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Faecalibacterium prausnitzii A2-165

◔ Human-origin
Sequenced
Public genome assembly available

Faecalibacterium prausnitzii A2-165 is a research reference strain of one of the most abundant and scientifically studied commensal bacteria in the healthy human gut. In vitro studies have examined this strain's butyrate production (a short-chain fatty acid that fuels intestinal lining cells), metabolite production, and interleukin-10 signaling pathways in immune cells. Animal model studies have examined this strain in models of gut inflammation. F. prausnitzii is not currently available as a commercial probiotic supplement — it is an obligate anaerobe that is highly oxygen-sensitive and technically challenging to formulate — so it is primarily a subject of basic and translational research rather than a product-ready strain. These are research topics, not findings; the papers do not establish that this strain treats or prevents any condition.

Where it's been studied

Share of this strain's 53 body-system-tagged papers that concern each system. Research coverage, not measured effect.

+1 more systems

Symptoms in the research

Share of this strain's 24 symptom-tagged papers that mention each symptom or condition. Research coverage, not evidence of benefit.

Research

60 papers reference this strain in the probiotic database.

Match confidence
2026 IN_VITRO
Cobalamin-mediated protection of Faecalibacterium duncaniae against oxidative stress: Insights from proteomic and membrane fatty acid profiles
· Microbiological Research
2026 IN_VITRO
Insights into the proteome of next-generation probiotic Faecalibacterium duncaniae A2-165 through label-free proteomics approach
· BMC Microbiology
2025 ANIMAL
The Secreted Metabolite Isopentenyladenine from Faecalibacterium prausnitzii Is Anti-inflammatory with Barrier-Protective Properties
· ACS Infectious Diseases
2025 ANIMAL
The Secreted Metabolite Isopentenyladenine from Faecalibacterium prausnitzii Mitigates Gut Inflammation
· bioRxiv (Cold Spring Harbor Laboratory)
2025 ANIMAL
Recombinant MAM from Faecalibacterium duncaniae exhibits a protective effect in DNBS-induced colitis
· Microbial Cell Factories
2024 IN_VITRO
Faecalibacterium prausnitzii A2-165 metabolizes host- and media-derived chemicals and induces transcriptional changes in colonic epithelium in GuMI human gut microphysiological system
· Microbiome Research Reports
2024 IN_VITRO
Structural Insights and Catalytic Mechanism of 3-Hydroxybutyryl-CoA Dehydrogenase from Faecalibacterium Prausnitzii A2-165
· International Journal of Molecular Sciences
2024 IN_VITRO
Faecalibacterium duncaniae A2-165 regulates the expression of butyrate synthesis, ferrous iron uptake, and stress-response genes based on acetate consumption
· Scientific Reports
2024 ANIMAL
Faecalibacterium duncaniae as a novel next generation probiotic against influenza
· Frontiers in Immunology
2022 OTHER
Genome-based, phenotypic and chemotaxonomic classification of Faecalibacterium strains: proposal of three novel species Faecalibacterium duncaniae sp. nov., Faecalibacterium hattorii sp. nov. and Faecalibacterium gallinarum sp. nov.
· INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY
2020 WGS
A comparative analysis of the genus Faecalibacterium and the utilisation of an enrichment based strategy for the isolation of gut phage
· Cork Open Research Archive (University College Cork, Ireland)
2020 ANIMAL
Prophylactic Faecalibacterium prausnitzii treatment prevents the acute breakdown of colonic epithelial barrier in a preclinical model of pelvic radiation disease
· Gut Microbes
2019 IN_VITRO
P837 The common food additives sodium sulfite and polysorbate 80 have a profound inhibitory effect on the commensal, anti-inflammatory bacterium Faecalibacterium prausnitzii: the ENIGMA study
· Journal of Crohn s and Colitis
2018 ANIMAL
Impact des phages tempérés sur la stabilité du microbiote intestinal : la lysogénie n'est pas un long fleuve tranquille
· theses.fr (ABES)
2018 ANIMAL
Impact of temperate phages on the stability of the gut microbiota : lysogeny is not a long quiet river
· theses.fr (ABES)
2018 OBSERVATIONAL
Age and fecal microbial strain-specific differences in patients with spondyloarthritis
· Arthritis Research & Therapy
2016 ANIMAL
Anti-nociceptive effect of Faecalibacterium prausnitzii in non-inflammatory IBS-like models
· Scientific Reports
2016 ANIMAL
Analyse des mécanismes impliqués dans les effets bénéfiques de la bactérie probiotique Lactobacillus casei BL23
·
2016 IN_VITRO
Faecalibacterium prausnitzii A2-165 has a high capacity to induce IL-10 in human and murine dendritic cells and modulates T cell responses
· Scientific Reports
2015 ANIMAL
Identification of Metabolic Signatures Linked to Anti-Inflammatory Effects of Faecalibacterium prausnitzii
· mBio
Browse all 60 papers →

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Citations

Selected papers that name this strain.

  1. [1]
    The Secreted Metabolite Isopentenyladenine from Faecalibacterium prausnitzii Mitigates Gut Inflammation
    · bioRxiv (Cold Spring Harbor Laboratory) · 2025
    Source →
  2. [2]
    Faecalibacterium prausnitzii A2-165 has a high capacity to induce IL-10 in human and murine dendritic cells and modulates T cell responses
    · Scientific Reports · 2016
    PMID 26725514 →
  3. [3]
    Interactions of commensal bacteria with the host immune system
    · · 2013
    Source →