Strain Profile
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Lactococcus lactis MG1363
DEP
MG1363
◐
Food-origin
Where this strain was first isolated, curated from the literature and culture-collection catalogs. It describes provenance only — not suitability, and not benefit.
How we classify this →
Sequenced
Whether a public genome assembly is linked for this strain. Without one the genome screens cannot run. It is not a verdict on the organism.
How we classify this →
Public genome assembly available
Lactococcus lactis MG1363 is a widely used laboratory model strain for studying lactic acid bacterial genetics, stress responses, and metabolic pathways. The indexed literature reflects its role as a research tool rather than a consumer probiotic: studies cover acid tolerance, polysaccharide production, bacteriophage interactions, and expression system development. While L. lactis species are used in food fermentation and have been explored in recombinant protein delivery contexts, MG1363 is primarily a reference strain and its direct relevance to human health outcomes has not been characterized in clinical trials within the indexed literature.
Where it's been studied Tags come from a conservative keyword scan of each paper's title, abstract, and summary. A tag is research coverage, not measured effect. How we classify this →
Share of this strain's 56 body-system-tagged papers that concern each system. Research coverage, not measured effect.
+4 more systems
Symptoms in the research A tag means the paper's text names the symptom or condition — research coverage, not evidence of benefit. How we classify this →
Share of this strain's 14 symptom-tagged papers that mention each symptom or condition. Research coverage, not evidence of benefit.
+1 more symptoms
Research Study-type filters use AI-classified labels, audited but not guaranteed — check the paper itself before leaning on one. How we classify this →
287 papers reference this strain in the probiotic database.
Match confidence
How strongly this paper was matched to this strain when the corpus was linked. It orders the list — it says nothing about the study's quality or its findings.
How we classify this →
2025
IN_VITRO
2025
ANIMAL
2024
IN_VITRO
2022
ANIMAL
2021
ANIMAL
2020
ANIMAL
2020
IN_VITRO
2020
ANIMAL
2018
ANIMAL
2017
ANIMAL
2016
ANIMAL
2016
ANIMAL
2014
ANIMAL
2013
ANIMAL
2012
ANIMAL
2012
ANIMAL
2012
ANIMAL
2012
ANIMAL
2012
ANIMAL
2009
ANIMAL
Browse all 287 papers →
Precision Antimicrobial Therapy Against Fusobacterium nucleatum Using Bioengineered Probiotics Expressing Guided Antimicrobial Peptides (gAMPs)
· Microbial Biotechnology
The engineered probiotic strain Lactococcus lactis MG1363-pMG36e-GLP-1 regulates microglial polarization and gut dysbiosis in a transgenic mouse model of Parkinson’s disease
· Neural Regeneration Research
Targeted therapy of oncomicrobe F. nucleatum with bioengineered probiotic expressing guided antimicrobial peptide (gAMP)
· bioRxiv (Cold Spring Harbor Laboratory)
Neurotrophic Role of the Next-Generation Probiotic Strain L. lactis MG1363-pMG36e-GLP-1 on Parkinson’s Disease via Inhibiting Ferroptosis
· Nutrients
Recombinant Lactococcus lactis Carrying IL-4 and IL-10 Coding Vectors Protects against Type 1 Diabetes in NOD Mice and Attenuates Insulitis in the STZ-Induced Model
· Journal of Diabetes Research
Attenuation of intestinal inflammation in IL-10 deficient mice by a plasmid carrying Lactococcus lactis strain
· BMC Biotechnology
Quantifying and Engineering Mucus Adhesion of Probiotics
· ACS Synthetic Biology
Therapeutic effect of GLP-1 engineered strain on mice model of Alzheimer’s disease and Parkinson’s disease
· AMB Express
Microencapsulation of Lactic Acid Bacteria Improves the Gastrointestinal Delivery and in situ Expression of Recombinant Fluorescent Protein
· Frontiers in Microbiology
Ectopic expression of innate immune protein Lipocalin-2 in probiotic Lactococcus lactis protects against environmental and gut inflammatory stressors
