Strain Profile
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Lactococcus lactis NCDO 2118
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Food-origin
Where this strain was first isolated, curated from the literature and culture-collection catalogs. It describes provenance only — not suitability, and not benefit.
How we classify this →
Sequenced
Whether a public genome assembly is linked for this strain. Without one the genome screens cannot run. It is not a verdict on the organism.
How we classify this →
Public genome assembly available
Lactococcus lactis NCDO 2118 is a research-stage strain notable for its capacity to produce gamma-aminobutyric acid (GABA), a neuroactive compound, and for its characterization in genomic studies. Animal studies have examined this strain in colitis models, blood pressure regulation in hypertensive rats, and alcohol preference behavior, in relation to its GABA production. All available evidence is in vitro or animal-based; no human clinical trials have been published for this strain. These are research topics, not findings; the papers do not establish that this strain treats or prevents any condition.
Where it's been studied Tags come from a conservative keyword scan of each paper's title, abstract, and summary. A tag is research coverage, not measured effect. How we classify this →
Share of this strain's 21 body-system-tagged papers that concern each system. Research coverage, not measured effect.
Symptoms in the research A tag means the paper's text names the symptom or condition — research coverage, not evidence of benefit. How we classify this →
Share of this strain's 14 symptom-tagged papers that mention each symptom or condition. Research coverage, not evidence of benefit.
Research Study-type filters use AI-classified labels, audited but not guaranteed — check the paper itself before leaning on one. How we classify this →
43 papers reference this strain in the probiotic database.
Match confidence
How strongly this paper was matched to this strain when the corpus was linked. It orders the list — it says nothing about the study's quality or its findings.
How we classify this →
2026
ANIMAL
2026
ANIMAL
2024
ANIMAL
2021
ANIMAL
2021
ANIMAL
2021
ANIMAL
2021
ANIMAL
2021
ANIMAL
2021
IN_VITRO
2021
ANIMAL
2021
ANIMAL
2020
ANIMAL
2019
WGS
2019
IN_VITRO
2018
IN_VITRO
2017
REVIEW
2017
WGS
2016
IN_VITRO
2016
ANIMAL
2016
ANIMAL
Browse all 43 papers →
Immunomodulatory Effects of Lactococcus lactis on the Gut—Pancreas Axis 2257747
· The Journal of Immunology
Effects of Lacticaseibacillus rhamnosus L156.4 and Lactococcus lactis NCDO 2118 strains on reducing alcohol intake and preference in an animal model of high alcohol consumption and preference
· Scientific Reports
Efeitos atenuantes de um blend probiótico no comportamento de preferência pelo etanol em modelo animal
· LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)
Efeitos da expressão heteróloga da proteína SlpB de Propionibacterium freudenreichii CIRM-BIA 129 em Lactococcus lactis NCDO2118 e suas propriedades probióticas aplicadas em modelo murino de colite induzida por DSS
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SlpB Protein Enhances the Probiotic Potential of L. lactis NCDO 2118 in Colitis Mice Model
· Frontiers in Pharmacology
Image2_SlpB Protein Enhances the Probiotic Potential of L. lactis NCDO 2118 in Colitis Mice Model.tif
· Figshare
Image4_SlpB Protein Enhances the Probiotic Potential of L. lactis NCDO 2118 in Colitis Mice Model.tif
· Figshare
Therapeutic Effects of Probiotic Minas Frescal Cheese on the Attenuation of Ulcerative Colitis in a Murine Model
· Frontiers in Microbiology
Environmental Conditions Affecting GABA Production in Lactococcus lactis NCDO 2118
· Microorganisms
Image1_SlpB Protein Enhances the Probiotic Potential of L. lactis NCDO 2118 in Colitis Mice Model.tif
· Figshare
Image3_SlpB Protein Enhances the Probiotic Potential of L. lactis NCDO 2118 in Colitis Mice Model.tif
· Figshare
Hsp65-Producing Lactococcocus lactis Prevents Antigen-Induced Arthritis in Mice
· Frontiers in Immunology
Análises ômicas de duas bactérias potencialmente probióticas revelam novas bacteriocinas de Lactobacillus rhamnosus L156.4 e proteínas com potencial imunomodulador de Lactococcus lactis NCDO 2118
· Americanae (AECID Library)
Quantitative Proteomic Analysis of the Response of Probiotic Putative Lactococcus lactis NCDO 2118 Strain to Different Oxygen Availability Under Temperature Variation
· Frontiers in Microbiology
Comparative proteomic analysis of four biotechnological strains Lactococcus lactis through label‐free quantitative proteomics
· Microbial Biotechnology
Novel Biotechnological and Therapeutic Applications for Wild Type and Genetically Engineered Lactic Acid Bacteria
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Analyses of the probiotic property and stress resistance-related genes of Lactococcus lactis subsp. lactis NCDO 2118 through comparative genomics and in vitro assays
· PLoS ONE
GABA Production in Lactococcus lactis Is Enhanced by Arginine and Co-addition of Malate
· Frontiers in Microbiology
Oral administration of Lactococcus lactis expressing recombinant 15-lipoxygenase-1 (15 LOX-1) modulates chemically induced colitis in mice
· Medical Research Archives
Lactococcus lactis NCDO2118 produces anti-hypertensive GABA and exerts acute hypotensive in spontaneously hypertensive rats
· Medical Research Archives
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Citations
Selected papers that name this strain.
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[1]
Source →Immunomodulatory Effects of Lactococcus lactis on the Gut—Pancreas Axis 2257747· The Journal of Immunology · 2026
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[2]
PMID 25110521 →Anti-inflammatory effects of Lactococcus lactis NCDO 2118 during the remission period of chemically induced colitis· Gut Pathogens · 2014
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[3]
PMID 25278529 →Genome Sequence of Lactococcus lactis subsp. lactis NCDO 2118, a GABA-Producing Strain· Genome Announcements · 2014
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[4]
Source →Análise do potencial probiótico de Lactococcus lactis subsp. lactis NCDO 2118 por meio de genômica comparativa· Americanae (AECID Library) · 2014