Strain Profile
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Levilactobacillus brevis SBC8803
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Food-origin
Where this strain was first isolated, curated from the literature and culture-collection catalogs. It describes provenance only — not suitability, and not benefit.
How we classify this →
Sequenced
Whether a public genome assembly is linked for this strain. Without one the genome screens cannot run. It is not a verdict on the organism.
How we classify this →
Public genome assembly available
Levilactobacillus brevis SBC8803 (also marketed as SBL88) has an unusual research profile centered on heat-killed rather than live cells, a preparation sometimes called a paraprobiotic. It has been studied in animal models and in human trials, including a small human crossover pilot and one RCT, in relation to sleep quality, with proposed mechanisms involving serotonin-related pathways in the gut. Separate animal work has examined skin barrier function and dry skin markers in relation to this strain. The RCT examining sleep is single, industry-affiliated, and was conducted in a Japanese population. These are research topics, not findings; the papers do not establish that this strain treats or prevents any condition.
Where it's been studied Tags come from a conservative keyword scan of each paper's title, abstract, and summary. A tag is research coverage, not measured effect. How we classify this →
Share of this strain's 23 body-system-tagged papers that concern each system. Research coverage, not measured effect.
Symptoms in the research A tag means the paper's text names the symptom or condition — research coverage, not evidence of benefit. How we classify this →
Share of this strain's 10 symptom-tagged papers that mention each symptom or condition. Research coverage, not evidence of benefit.
Research Study-type filters use AI-classified labels, audited but not guaranteed — check the paper itself before leaning on one. How we classify this →
29 papers reference this strain in the probiotic database.
Match confidence
How strongly this paper was matched to this strain when the corpus was linked. It orders the list — it says nothing about the study's quality or its findings.
How we classify this →
2026
ANIMAL
2026
ANIMAL
2022
OTHER
2019
ANIMAL
2019
ANIMAL
2019
ANIMAL
2018
RCT
2018
RCT
2016
ANIMAL
2016
OBSERVATIONAL
2015
ANIMAL
2014
ANIMAL
2014
ANIMAL
2013
ANIMAL
2012
RCT
2011
ANIMAL
2011
ANIMAL
2008
ANIMAL
2019
ANIMAL
2014
ANIMAL
Browse all 29 papers →
Systems-level investigation of the anxiolytic gut–brain interactions induced by paraprobiotic Lactobacillus brevis SBC8803 in zebrafish
· Frontiers in Microbiology
Systems-level Investigation of the Anxiolytic Gut–Brain Interactions induced by Paraprobiotic Lactobacillus brevis SBC8803 in Zebrafish
· bioRxiv (Cold Spring Harbor Laboratory)
Probiotic polyphosphate improves the intestinal injury through the integrin mediated endocytic pathway
· Proceedings for Annual Meeting of The Japanese Pharmacological Society
Oral administration of heat-killed Lactobacillus brevis SBC8803 elevates the ratio of acyl/des-acyl ghrelin in blood and increases short-term food intake
· Beneficial Microbes
Dietary Heat-Killed Lactobacillus brevis SBC8803 Attenuates Chronic Sleep Disorders Induced by Psychophysiological Stress in Mice
· Journal of Nutritional Science and Vitaminology
Dietary heat‐killed Lactobacillus brevis SBC8803 (SBL88™) improves hippocampus‐dependent memory performance and adult hippocampal neurogenesis
· Neuropsychopharmacology Reports
