Strain Profile
· NCBI Species Taxon
1492
NCBI Taxonomy's node for this strain's species, not for the strain itself — NCBI has no strain-level node for it. A different identifier from the culture-collection deposit numbers below, which name a physical stock rather than a taxonomic node.
How we classify this →
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Clostridium butyricum
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Environmental
Where this strain was first isolated, curated from the literature and culture-collection catalogs. It describes provenance only — not suitability, and not benefit.
How we classify this →
Sequenced
Whether a public genome assembly is linked for this strain. Without one the genome screens cannot run. It is not a verdict on the organism.
How we classify this →
Public genome assembly available
Clostridium butyricum is a spore-forming anaerobic bacterium capable of producing butyric acid through fermentation. Research has examined this organism across multiple contexts: biotechnological applications in chemical production (butyric acid, 1,3-propanediol), detection methods in food such as cheese fermentation, and epidemiological reports in human disease, including rare botulism cases and associations with neonatal necrotizing enterocolitis. In vitro studies have examined potential applications in cell culture models. The species also occurs naturally in fermented foods and some members are studied for potential microbiota applications, though pathogenic strains have been documented. These are research topics, not findings; the papers do not establish that this strain treats or prevents any condition.
Where it's been studied Tags come from a conservative keyword scan of each paper's title, abstract, and summary. A tag is research coverage, not measured effect. How we classify this →
Share of this strain's 1,010 body-system-tagged papers that concern each system. Research coverage, not measured effect.
Symptoms in the research A tag means the paper's text names the symptom or condition — research coverage, not evidence of benefit. How we classify this →
Share of this strain's 350 symptom-tagged papers that mention each symptom or condition. Research coverage, not evidence of benefit.
+16 more symptoms
Research Study-type filters use AI-classified labels, audited but not guaranteed — check the paper itself before leaning on one. How we classify this →
3072 papers reference this strain in the probiotic database.
Match confidence
How strongly this paper was matched to this strain when the corpus was linked. It orders the list — it says nothing about the study's quality or its findings.
How we classify this →
OTHER
2026
ANIMAL
2026
ANIMAL
2026
OBSERVATIONAL
2026
ANIMAL
2026
OBSERVATIONAL
2026
REVIEW
2026
ANIMAL
2026
OTHER
2026
ANIMAL
2026
META_ANALYSIS
2026
ANIMAL
2026
RCT
2026
ANIMAL
2026
ANIMAL
2026
ANIMAL
2026
META_ANALYSIS
2026
RCT
2026
OTHER
2026
ANIMAL
Browse all 3,072 papers →
Enhancement of Immune Checkpoint Inhibitor Efficacy by Combination Therapy with Levofloxacin and Clostridium butyricum MIYAIRI 588
レボフロキサシンとClostridium butyricum MIYAIRI 588の併用療法による免疫チェックポイント阻害薬の効果増強
· Institutional Repositories DataBase (IRDB)
Clostridium butyricum and its metabolite spermidine delay cognitive decline during natural brain aging by reducing inflammation and oxidative stress
· Behavioural Brain Research
P0158 Clostridium butyricum regulates T-helper 17 cells-related immune response in dextran sodium sulfate-induced colitis mice by targeting Toll-like receptor 2
· Journal of Crohn s and Colitis
A probiotic bacterium modulates antitumour γδ T-cell responses in lung cancer
· Frontiers in Immunology
Exploring the potential for competitive exclusion of commensal probiotic candidates against the insidious swine pathogen Brachyspira hyodysenteriae
· Animal Microbiome
Oxygen-driven nebulization of Clostridium butyricum prevents drug-resistant bacterial pneumonia
· Applied Microbiology and Biotechnology
Potential Health Benefits of Probiotic Strains of Clostridium butyricum
· Applied Microbiology
Effectiveness of probiotic supplementation on growth performance, gut microbiota, and Salmonella reduction in broiler chicks challenged with Salmonella Typhimurium
· Scientific Reports
Clostridium butyricum alleviates DSS-induced colitis by suppressing neutrophil extracellular trap formation via the IL-17 pathway
· International Immunopharmacology
Metagenomic insights into the effects of Clostridium butyricum and Bacillus subtilis probiotics on the gut microbiome and metabolic pathways of industrial broilers in Thailand
· Poultry Science
Recent advances in the positive role of Clostridium in autoimmune diseases: as a crucial regulator of restoring immune-metabolic equilibrium
· Frontiers in Immunology
Fermented Clostridium butyricum GKB7 Inhibits Osteoarthritis Induced by Anterior Cruciate Ligament Transection in a Preclinical Model
· International Journal of Medical Sciences
Long-term clinical outcomes with Clostridium butyricum MIYAIRI 588 (CBM588) and TOPOSCORE assessment in patients receiving immune checkpoint inhibitor (ICI)-based combinations for metastatic renal cell carcinoma (mRCC).
