Strain Profile
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Lactobacillus johnsonii La1
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Food-origin
Where this strain was first isolated, curated from the literature and culture-collection catalogs. It describes provenance only — not suitability, and not benefit.
How we classify this →
Sequenced
Whether a public genome assembly is linked for this strain. Without one the genome screens cannot run. It is not a verdict on the organism.
How we classify this →
Public genome assembly available
Lactobacillus johnsonii La1 (also known as NCC533) is among the more extensively studied probiotic strains, with human randomized controlled trials examining several applications. Multiple RCTs have investigated its role in relation to Helicobacter pylori colonization, and separate clinical trials have examined postoperative Crohn's disease prophylaxis. In vitro and animal work has examined antimicrobial activity against Giardia intestinalis in laboratory settings, involving bile salt hydrolases. La1 has also been studied in infant formula contexts in relation to fecal microbiota composition, and in a trial in elderly hospitalized patients examining nutritional and immune status. These are research topics, not findings; the papers do not establish that this strain treats or prevents any condition.
Where it's been studied Tags come from a conservative keyword scan of each paper's title, abstract, and summary. A tag is research coverage, not measured effect. How we classify this →
Share of this strain's 52 body-system-tagged papers that concern each system. Research coverage, not measured effect.
+2 more systems
Symptoms in the research A tag means the paper's text names the symptom or condition — research coverage, not evidence of benefit. How we classify this →
Share of this strain's 23 symptom-tagged papers that mention each symptom or condition. Research coverage, not evidence of benefit.
Research Study-type filters use AI-classified labels, audited but not guaranteed — check the paper itself before leaning on one. How we classify this →
83 papers reference this strain in the probiotic database.
Match confidence
How strongly this paper was matched to this strain when the corpus was linked. It orders the list — it says nothing about the study's quality or its findings.
How we classify this →
2018
ANIMAL
2016
ANIMAL
2016
ANIMAL
2016
IN_VITRO
2012
IN_VITRO
2012
ANIMAL
2010
RCT
2008
RCT
2008
RCT
2007
RCT
2007
RCT
2007
REVIEW
2006
RCT
2006
RCT
2006
RCT
2006
RCT
2005
RCT
2005
ANIMAL
2005
ANIMAL
2005
IN_VITRO
Browse all 83 papers →
Bile-Salt-Hydrolases from the Probiotic Strain Lactobacillus johnsonii La1 Mediate Anti-giardial Activity in Vitro and in Vivo
· Frontiers in Microbiology
Role of Bile-Salts Hydrolases (BSH) of probiotic lactobacilli against giardiasis
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Rôle des Bile Salt Hydrolases (BSH) des lactobacilles probiotiques dans le contrôle de la giardiose
· theses.fr (ABES)
Deconjugated Bile Salts Produced by Extracellular Bile-Salt Hydrolase-Like Activities from the Probiotic Lactobacillus johnsonii La1 Inhibit Giardia duodenalis In vitro Growth
· Frontiers in Microbiology
Improved Bioavailability of Dietary Phenolic Acids in Whole Grain Barley and Oat Groat following Fermentation with Probiotic Lactobacillus acidophilus, Lactobacillus johnsonii, and Lactobacillus reuteri
· Journal of Agricultural and Food Chemistry
Reduction of Overall Helicobacter pylori Colonization Levels in the Stomach of Mongolian Gerbil by Lactobacillus johnsonii La1 (LC1) and Its in Vitro Activities against H. pylori Motility and Adherence
· Bioscience Biotechnology and Biochemistry
A randomized double-blind trial on perioperative administration of probiotics in colorectal cancer patients
· World Journal of Gastroenterology
Urinary D-Lactate Excretion in Infants Receiving Lactobacillus johnsonii with Formula
· Annals of Nutrition and Metabolism
Modulation of Helicobacter pylori colonization with cranberry juice and Lactobacillus johnsonii La1 in children
· Nutrition
Ineffectiveness of Lactobacillus johnsonii LA1 for prophylaxis of postoperative recurrence in Crohn's disease: a randomised, double blind, placebo controlled GETAID trial
· Yearbook of Gastroenterology
Improvement of nutritional status and incidence of infection in hospitalised, enterally fed elderly by feeding of fermented milk containing probiotic Lactobacillus johnsonii La1 (NCC533)
· British Journal Of Nutrition
Probiotics and Natural Defense Function of the Host
· Bioscience and Microflora
Improvement of the human intestinal flora by ingestion of the probiotic strain Lactobacillus johnsonii La1
· British Journal Of Nutrition
Effects of probiotic or prebiotic supplemented milk formulas on fecal microbiota composition of infants.
· PubMed
Multicenter randomized-controlled clinical trial of probiotics (Lactobacillus johnsonii, LA1) on early endoscopic recurrence of Crohnʼs disease after ileo-caecal resection
· Inflammatory Bowel Diseases
Inefficacité du Lactobacillus johnsonii LA1 dans la prophylaxie des récidives postopératoires de la maladie de Crohn un essai GETAID contrôlé, randomisé, en double aveugle versus placebo
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Ineffectiveness of Lactobacillus johnsonii LA1 for prophylaxis of postoperative recurrence in Crohn’s disease: a randomised, double blind, placebo controlled GETAID trial
· Gut
Lactobacillus johnsonii La1 Antagonizes Giardia intestinalis In Vivo
· Infection and Immunity
Lactobacillus johnsonii La1 Attenuates Helicobacter pylori-Associated Gastritis and Reduces Levels of Proinflammatory Chemokines in C57BL/6 Mice
· Clinical and Vaccine Immunology
GroEL of Lactobacillus johnsonii La1 (NCC 533) Is Cell Surface Associated: Potential Role in Interactions with the Host and the Gastric Pathogen Helicobacter pylori
· Infection and Immunity
Discussion
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Citations
Selected papers that name this strain.
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[1]
PMID 20066735 →A randomized double-blind trial on perioperative administration of probiotics in colorectal cancer patients· World Journal of Gastroenterology · 2010
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[2]
Source →Probiotics and Natural Defense Function of the Host· Bioscience and Microflora · 2007
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[3]
PMID 17617944 →Improvement of nutritional status and incidence of infection in hospitalised, enterally fed elderly by feeding of fermented milk containing probiotic Lactobacillus johnsonii La1 (NCC533)· British Journal Of Nutrition · 2007
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[4]
PMID 16469146 →Improvement of the human intestinal flora by ingestion of the probiotic strain Lactobacillus johnsonii La1· British Journal Of Nutrition · 2006
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[5]
PMID 16837430 →Effects of probiotic or prebiotic supplemented milk formulas on fecal microbiota composition of infants.· PubMed · 2006
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[6]
Source →El CONSUMO REGULAR DE LACTOBACILLUS JOHNSONII LA1 INTERFIERE CON LA COLONIZACIÓN GÁSTRICA POR HELICOBACTER PYLORI· Revista chilena de nutrición · 2003
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[7]
PMID 11204805 →Favourable effect of an acidified milk (LC-1) on Helicobacter pylori gastritis in man· European Journal of Gastroenterology & Hepatology · 2001
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[8]
PMID 10342225 →Modulation of Nonspecific Mechanisms of Defense by Lactic Acid Bacteria: Effective Dose· Journal of Dairy Science · 1999