Sleep Quality Improvement Effects of Lactobacillus brevis SBC8803 (SBL88 Lactic Acid Bacteria) Intake: A Randomized, Placebo-Controlled, Double-Blind, Parallel-Group Comparative Study
Lactobacillus brevis SBC8803（SBL88TM乳酸菌）摂取による睡眠の質改善効果―ランダム化プラセボ対照二重盲検並行群間比較試験―
· 薬理と治療
Sleep Quality Improvement Effects of Lactobacillus brevis SBC8803 (SBL88 Lactic Acid Bacteria) Intake: A Randomized, Placebo-Controlled, Double-Blind, Parallel-Group Comparative Study
Lactobacillus brevis SBC8803(SBL88乳酸菌)摂取による睡眠の質改善効果-ランダム化プラセボ対照二重盲検並行群間比較試験-
· 薬理と治療
Effects of oral intake of heat-killed Lactobacillus brevis SBC8803 (SBL88™) on dry skin conditions: A randomized, double-blind, placebo-controlled study
· Experimental and Therapeutic Medicine
Effect of dietary heat-killed Lactobacillus brevis SBC8803 (SBL88™) on sleep: a non-randomised, double blind, placebo-controlled, and crossover pilot study
· Beneficial Microbes
The serotonin receptor mediates changes in autonomic neurotransmission and gastrointestinal transit induced by heat-killed Lactobacillus brevis SBC8803
· Beneficial Microbes
Physiological activity of Lactobacillus brevis SBC8803 and probiotic-derived polyphosphate enhances the epithelial barrier function
· Japanese Journal of Lactic Acid Bacteria
Effect of heat-killed Lactobacillus brevis SBC8803 on cutaneous arterial sympathetic nerve activity, cutaneous blood flow and transepidermal water loss in rats
· Journal of Applied Microbiology
Heat-Killed Lactobacillus brevis SBC8803 Induces Serotonin Release from Intestinal Cells
· Food and Nutrition Sciences
Effect of Lactobacillus brevis SBC8803 on Gamma-Glutamyl Transferase in Japanese Habitual Drinkers: A Double-Blind, Placebo-Controlled Study
· Food and Nutrition Sciences
Heat-killed body of lactobacillus brevis SBC8803 ameliorates intestinal injury in a murine model of colitis by enhancing the intestinal barrier function
· Inflammatory Bowel Diseases
Probiotic-Derived Polyphosphate Enhances the Epithelial Barrier Function and Maintains Intestinal Homeostasis through Integrin–p38 MAPK Pathway
· PLoS ONE
Oral Administration of Heat-Killed Lactobacillus brevis SBC8803 Ameliorates the Development of Dermatitis and Inhibits Immunoglobulin E Production in Atopic Dermatitis Model NC/Nga Mice
· Biological and Pharmaceutical Bulletin
Dietary Heat-Killed Lactobacillus brevis SBC8803 (SBL88) Improves Hippocampus-Dependent Memory and Adult Hippocampal Neurogenesis
食餌性熱殺菌Lactobacillus brevis SBC8803(SBL88)は海馬依存性記憶力と成体海馬神経新生を改善する
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P-216 Oral Dietary Administration of Heat-Killed Lactobacillus Brevis SBC8803 Alters the Gut Microbiome and Ameliorates Experimental Colitis in Mice
· Inflammatory Bowel Diseases
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Citations
Selected papers that name this strain.
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[1]
Source →Sleep Quality Improvement Effects of Lactobacillus brevis SBC8803 (SBL88 Lactic Acid Bacteria) Intake: A Randomized, Placebo-Controlled, Double-Blind, Parallel-Group Comparative StudyLactobacillus brevis SBC8803（SBL88TM乳酸菌）摂取による睡眠の質改善効果―ランダム化プラセボ対照二重盲検並行群間比較試験―· 薬理と治療 · 2018
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[2]
PMID 27013460 →Effect of dietary heat-killed Lactobacillus brevis SBC8803 (SBL88™) on sleep: a non-randomised, double blind, placebo-controlled, and crossover pilot study· Beneficial Microbes · 2016
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[3]
Source →Effect of Lactobacillus brevis SBC8803 on Gamma-Glutamyl Transferase in Japanese Habitual Drinkers: A Double-Blind, Placebo-Controlled Study· Food and Nutrition Sciences · 2012