Strain Profile
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Bifidobacterium infantis 35624
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Human-origin
Where this strain was first isolated, curated from the literature and culture-collection catalogs. It describes provenance only — not suitability, and not benefit.
How we classify this →
Sequenced
Whether a public genome assembly is linked for this strain. Without one the genome screens cannot run. It is not a verdict on the organism.
How we classify this →
Public genome assembly available
Bifidobacterium infantis 35624 (also marketed as Bifantis) is one of the more thoroughly studied probiotic strains in the Bifidobacterium genus. Multiple randomized controlled trials and a meta-analysis have examined its role in irritable bowel syndrome (IBS), a functional gut disorder characterized by abdominal pain and altered bowel habits. Animal research has examined immunomodulatory activity, including mechanisms involving regulatory immune cells and anti-inflammatory signaling, documented in laboratory and animal settings. A 2013 human RCT examined fecal colonization following oral supplementation, and a 2017 RCT in collegiate swimmers examined inflammatory markers. These are research topics, not findings; the papers do not establish that this strain treats or prevents any condition.
Where it's been studied Tags come from a conservative keyword scan of each paper's title, abstract, and summary. A tag is research coverage, not measured effect. How we classify this →
Share of this strain's 104 body-system-tagged papers that concern each system. Research coverage, not measured effect.
+3 more systems
Symptoms in the research A tag means the paper's text names the symptom or condition — research coverage, not evidence of benefit. How we classify this →
Share of this strain's 68 symptom-tagged papers that mention each symptom or condition. Research coverage, not evidence of benefit.
+3 more symptoms
Research Study-type filters use AI-classified labels, audited but not guaranteed — check the paper itself before leaning on one. How we classify this →
151 papers reference this strain in the probiotic database.
Match confidence
How strongly this paper was matched to this strain when the corpus was linked. It orders the list — it says nothing about the study's quality or its findings.
How we classify this →
REVIEW
2026
ANIMAL
2025
ANIMAL
2025
REVIEW
2025
REVIEW
2025
RCT
2024
OBSERVATIONAL
2024
OBSERVATIONAL
2024
RCT
2023
RCT
2023
OBSERVATIONAL
2023
REVIEW
2022
RCT
2022
OBSERVATIONAL
2022
OBSERVATIONAL
2021
RCT
2021
IN_VITRO
2021
RCT
2021
REVIEW
2020
ANIMAL
Browse all 151 papers →
Efficacy of Probiotics in the Treatment of Patients with Irritable Bowel Syndrome: Focus on Bifidobacterium longum 35624
Эффективность пробиотиков в лечении пациентов с синдромом раздраженного кишечника: фокус на Bifidobacterium longum 35624
· CyberLeninK (CyberLeninka)
Investigation of the changes in gut microbiota in high-fat-diet-induced obesity in rats with and without the probiotic supplementation Bifidobacterium infantis 35624
· Journal of Investigative Medicine
Study on Healing Effects of Bifidobacterium Infantis 35624 in Inflammatory and Energy Metabolism Parameters in High-Fat-Diet-Induced Obesity in Rat Model
· Journal of Food and Nutrition Research
Probióticos en la modulación de los síntomas del síndrome de intestino irritable: revisión bibliográfica.