· Journal of Clinical Oncology
Combined Dietary Supplementation of Bacillus subtilis DSM 29784 and a Phytogenic Blend Modulates the Microbiome-Gut-Bone Axis in Broilers
· bioRxiv (Cold Spring Harbor Laboratory)
Antimicrobial peptides produced by Clostridium butyricum alleviate LPS-induced intestinal injury in piglet by modulating gut microbiota, bile acid, and GPR43-NLRP3 pathway
· Animal Nutriomics
A Giant Cervical Decidual Polyp in Pregnancy Managed With Lactoferrin, Probiotics, and Ligation: A Case Report
· Clinical Case Reports
Reviewer response for version 3
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First results of a dose-escalation study evaluating Clostridium butyricum MIYAIRI 588 (CBM588) with nivolumab/ipilimumab (nivo/ipi) in metastatic renal cell carcinoma (mRCC).
· Journal of Clinical Oncology
Clostridium butyricum WF4-2 in Enhancing Growth and Immunity of Red Claw Crayfish (Cherax quadricarinatus)
· Figshare
Effects of extracellular vesicles of Clostridium butyricum on migration, PANoptosis, and macrophage polarization in lipopolysaccharide-induced RAW264.7 macrophages
· Asia-Pacific Journal of Molecular Biology and Biotechnology
Discussion
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Citations
Selected papers that name this strain.
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[1]
PMID 42070310 →Clostridium butyricum alleviates DSS-induced colitis by suppressing neutrophil extracellular trap formation via the IL-17 pathway· International Immunopharmacology · 2026
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[2]
PMID 42121542 →Clostridium butyricum WL-53 Ameliorates High-Fat-Diet-Induced Obesity and Inflammatory Response in Mice by Regulating the Intestinal Microbiota and Liver Metabolism· Foods · 2026
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[3]
PMID 41789065 →The role of Clostridium butyricum and its metabolites in modulating gut mucosal immunity: implications for viral infections and inflammatory diseases· Frontiers in Immunology · 2026
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[4]
PMID 41845196 →Genome-resolved, preclinical safety evaluation of infant-derived Clostridium butyricum S-45-5 as a probiotic candidate· BMC Microbiology · 2026
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[5]
PMID 41459210 →Gut–lung axis in allergic rhinitis: microbial dysbiosis and therapeutic strategies· Frontiers in Microbiology · 2025
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[6]
PMID 40398744 →Clostridium butyricum and its metabolites regulate macrophage polarization through miR-146a to antagonize gouty arthritis· Journal of Advanced Research · 2025
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[7]
PMID 39745177 →Hypoglycemic effect of C. butyricum-pMTL007-GLP-1 engineered probiotics on type 2 diabetes mellitus· Gut Microbes · 2025
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[8]
PMID 41250189 →Advances in understanding the role of gut microbiota in fat deposition and lipid metabolism· Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · 2025
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[9]
PMID 40633539 →Perioperative administration of CBM588 in colorectal cancer radical surgery: A single-center, randomized controlled trial· Cell Reports Medicine · 2025
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[10]
PMID 36093451 →Reoccurrence of takotsubo cardiomyopathy induced by osimertinib: A case report· Clinical Case Reports · 2022