Strain Profile
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Lacticaseibacillus paracasei KW3110
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Food-origin
Where this strain was first isolated, curated from the literature and culture-collection catalogs. It describes provenance only — not suitability, and not benefit.
How we classify this →
Sequenced
Whether a public genome assembly is linked for this strain. Without one the genome screens cannot run. It is not a verdict on the organism.
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Public genome assembly available
Lacticaseibacillus paracasei KW3110 is a lactic acid bacterium studied in the context of immune regulation and inflammatory processes. Research includes randomized controlled trials in humans examining seasonal allergic rhinitis symptoms and ocular disorders, as well as in vitro studies on immune cell signaling and toll-like receptor activation. Animal studies have investigated mechanisms including IL-12 production, retinal inflammation, and age-related cellular changes. Both heat-killed and viable formulations have been studied in human and preclinical models. These are research topics, not findings; the papers do not establish that this strain treats or prevents any condition.
Where it's been studied Tags come from a conservative keyword scan of each paper's title, abstract, and summary. A tag is research coverage, not measured effect. How we classify this →
Share of this strain's 21 body-system-tagged papers that concern each system. Research coverage, not measured effect.
Symptoms in the research A tag means the paper's text names the symptom or condition — research coverage, not evidence of benefit. How we classify this →
Share of this strain's 6 symptom-tagged papers that mention each symptom or condition. Research coverage, not evidence of benefit.
Research Study-type filters use AI-classified labels, audited but not guaranteed — check the paper itself before leaning on one. How we classify this →
22 papers reference this strain in the probiotic database.
Match confidence
How strongly this paper was matched to this strain when the corpus was linked. It orders the list — it says nothing about the study's quality or its findings.
How we classify this →
2026
IN_VITRO
2026
IN_VITRO
2025
RCT
2025
RCT
2022
IN_VITRO
2021
IN_VITRO
2021
ANIMAL
2020
IN_VITRO
2020
RCT
2018
ANIMAL
2018
ANIMAL
2018
RCT
2012
IN_VITRO
2009
ANIMAL
2009
RCT
2008
OBSERVATIONAL
2007
ANIMAL
2007
IN_VITRO
2005
RCT
2004
ANIMAL
Browse all 22 papers →
Toll-Like Receptor 8-Mediated Interleukin-12 Production in Human Dendritic Cells Triggered by RNA of Lacticaseibacillus paracasei KW3110
· International Archives of Allergy and Immunology
Supplementary Material for: Toll-like receptor 8-mediated Interleukin-12 production in human dendritic cells triggered by RNA of Lacticaseibacillus paracasei KW3110
· Figshare
Table 1_Effect of heat-killed Lacticaseibacillus paracasei KW3110 on mild to moderate seasonal allergic rhinitis symptoms in Japanese adults: a randomized, double-blind, placebo-controlled parallel-group study.docx
· Figshare
Effect of heat-killed Lacticaseibacillus paracasei KW3110 on mild to moderate seasonal allergic rhinitis symptoms in Japanese adults: a randomized, double-blind, placebo-controlled parallel-group study
· Frontiers in Nutrition
Lactobacillus paracasei KW3110 Prevents Inflammatory-Stress-Induced Mitochondrial Dysfunction in Mouse Macrophages
· International Journal of Molecular Sciences
Dectin-2 mediates phagocytosis of Lactobacillus paracasei KW3110 and IL-10 production by macrophages
· Scientific Reports
Long-term intake of Lactobacillus paracasei KW3110 prevents age-related circadian locomotor activity and changes in gut metabolism in physiologically aged mice
· Experimental Gerontology
Lactic acid bacterium, Lactobacillus paracasei KW3110, suppresses inflammatory stress-induced caspase-1 activation by promoting interleukin-10 production in mouse and human immune cells
· PLoS ONE
Lactobacillus paracasei KW3110 Suppresses Inflammatory Stress-Induced Premature Cellular Senescence of Human Retinal Pigment Epithelium Cells and Reduces Ocular Disorders in Healthy Humans
· International Journal of Molecular Sciences
Lactobacillus paracasei KW3110 Prevents Blue Light-Induced Inflammation and Degeneration in the Retina
· Nutrients
Long-term intake of Lactobacillus paracasei KW3110 prevents age-related chronic inflammation and retinal cell loss in physiologically aged mice
· Aging
Effect of Heat-Killed Lactobacillus paracasei KW3110 Ingestion on Ocular Disorders Caused by Visual Display Terminal (VDT) Loads: A Randomized, Double-Blind, Placebo-Controlled Parallel-Group Study
· Nutrients
MyD88 Associated ROS Generation Is Crucial for Lactobacillus Induced IL-12 Production in Macrophage
· PLoS ONE
Orally Administered Lactobacillus paracasei KW3110 Induces in Vivo IL-12 Production
· Bioscience Biotechnology and Biochemistry
Effects of daily intake of Lactobacillus paracasei strain KW3110 on Japanese cedar pollinosis
· Allergy and Asthma Proceedings
Evaluation of the probiotic potential of Lactobacillus paracasei KW3110 based on in vitro tests and oral administration tests in healthy adults
· The Journal of General and Applied Microbiology
Dietary Supplementation with Lactic Acid Bacteria Attenuates the Development of Atopic Dermatitis-Like Skin Lesions in NC/Nga Mice in a Strain-Dependent Manner
· International Archives of Allergy and Immunology
MyD88 but Not TLR2, 4 or 9 Is Essential for IL-12 Induction by Lactic Acid Bacteria
· Bioscience Biotechnology and Biochemistry
A Double-blind Trial of Lactobacillus paracasei Strain KW3110 Administration for Immunomodulation in Patients with Pollen Allergy
· Allergology International
The Anti-Allergic Effects of Lactic Acid Bacteria Are Strain Dependent and Mediated by Effects on both Th1/Th2 Cytokine Expression and Balance
· International Archives of Allergy and Immunology
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Citations
Selected papers that name this strain.
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[1]
Source →Table 1_Effect of heat-killed Lacticaseibacillus paracasei KW3110 on mild to moderate seasonal allergic rhinitis symptoms in Japanese adults: a randomized, double-blind, placebo-controlled parallel-group study.docx· Figshare · 2025
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[2]
PMID 32708511 →Lactobacillus paracasei KW3110 Suppresses Inflammatory Stress-Induced Premature Cellular Senescence of Human Retinal Pigment Epithelium Cells and Reduces Ocular Disorders in Healthy Humans· International Journal of Molecular Sciences · 2020