Eubacterium coprostanoligenes
Eubacterium coprostanoligenes is an anaerobic gut bacterium known for its ability to convert cholesterol to coprostanol, a non-absorbable stanol, via a recently characterized metalloenzyme pathway (IsmB). Researchers have proposed this conversion pathway as a mechanism potentially relevant to cholesterol absorption in the colon, and observational and Mendelian randomization studies have examined the relative abundance of this organism in the gut microbiome in relation to lipid metabolism and cardiometabolic markers. However, the evidence linking E. coprostanoligenes to specific health outcomes is observational and population-level; strain-specific controlled trials in humans have not been conducted. The cholesterol-to-coprostanol conversion pathway represents a biologically plausible mechanism of interest, but causal efficacy in people has not been established for this strain. These are research topics, not findings; the papers do not establish that this strain treats or prevents any condition.
Where it's been studied Tags come from a conservative keyword scan of each paper's title, abstract, and summary. A tag is research coverage, not measured effect. How we classify this →
Share of this strain's 81 body-system-tagged papers that concern each system. Research coverage, not measured effect.
+3 more systems
Symptoms in the research A tag means the paper's text names the symptom or condition — research coverage, not evidence of benefit. How we classify this →
Share of this strain's 29 symptom-tagged papers that mention each symptom or condition. Research coverage, not evidence of benefit.
Research Study-type filters use AI-classified labels, audited but not guaranteed — check the paper itself before leaning on one. How we classify this →
228 papers reference this strain in the probiotic database.
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Citations
Selected papers that name this strain.
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[1]
PMID 41980965 →SpiR is a gut microbial enzyme that drives cholesterol conversion· Nature Communications · 2026
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[2]
Source →Discovery of the metalloenzyme IsmB revises a pathway for coprostanol formation by the human gut microbiome· bioRxiv (Cold Spring Harbor Laboratory) · 2025
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[3]
PMID 38572095 →Eubacterium coprostanoligenes alleviates chemotherapy-induced intestinal mucositis by enhancing intestinal mucus barrier· Acta Pharmaceutica Sinica B · 2023
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[4]
PMID 8123557 →Characterization of Eubacterium coprostanoligenes sp. nov., a Cholesterol-Reducing Anaerobe· International Journal of Systematic Bacteriology · 1994