Strain Profile
· NCBI Strain Taxon
1408186
NCBI Taxonomy's node for this specific strain. A different identifier from the culture-collection deposit numbers below, which name a physical stock rather than a taxonomic node.
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Lactobacillus johnsonii N6.2
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Food-origin
Where this strain was first isolated, curated from the literature and culture-collection catalogs. It describes provenance only — not suitability, and not benefit.
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Sequenced
Whether a public genome assembly is linked for this strain. Without one the genome screens cannot run. It is not a verdict on the organism.
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Public genome assembly available
Lactobacillus johnsonii N6.2 has a moderately developed clinical evidence base, anchored by multiple double-blind, randomized human trials evaluating safety, tolerability, and host immune responses in healthy adults. These trials have examined immune function and specific immune cell populations. In vitro research has examined the strain's extracellular vesicles, including activity in relation to murine norovirus, immunomodulatory phospholipid interactions with dendritic cells, and pancreatic cell signaling; these remain preliminary and unconfirmed in human trials. Animal model work has explored gut flora-related autoimmunity research in an early-stage context. These are research topics, not findings; the papers do not establish that this strain treats or prevents any condition.
Where it's been studied Tags come from a conservative keyword scan of each paper's title, abstract, and summary. A tag is research coverage, not measured effect. How we classify this →
Share of this strain's 20 body-system-tagged papers that concern each system. Research coverage, not measured effect.
Symptoms in the research A tag means the paper's text names the symptom or condition — research coverage, not evidence of benefit. How we classify this →
Share of this strain's 5 symptom-tagged papers that mention each symptom or condition. Research coverage, not evidence of benefit.
Research Study-type filters use AI-classified labels, audited but not guaranteed — check the paper itself before leaning on one. How we classify this →
25 papers reference this strain in the probiotic database.
Match confidence
How strongly this paper was matched to this strain when the corpus was linked. It orders the list — it says nothing about the study's quality or its findings.
How we classify this →
2025
IN_VITRO
2025
ANIMAL
2024
IN_VITRO
2023
IN_VITRO
2023
OBSERVATIONAL
2023
IN_VITRO
2022
IN_VITRO
2021
IN_VITRO
2020
IN_VITRO
2019
IN_VITRO
2018
ANIMAL
2018
ANIMAL
2017
RCT
2017
RCT
2016
RCT
2016
REVIEW
2015
ANIMAL
2015
IN_VITRO
2013
ANIMAL
2011
IN_VITRO
Browse all 25 papers →
Lactobacillus johnsonii N6.2 Phospholipids Induce T Cell Anergy upon Cognate Dendritic Cell Interactions
· Metabolites
Lactobacillus johnsonii N6.2 improves glycemia and reduces diabetes-induced organ injury in the db/db mice model
· Journal of Endocrinology
The Sdp-SH3b2 domain contained in Lactobacillus johnsonii N6.2-derived extracellular vesicles inhibit murine norovirus replication
· Frontiers in Immunology
Internalization of extracellular vesicles from Lactobacillus johnsonii N6.2 elicit an RNA sensory response in human pancreatic cell lines
· Journal of Extracellular Biology
Identification of food and nutrient components as predictors of Lactobacillus colonization
· Frontiers in Nutrition
Lactobacillus johnsonii N6.2 phospholipids induce immature-like dendritic cells with a migratory-regulatory-like transcriptional signature
· Gut Microbes
Nanovesicles From Lactobacillus johnsonii N6.2 Reduce Apoptosis in Human Beta Cells by Promoting AHR Translocation and IL10 Secretion
· Frontiers in Immunology
Identification of Biomarkers for Systemic Distribution of Nanovesicles From Lactobacillus johnsonii N6.2
· Frontiers in Immunology
Maturation of dendritic cells derived from type 1 diabetes-susceptible NOD mice is differentially regulated by two strains of generally regarded as safe (GRAS) Lactobacillus
· The Journal of Immunology
Blueberries as an additive to increase the survival of Lactobacillus johnsonii N6.2 to lyophilisation
· Beneficial Microbes
Sex Modulates Lactobacillus johnsonii N6.2 and Phytophenol Effectiveness in Reducing High Fat Diet Induced mTOR Activation in Sprague-Dawley Rats
· Frontiers in Microbiology
Lactobacillus johnsonii N6.2 diminishes caspase-1 maturation in the gastrointestinal system of diabetes prone rats
· Beneficial Microbes
Immunological effects of Lactobacillus johnsonii N6.2 in healthy adults: A double‐blind, randomized trial
· The FASEB Journal
Lactobacillus johnsonii N6.2 Modulates the Host Immune Responses: A Double-Blind, Randomized Trial in Healthy Adults
· Frontiers in Immunology
A Double‐Blind, Randomized Human Trial To Evaluate The Safety, Tolerability, And Host Response To Lactobacillus johnsonii N6.2
· The FASEB Journal
The Synergistic Contribution of Lactobacillus and Dietary Phytophenols in Host Health
· InTech eBooks
Gut bacteria modulation of antigen presenting cells in a mouse model of autoimmune diabetes. (THER5P.915)
· The Journal of Immunology
H2O2 production rate in Lactobacillus johnsonii is modulated via the interplay of a heterodimeric flavin oxidoreductase with a soluble 28 Kd PAS domain containing protein
· Frontiers in Microbiology
Use of gut flora as a natural vaccine against autoimmunity
· Journal of Clinical & Cellular Immunology
An Inserted α/β Subdomain Shapes the Catalytic Pocket of Lactobacillus johnsonii Cinnamoyl Esterase
· PLoS ONE
Discussion
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Citations
Selected papers that name this strain.
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[1]
PMID 28659913 →Lactobacillus johnsonii N6.2 Modulates the Host Immune Responses: A Double-Blind, Randomized Trial in Healthy Adults· Frontiers in Immunology · 2017
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[2]
Source →Immunological effects of Lactobacillus johnsonii N6.2 in healthy adults: A double‐blind, randomized trial· The FASEB Journal · 2017
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[3]
Source →A Double‐Blind, Randomized Human Trial To Evaluate The Safety, Tolerability, And Host Response To Lactobacillus johnsonii N6.2· The FASEB Journal · 2016