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Clostridium leptum

◑ Environmental
Sequenced
Public genome assembly available

Clostridium leptum is an anaerobic gut bacterium that belongs to a numerically significant group of microbes in the human intestine, often used as a biomarker in microbiome composition studies. It is not a probiotic strain; rather, it appears in the literature as a phylogenetic marker for characterizing the Clostridium leptum subgroup (also known as Clostridium cluster IV), which is discussed in relation to butyrate production in the colon. Observational studies have examined this cluster in relation to conditions including irritable bowel syndrome and inflammatory bowel disease. Research interest in C. leptum is primarily ecological and taxonomic rather than interventional. These are research topics, not findings; the papers do not establish that this strain treats or prevents any condition.

Where it's been studied

Share of this strain's 281 body-system-tagged papers that concern each system. Research coverage, not measured effect.

+5 more systems

Symptoms in the research

Share of this strain's 103 symptom-tagged papers that mention each symptom or condition. Research coverage, not evidence of benefit.

+9 more symptoms

Research

350 papers reference this strain in the probiotic database.

Match confidence
OTHER
Analysis of the Human Resident Microbiota by Quantitative RT-PCR
定量的RT-PCR法によるヒト常在細菌叢の解析
· Institutional Repositories DataBase (IRDB)
2025 OTHER
Clostridium leptum Moore et al. 1976
· BacDive
2025 ANIMAL
Clostridium leptum attenuates allergic airway inflammation via tDC‒Treg axis activation in a murine model of gut dysbiosis-associated asthma
· Scientific Reports
2025 IN_VITRO
Cell-free supernatant of Clostridium leptum inhibits breast cancer cell proliferation
· Letters in Applied Microbiology
2025 ANIMAL
Abstract 1525 A dynamic dehydrogenase: structural analysis of the carboxyspermidine dehydrogenase catalytic cycle
· Journal of Biological Chemistry
2025 IN_VITRO
Structure of Clostridium leptum carboxyspermidine decarboxylase and comparison to homologs prevalent within the human gut microbiome
· Acta Crystallographica Section F Structural Biology Communications
2024 WGS
Genomic Reconstruction and Dietary Response Assessment of Three Clostridium leptum-related Bacteria Isolated from Fecal Samples of Singapore Subjects
· bioRxiv (Cold Spring Harbor Laboratory)
2024 ANIMAL
Metabolites of Clostridium leptum fermenting flaxseed polysaccharide alleviate obesity in rats
· International Journal of Biological Macromolecules
2024 IN_VITRO
An efficient cre‐based workflow for genomic integration and expression of large biosynthetic pathways in Eubacterium limosum
· Biotechnology and Bioengineering
2024 OBSERVATIONAL
Features of the parietal and cavity intestinal microbiota in infants born to mothers with bronchial asthma, depending on the mode of delivery
· Meditsinskiy sovet = Medical Council
2024 IN_VITRO
A highly efficient Cre-based Clostridial workflow for genomic integration and expression of large biosynthetic pathways
·
2022 IN_VITRO
mPPases create a conserved anionic membrane fingerprint as identified via multi-scale simulations
· PLoS Computational Biology
2022 REVIEW
Probiotic Potential of Clostridium spp.—Advantages and Doubts
· Current Issues in Molecular Biology
2021 ANIMAL
Characterization of Carboxynorspermidine Dehydrogenase from Two Human Gut Microbes
· The FASEB Journal
2016 OBSERVATIONAL
Bile Acids and Dysbiosis in Non-Alcoholic Fatty Liver Disease
· PLoS ONE
2015 ANIMAL
Early-Life Exposure to Clostridium leptum Causes Pulmonary Immunosuppression
· PLoS ONE
2014 OTHER
Intestine-derived Clostridium leptum induces murine tolerogenic dendritic cells and regulatory T cells in vitro
· Human Immunology
2013 OTHER
Nomenclature Abstract for Clostridium leptum Moore et al. 1976 (Approved Lists 1980).
· The NamesforLife Abstracts
2012 OTHER
Effect of oral feeding with Clostridium leptum on regulatory T-cell responses and allergic airway inflammation in mice
· Annals of Allergy Asthma & Immunology
2009 OTHER
The application of T-RFLP in analyzing Clostridium leptum group in human gut microbiota.
· Zhongguo weishengtaixue zazhi
Browse all 350 papers →

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Citations

Selected papers that name this strain.

  1. [1]
    Gut microbiome responses to dietary intervention with hypocholesterolemic vegetable oils
    · npj Biofilms and Microbiomes · 2022
    PMID 35411007 →
  2. [2]
    Effect of triple viable capsule combined with antibiotic therapy on the inflammatory factors and intestinal mucosal barrier function in patients with spontaneous bacterial peritonitis
    · DOAJ (DOAJ: Directory of Open Access Journals) · 2018
    Source →