
META_ANALYSIS
2016
RCT
2016
RCT
2016
META_ANALYSIS
2015
REVIEW
2015
IN_VITRO
2015
REVIEW
2014
WGS
2013
RCT
2013
ANIMAL
2013
ANIMAL
Browse all 24 papers →
Honey Varietals Differentially Impact Bifidobacterium animalis ssp. lactis Survivability in Yogurt through Simulated In Vitro Digestion
· Journal of Nutrition
Honey Added to Yogurt with Bifidobacterium animalis subsp. lactis DN-173 010/CNCM I-2494 Supports Probiotic Enrichment but Does Not Reduce Intestinal Transit Time in Healthy Adults: A Randomized, Controlled, Crossover Trial
· Journal of Nutrition
Honey varietals differentially impact Bifidobacterium animalis ssp lactis survivability in yogurt through simulated in vitro digestion
· bioRxiv (Cold Spring Harbor Laboratory)
Human gut metatranscriptome changes induced by a fermented milk product are associated with improved tolerance to a flatulogenic diet
· Computational and Structural Biotechnology Journal
A Fermented Milk Product Containing B. lactis CNCM I-2494 Improves the Tolerance of a Plant-Based Diet in Patients with Disorders of Gut–Brain Interactions
· Nutrients
Determination of Honey Varietals’ Impact on Bifidobacterium animalis ssp lactis Survivability in Commercial Yogurt Through Simulated In Vitro Digestion
· Current Developments in Nutrition
A Fermented Milk Product with B. lactis CNCM I-2494 and Lactic Acid Bacteria Improves Gastrointestinal Comfort in Response to a Challenge Diet Rich in Fermentable Residues in Healthy Subjects
· Nutrients
Fasting breath H2 and gut microbiota metabolic potential are associated with the response to a fermented milk product in irritable bowel syndrome
· PLoS ONE
Consumption of a Fermented Milk Product Containing Bifidobacterium lactis CNCM I-2494 in Women Complaining of Minor Digestive Symptoms: Rapid Response Which Is Independent of Dietary Fibre Intake or Physical Activity
· Nutrients
Tu1095 Systematic Review and Meta-Analysis: The Effects of Fermented Milk With Bifidobacterium lactis CNCM I-2494 and Lactic Acid Bacteria on Gastro-Intestinal Discomfort in the General Adult Population
· Gastroenterology
REDUCTION OF SYMPTOMS AND BREATH H2 PRODUCTION IN A SUBGROUP OF PATIENTS WITH IRRITABLE BOWEL SYNDROME CHARACTERIZED BY DISTINCT GUT MICROBIOTA ACTIVITY: EFFECT OF A FERMENTED MILK PRODUCT CONTAINING BIFIDOBACTERIUM LACTIS CNCM I-2494
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Mo1322 Effect of a Fermented Milk Product Containing Bifidobacterium lactis CNCM I-2494 in Patients With Irritable Bowel Syndrome (IBS): A Randomized, Double-Blinded, Placebo-Controlled Trial
· Gastroenterology
Systematic review and meta-analysis: the effects of fermented milk with Bifidobacterium lactis CNCM I-2494 and lactic acid bacteria on gastrointestinal discomfort in the general adult population
· Therapeutic Advances in Gastroenterology
THE EFFECT OF PROBIOTIC FERMENTED MILK THAT INCLUDES BIFIDOBACTERIUM LACTIS CNCM I-2494 ON THE REDUCTION OF GASTROINTESTINAL DISCOMFORT AND SYMPTOMS IN ADULTS: A NARRATIVE REVIEW.
· PubMed
Sa2030 Fermented Milk Product Containing B. Lactis CNCM I-2494 Improves Gut Barrier Function via Regulatory-Th17 Immune Pathway
· Gastroenterology
The effect of probiotic fermented milk that includes Bifidobacterium lactis CNCM I-2494 on the reduction of gastrointestinal discomfort and symptoms in adults: a narrative review
· LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)
Identification of Restriction-Modification Systems of Bifidobacterium animalis subsp. lactis CNCM I-2494 by SMRT Sequencing and Associated Methylome Analysis
· PLoS ONE
A randomized, double‐blind, controlled study and pooled analysis of two identical trials of fermented milk containing probiotic Bifidobacterium lactis CNCM I‐2494 in healthy women reporting minor digestive symptoms
· Neurogastroenterology & Motility
Mo2010 Fermented Milk Containing Bifidobacterium Lactis CNCM I-2494 Suppresses Gut Visceral Hypersensitivity Promoted by Both Acute and Chronic Stress in Rat
· Gastroenterology
Tu1966 Protective Effect of a Fermented Milk Dairy Product Containing Bifidobactrium Lactis CNCM I-2494 on Gut Immune Barrier Impairment Promoted by Acute Stress in Rats
· Gastroenterology
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Citations
Selected papers that name this strain.
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[1]
PMID 30621211 →Consumption of a Fermented Milk Product Containing Bifidobacterium lactis CNCM I-2494 in Women Complaining of Minor Digestive Symptoms: Rapid Response Which Is Independent of Dietary Fibre Intake or Physical Activity· Nutrients · 2019
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[2]
PMID 30946757 →Fasting breath H2 and gut microbiota metabolic potential are associated with the response to a fermented milk product in irritable bowel syndrome· PLoS ONE · 2019
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[3]
PMID 28286561 →Systematic review and meta-analysis: the effects of fermented milk with Bifidobacterium lactis CNCM I-2494 and lactic acid bacteria on gastrointestinal discomfort in the general adult population· Therapeutic Advances in Gastroenterology · 2016
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[4]
PMID 26268077 →THE EFFECT OF PROBIOTIC FERMENTED MILK THAT INCLUDES BIFIDOBACTERIUM LACTIS CNCM I-2494 ON THE REDUCTION OF GASTROINTESTINAL DISCOMFORT AND SYMPTOMS IN ADULTS: A NARRATIVE REVIEW.· PubMed · 2015
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[5]
PMID 23480238 →A randomized, double‐blind, controlled study and pooled analysis of two identical trials of fermented milk containing probiotic Bifidobacterium lactis CNCM I‐2494 in healthy women reporting minor digestive symptoms· Neurogastroenterology & Motility · 2013