· MQRInvestigar
Síndrome de intestino irritable como modelo de trastornos gastrointestinales funcionales: revisión sistemática sobre su vínculo con la microbiota intestinal y el uso de coadyuvantes de probióticos, prebióticos y dieta FODMAPs
· TITULA
Efficacy of the Probiotic Bifidobacterium infantis 35624 in Functional Abdominal Bloating: A Triple-Blind, Randomized Controlled Trial
· SN Comprehensive Clinical Medicine
Effects of Bifidobacterium longum 35624 in Children and Adolescents with Irritable Bowel Syndrome
· Nutrients
Effects of Bifidobacterium longum longum 35624® on the Symptoms and Quality of Life in Patients with Irritable Bowel Syndrome: Results of the Multicenter Observational Program SAGA
· Russian Journal of Gastroenterology Hepatology Coloproctology
The major mechanisms of disruption of the arginine/citrulline cycle in the pathogenesis of cytostatic-induced intestinal injury in patients with chronic lymphoproliferative diseases and methods of their correction
· Modern Gastroenterology
#5 – ENSAYO CLÍNICO ABIERTO QUE INVESTIGA EL EFECTO DE BIFIDOBACTERIUM LONGUM 35624™ EN SÍNTOMAS GASTROINTESTINALES E IMPACTO EN LA VIDA DIARIA EN NIÑOS CON TRASTORNOS GASTROINTESTINALES FUNCIONALES
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An 8-Week Course of Bifidobacterium longum 35624® Is Associated with a Reduction in the Symptoms of Irritable Bowel Syndrome
· Probiotics and Antimicrobial Proteins
Long-term probiotic administration for irritable bowel syndrome: a legal need
· Terapevticheskii arkhiv
La microbiota bacteriana fecal en pacientes estreñidos previa y posterior a ocho semanas de administración diaria de Bifidobacterium infantis 35624
· Revista de Gastroenterología de México
Effect of Bifidobacterium longum 35624 on disease severity and quality of life in patients with irritable bowel syndrome
· World Journal of Gastroenterology
Fecal bacterial microbiota in constipated patients before and after eight weeks of daily Bifidobacterium infantis 35624 administration
· Revista de Gastroenterología de México (English Edition)
Correction of Large Intestine Dysbiosis and Its Effect on the Dynamics of Free Amino Acid Levels in Blood Serum in Patients with Chronic Pancreatitis and Type 2 Diabetes Mellitus
Корекція дисбіозу товстої кишки та її вплив на динаміку рівнів вільних амінокислот у сироватці крові у хворих на хронічний панкреатит та цукровий діабет 2-го типу
· Терапевтика
An Exopolysaccharide Produced by Bifidobacterium longum 35624® Inhibits Osteoclast Formation via a TLR2-Dependent Mechanism
· Calcified Tissue International
PTH-103 Bifidobacterium longum 35624(R)and1714(R) in adults with Irritable Bowel Syndrome–relationships to symptom severity and co-morbidity
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Unique strain of Bifidobacterium longum and its efficacy in irritable bowel syndrome
· Meditsinskiy sovet = Medical Council
Probiotic treatment (Bifidobacterium longum subsp. longum 35624™) affects stress responsivity in male rats after chronic corticosterone exposure
· Behavioural Brain Research
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Citations
Selected papers that name this strain.
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[1]
Source →PTH-103 Bifidobacterium longum 35624(R)and1714(R) in adults with Irritable Bowel Syndrome–relationships to symptom severity and co-morbidity· · 2021
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[2]
Source →Organoid-derived adult human colonic epithelium responds to co-culture with a probiotic strain of Bifidobacterium longum· bioRxiv (Cold Spring Harbor Laboratory) · 2020
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[3]
PMID 29726281 →Exopolysaccharide from Bifidobacterium longum subsp. longum 35624™ modulates murine allergic airway responses· Beneficial Microbes · 2018
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[4]
PMID 27736791 →The Surface-Associated Exopolysaccharide of Bifidobacterium longum 35624 Plays an Essential Role in Dampening Host Proinflammatory Responses and Repressing Local T H 17 Responses· Applied and Environmental Microbiology · 2016
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[5]
PMID 26832746 →Safety and acceptability of Lactobacillus reuteri DSM 17938 and Bifidobacterium longum subspecies infantis 35624 in Bangladeshi infants: a phase I randomized clinical trial· BMC Complementary and Alternative Medicine · 2015
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[6]
Source →Síndrome del intestino irritable: papel del sistema inmune y de los probióticos· Dialnet (Universidad de la Rioja) · 2014
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[7]
PMID 23704880 →Immunomodulation by Bifidobacterium infantis 35624 in the Murine Lamina Propria Requires Retinoic Acid-Dependent and Independent Mechanisms· PLoS ONE · 2013
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[8]
PMID 23842110 →Bifidobacterium infantis 35624 modulates host inflammatory processes beyond the gut· Gut Microbes · 2013
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[9]
PMID 22052061 →Bifidobacterium infantis 35624 administration induces Foxp3 T regulatory cells in human peripheral blood: potential role for myeloid and plasmacytoid dendritic cells· Gut · 2011
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[10]
Source →Probiotic Bifidobacterium longum subsp. infantis 35624 in a Non-patient Population with a History of Abdominal Discomfort and Bloating· The American Journal of Gastroenterology · 2011