· The Journal of Immunology
Evaluation of the biosafety of recombinant lactic acid bacteria designed to prevent and treat colitis
· Journal of Medical Microbiology
Lactococcus lactis carrying the pValac eukaryotic expression vector coding for IL-4 reduces chemically-induced intestinal inflammation by increasing the levels of IL-10-producing regulatory cells
· Microbial Cell Factories
Lactococcus lactiscarrying the pValac DNA expression vector coding for IL-10 reduces inflammation in a murine model of experimental colitis
· BMC Biotechnology
Probiotics Can Generate FoxP3 T-Cell Responses in the Small Intestine and Simultaneously Inducing CD4 and CD8 T Cell Activation in the Large Intestine
· PLoS ONE
Bioluminescence Imaging Study of Spatial and Temporal Persistence of Lactobacillus plantarum and Lactococcus lactis in Living Mice
· Applied and Environmental Microbiology
L. plantarum, L. salivarius, and L. lactis Attenuate Th2 Responses and Increase Treg Frequencies in Healthy Mice in a Strain Dependent Manner
· PLoS ONE
In vivo imaging of Escherichia coli and Lactococcus lactis in murine intestines using a reporter luciferase gene
· Food Science and Biotechnology
Lactococcus lactis expressing food-grade β-galactosidase alleviates lactose intolerance symptoms in post-weaning Balb/c mice
· Applied Microbiology and Biotechnology
Oral Immunization with Recombinant Lactococcus lactis Expressing the Hemagglutinin of the Avian Influenza Virus Induces Mucosal and Systemic Immune Responses
· Future Microbiology
Development of a Recombinant Ureolytic Lactococcus Lactis for Urea Removal
· Artificial Cells Blood Substitutes and Biotechnology
Discussion
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Citations
Selected papers that name this strain.
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[1]
PMID 40522767 →The engineered probiotic strain Lactococcus lactis MG1363-pMG36e-GLP-1 regulates microglial polarization and gut dysbiosis in a transgenic mouse model of Parkinson’s disease· Neural Regeneration Research · 2025
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[2]
PMID 36432569 →Neurotrophic Role of the Next-Generation Probiotic Strain L. lactis MG1363-pMG36e-GLP-1 on Parkinson’s Disease via Inhibiting Ferroptosis· Nutrients · 2022
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[3]
PMID 33604389 →Recombinant Lactococcus lactis Carrying IL-4 and IL-10 Coding Vectors Protects against Type 1 Diabetes in NOD Mice and Attenuates Insulitis in the STZ-Induced Model· Journal of Diabetes Research · 2021
-
[4]
PMID 32703192 →Attenuation of intestinal inflammation in IL-10 deficient mice by a plasmid carrying Lactococcus lactis strain· BMC Biotechnology · 2020
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[5]
PMID 32333225 →Therapeutic effect of GLP-1 engineered strain on mice model of Alzheimer’s disease and Parkinson’s disease· AMB Express · 2020
-
[6]
PMID 30344518 →Microencapsulation of Lactic Acid Bacteria Improves the Gastrointestinal Delivery and in situ Expression of Recombinant Fluorescent Protein· Frontiers in Microbiology · 2018
-
[7]
PMID 27576902 →Lactococcus lactis carrying the pValac eukaryotic expression vector coding for IL-4 reduces chemically-induced intestinal inflammation by increasing the levels of IL-10-producing regulatory cells· Microbial Cell Factories · 2016
-
[8]
PMID 27469354 →Evaluation of the biosafety of recombinant lactic acid bacteria designed to prevent and treat colitis· Journal of Medical Microbiology · 2016
-
[9]
PMID 25106058 →Lactococcus lactiscarrying the pValac DNA expression vector coding for IL-10 reduces inflammation in a murine model of experimental colitis· BMC Biotechnology · 2014
-
[10]
PMID 23861953 →Probiotics Can Generate FoxP3 T-Cell Responses in the Small Intestine and Simultaneously Inducing CD4 and CD8 T Cell Activation in the Large Intestine· PLoS ONE · 2013