Strain Profile
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Lactobacillus rhamnosus CNCM I-3690
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Food-origin
Where this strain was first isolated, curated from the literature and culture-collection catalogs. It describes provenance only — not suitability, and not benefit.
How we classify this →
Sequenced
Whether a public genome assembly is linked for this strain. Without one the genome screens cannot run. It is not a verdict on the organism.
How we classify this →
Public genome assembly available
Lacticaseibacillus rhamnosus CNCM I-3690 has been studied across a range of outcomes with a mix of animal, in vitro, and human RCT evidence. Animal studies have examined the strain's relationship to intestinal barrier integrity, mucus production, and cytoprotective responses, and one study examined lifespan in a Caenorhabditis elegans oxidative-stress model. Multiple randomized controlled trials evaluated CNCM I-3690 as part of multi-strain fermented milk formulations, examining gut microbiota recovery after Helicobacter pylori antibiotic therapy and microbiome resilience. A separate human RCT examined subjective stress scores in healthy adults in connection with gut-brain axis activity. These are research topics, not findings; the papers do not establish that this strain treats or prevents any condition.
Where it's been studied Tags come from a conservative keyword scan of each paper's title, abstract, and summary. A tag is research coverage, not measured effect. How we classify this →
Share of this strain's 16 body-system-tagged papers that concern each system. Research coverage, not measured effect.
Symptoms in the research A tag means the paper's text names the symptom or condition — research coverage, not evidence of benefit. How we classify this →
Share of this strain's 8 symptom-tagged papers that mention each symptom or condition. Research coverage, not evidence of benefit.
+1 more symptoms
Research Study-type filters use AI-classified labels, audited but not guaranteed — check the paper itself before leaning on one. How we classify this →
16 papers reference this strain in the probiotic database.
Match confidence
How strongly this paper was matched to this strain when the corpus was linked. It orders the list — it says nothing about the study's quality or its findings.
How we classify this →
2025
OBSERVATIONAL
2023
ANIMAL
2023
OBSERVATIONAL
2023
RCT
2022
RCT
2022
RCT
2021
RCT
2021
RCT
2021
RCT
2020
RCT
2019
ANIMAL
2014
ANIMAL
2013
IN_VITRO
2012
ANIMAL
2018
ANIMAL
2017
ANIMAL
Browse all 16 papers →
Probiotic-mediated modulation of gut microbiome in students exposed to academic stress: a randomized controlled trial
· npj Biofilms and Microbiomes
Over-production of exopolysaccharide by Lacticaseibacillus rhamnosus CNCM I-3690 strain cutbacks its beneficial effect on the host
· Scientific Reports
L. rhamnosus CNCM I-3690 survival, adaptation, and small bowel microbiome impact in human
· Gut Microbes
Endogenous small intestinal microbiome determinants of transient colonisation efficiency by bacteria from fermented dairy products: a randomised controlled trial
· Microbiome
Improved gut microbiome recovery following drug therapy is linked to abundance and replication of probiotic strains
· Gut Microbes
Lactobacillus rhamnosus CNCM I-3690 decreases subjective academic stress in healthy adults: a randomized placebo-controlled trial
· Gut Microbes
Multi-strain fermented milk promotes gut microbiota recovery after Helicobacter pylori therapy: a randomised, controlled trial
· medRxiv
A Randomised, Controlled Trial: Effect of a Multi-Strain Fermented Milk on the Gut Microbiota Recovery after Helicobacter pylori Therapy
· Nutrients
Endogenous Small Intestinal Microbiome Determinants of Transient Colonization Efficiency by Bacteria from Fermented Dairy Products; A Randomized Controlled Trial
· Research Square
Safety and functional enrichment of gut microbiome in healthy subjects consuming a multi-strain fermented milk product: a randomised controlled trial
· Scientific Reports
The potential probiotic Lactobacillus rhamnosus CNCM I-3690 strain protects the intestinal barrier by stimulating both mucus production and cytoprotective response
· Scientific Reports
Lactobacillus rhamnosus CNCM I-3690 and the commensal bacterium Faecalibacterium prausnitzii A2-165 exhibit similar protective effects to induced barrier hyper-permeability in mice
· Gut Microbes
Caractérisation et analyse des effets probiotiques de souches de Lactobacillus et de Bifidobacterium
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Anti-Inflammatory Lactobacillus rhamnosus CNCM I-3690 Strain Protects against Oxidative Stress and Increases Lifespan in Caenorhabditis elegans
· PLoS ONE
Bilophila wadsworthia aggravates high fat diet induced metabolic dysfunctions in mice
· Nature Communications
Impact de l'administration des probiotiques sur les infections respiratoires
· ZooKeys
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Citations
Selected papers that name this strain.
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[1]
PMID 40691449 →Probiotic-mediated modulation of gut microbiome in students exposed to academic stress: a randomized controlled trial· npj Biofilms and Microbiomes · 2025
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[2]
PMID 36879297 →Endogenous small intestinal microbiome determinants of transient colonisation efficiency by bacteria from fermented dairy products: a randomised controlled trial· Microbiome · 2023
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[3]
PMID 35130109 →Lactobacillus rhamnosus CNCM I-3690 decreases subjective academic stress in healthy adults: a randomized placebo-controlled trial· Gut Microbes · 2022
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[4]
PMID 35916669 →Improved gut microbiome recovery following drug therapy is linked to abundance and replication of probiotic strains· Gut Microbes · 2022
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[5]
Source →Endogenous Small Intestinal Microbiome Determinants of Transient Colonization Efficiency by Bacteria from Fermented Dairy Products; A Randomized Controlled Trial· Research Square · 2021
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[6]
PMID 34579049 →A Randomised, Controlled Trial: Effect of a Multi-Strain Fermented Milk on the Gut Microbiota Recovery after Helicobacter pylori Therapy· Nutrients · 2021
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[7]
Source →Multi-strain fermented milk promotes gut microbiota recovery after Helicobacter pylori therapy: a randomised, controlled trial· medRxiv · 2021
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[8]
PMID 32994487 →Safety and functional enrichment of gut microbiome in healthy subjects consuming a multi-strain fermented milk product: a randomised controlled trial· Scientific Reports · 2020