Strain Profile
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Clostridium tyrobutyricum

◑ Environmental
Sequenced
Public genome assembly available

Clostridium tyrobutyricum is an anaerobic, spore-forming bacterium studied primarily for its industrial fermentation properties, specifically its high-yield production of butyric acid from sugars, which has made it a subject of metabolic engineering research for bio-based chemical production. It is also recognized as a spoilage organism in silage and dairy products, and occurs naturally in cattle feed. C. tyrobutyricum is not a recognized probiotic organism; the available research reflects industrial biotechnology and food safety contexts. Butyrate, the salt of butyric acid, is a short-chain fatty acid studied in relation to gut epithelial health, but the organism itself is not characterized for safe human administration, and no probiotic safety or efficacy data were identified in the indexed literature. These are research topics, not findings; the papers do not establish that this strain treats or prevents any condition.

Where it's been studied

Share of this strain's 66 body-system-tagged papers that concern each system. Research coverage, not measured effect.

+3 more systems

Symptoms in the research

Share of this strain's 16 symptom-tagged papers that mention each symptom or condition. Research coverage, not evidence of benefit.

+5 more symptoms

Research

440 papers reference this strain in the probiotic database.

Match confidence
WGS
Characterization of Clostridium spp. causing late blowing in cheese
· BOK:ePub (Universitätsbibliothek der Universität f Bodenkultur Wien)
2026 IN_VITRO
Gas‐Producing Bacteria Causing Package Swelling in Hubei Broad Bean Paste: Isolation, Identification, and Control
· Journal of Food Science
2026 IN_VITRO
A Hybrid SystemBased on Carbon Quantum Dots and Clostridium tyrobutyricum Promotes NADH Conversionand Enhances Butyrate Production
· Figshare
2026 OTHER
A Hybrid System Based on Carbon Quantum Dots and Clostridium tyrobutyricum Promotes NADH Conversion and Enhances Butyrate Production
· ACS Sustainable Chemistry & Engineering
2026 IN_VITRO
GreenProScale - Prozessintegration und Scale-Up einer Grünschnitt-Bioraffinierie unter Berücksichtigung der Robustheit des Systems
· TIB Repositorium
2026 IN_VITRO
Light‐Driven Butyrate Production by a Probiotic Clostridium tyrobutyricum Enabled by a Cell‐Semiconductor Hybrid Interface
· Food Chemistry International
2026 IN_VITRO
Engineering FeoB-Mediated Iron Uptake Enhances Butyrate Fermentation in Clostridium tyrobutyricum
· ACS Synthetic Biology
2026 IN_VITRO
Engineering Clostridium Tyrobutyricum for High Butanol Production through Induction Expression of Exogenous NADPH-Dependent HBD
· ACS Synthetic Biology
2025 OTHER
High-Yield Butyric Acid Production by Lactiplantibacillus Plantarum and Clostridium Tyrobutyricum Co-Encapsulated in Gelatin–Xylan Microcapsules: Preparation and in Vitro Fermentation Characteristics
· SSRN Electronic Journal
2025 OTHER
Clostridium tyrobutyricum van Beynum and Pette 1935
· BacDive
2025 WGS
Clostridium tyrobutyricum strains exhibit high genetic diversity and differ in their ability to cause late blowing defect in washed-curd cheese
· Journal of Dairy Science
2025 IN_VITRO
Systems Metabolic Engineering of Clostridium tyrobutyricum for 1,3‐Propanediol Production From Crude Glycerol
· Biotechnology and Bioengineering
2025 IN_VITRO
Integrated co-cultivation and subsequent esterification: Harnessing Saccharomyces cerevisiae and Clostridium tyrobutyricum for streamlined ester production
· Biotechnology for Biofuels and Bioproducts
2025 OTHER
Metabolic engineering of Clostridium tyrobutyricum for hexanoic acid and hexanol production
· Bioresource Technology
2025 OTHER
Construction of Semi-Artificial Photosynthetic System Based on Engineered Clostridium Tyrobutyricum  And CDS Nanoparticles to Boost Butyrate Synthesis
· SSRN Electronic Journal
2025 OTHER
P12-25 Integrating in vitro digestion and peptidomics into novel food allergenicity assessment: A study on Clostridium tyrobutyricum biomass
· Toxicology Letters
2025 IN_VITRO
Metabolic Engineering of Clostridium tyrobutyricum for High-Yield n-Butanol Production by Increasing Intracellular Reducing Equivalent with NADPH-Dependent 3-Hydroxybutyryl-CoA Dehydrogenase
· ACS Synthetic Biology
2025 IN_VITRO
Integrating in vitro digestion and peptidomics into novel food allergenicity assessment: A study on Clostridium tyrobutyricum biomass
· Current Research in Food Science
2025 OTHER
Construction of dynamic down-regulation systems in Clostridium tyrobutyricum for butyrate production
· Process Biochemistry
2025 OTHER
Optimizing butyric acid production in Clostridium tyrobutyricum through adaptive laboratory evolution and seed propagation fermentation strategies
·
Browse all 440 papers →

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Citations

Selected papers that name this strain.

  1. [1]
    Microbiome dysbiosis in patients with chronic endometritis and Clostridium tyrobutyricum ameliorates chronic endometritis in mice
    · Scientific Reports · 2024
    PMID 38816643 →
  2. [2]
    Clostridium tyrobutyricum in Combination with Chito-oligosaccharides Modulate Inflammation and Gut Microbiota for Inflammatory Bowel Disease Treatment
    · Journal of Agricultural and Food Chemistry · 2024
    PMID 39099138 →
  3. [3]
    DataSheet_1_A Potential Probiotic for Diarrhea: Clostridium tyrobutyricum Protects Against LPS-Induced Epithelial Dysfunction via IL-22 Produced By Th17 Cells in the Ileum.xlsx
    · Figshare · 2021
    Source →
  4. [4]
    DataSheet_2_A Potential Probiotic for Diarrhea: Clostridium tyrobutyricum Protects Against LPS-Induced Epithelial Dysfunction via IL-22 Produced By Th17 Cells in the Ileum.pdf
    · Figshare · 2021
    Source →
  5. [5]
    The Gut Microbiota and Developmental Programming of the Testis in Mice
    · PLoS ONE · 2014
    PMID 25118984 →