Strain Profile
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Bifidobacterium lactis Bl-04
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Human-origin
Where this strain was first isolated, curated from the literature and culture-collection catalogs. It describes provenance only — not suitability, and not benefit.
How we classify this →
Sequenced
Whether a public genome assembly is linked for this strain. Without one the genome screens cannot run. It is not a verdict on the organism.
How we classify this →
Public genome assembly available
Bifidobacterium lactis BL-04 (also classified as B. animalis subsp. lactis BL-04) has been evaluated in several randomized controlled trials examining immune and skin-related outcomes, including allergy symptoms during birch pollen season and skin hydration and wrinkle appearance. In vitro work has characterized the strain's ability to utilize prebiotic oligosaccharides and produce short-chain fatty acids. Safety assessments have examined antibiotic resistance and genomic risk factors. These are research topics, not findings; the papers do not establish that this strain treats or prevents any condition.
Where it's been studied Tags come from a conservative keyword scan of each paper's title, abstract, and summary. A tag is research coverage, not measured effect. How we classify this →
Share of this strain's 51 body-system-tagged papers that concern each system. Research coverage, not measured effect.
+5 more systems
Symptoms in the research A tag means the paper's text names the symptom or condition — research coverage, not evidence of benefit. How we classify this →
Share of this strain's 28 symptom-tagged papers that mention each symptom or condition. Research coverage, not evidence of benefit.
+10 more symptoms
Research Study-type filters use AI-classified labels, audited but not guaranteed — check the paper itself before leaning on one. How we classify this →
80 papers reference this strain in the probiotic database.
Match confidence
How strongly this paper was matched to this strain when the corpus was linked. It orders the list — it says nothing about the study's quality or its findings.
How we classify this →
2024
IN_VITRO
2023
RCT
2022
RCT
2021
OTHER
2021
RCT
2021
RCT
2021
OBSERVATIONAL
2020
OBSERVATIONAL
2019
IN_VITRO
2019
REVIEW
2018
IN_VITRO
2017
RCT
2017
ANIMAL
2017
RCT
2017
RCT
2015
OTHER
2015
OTHER
2015
OTHER
2015
OTHER
2014
OBSERVATIONAL
Browse all 80 papers →
The effect of probiotic Bifidobacterium lactis Bl-04 on innate antiviral responses in vitro
· Heliyon
Pathogenetic aspects of the development and treatment of antibiotic-associated diarrhea: the choice of a synbiotic from the standpoint of evidence-based medicine
· Meditsinskiy sovet = Medical Council
Effects of Bifidobacterium animalis subsp. lactis Bl-04 on Skin Wrinkles and Dryness: A Randomized, Triple-Blinded, Placebo-Controlled Clinical Trial
· Dermato
Characterization of the Hydrogen Peroxide Stress Responses of Bifidobacterium longum and Bifidobacterium animalis subsp. Lactis
· Digital Commons - USU (Utah State University)
A Brief Review on the First Evaluation of a Synbiotic Food Supplement in Birch Pollen Allergic Patients in an Allergen Exposure Chamber
· Journal of clinical research
Effect of fermented milk on upper respiratory tract infection in adults who lived in the haze area of Northern China: a randomized clinical trial
· Pharmaceutical Biology
An Open-label, Multicenter Study to Assess the Efficacy and Safety of a Novel Probiotic Blend in Patients With Functional Gastrointestinal Symptoms
· Journal of Clinical Gastroenterology
S0502 An Open-Label, Multicenter Study to Assess the Efficacy and Safety of a Novel Probiotic Blend in Patients With Functional Gastrointestinal Disturbances
· The American Journal of Gastroenterology
Inhibition of Antimicrobial Resistant Salmonella Heidelberg by a Synbiotic Combination of Prebiotics and Probiotics in an in Vitro Model (P20-011-19)
· Current Developments in Nutrition
Health Benefits of a Combination Probiotics; FlorMidabil™
· International Journal of Probiotics and Prebiotics
Absolute Enumeration of Probiotic Strains Lactobacillus acidophilus NCFM® and Bifidobacterium animalis subsp. lactis Bl-04® via Chip-Based Digital PCR
· Frontiers in Microbiology
Intestinal microbiota is altered in patients with colon cancer and modified by probiotic intervention
· BMJ Open Gastroenterology
Safety evaluation of HOWARU® Restore (Lactobacillus acidophilus NCFM, Lactobacillus paracasei Lpc-37, Bifidobacterium animalis subsp. lactis Bl-04 and B. lactis Bi-07) for antibiotic resistance, genomic risk factors, and acute toxicity
· Food and Chemical Toxicology
Effect of probiotic on innate inflammatory response and viral shedding in experimental rhinovirus infection – a randomised controlled trial
· Beneficial Microbes
A randomized controlled trial of probiotics for Clostridium difficile infection in adults (PICO)
· Journal of Antimicrobial Chemotherapy
Additional file 1: of The GH5 1,4-β-mannanase from Bifidobacterium animalis subsp. lactis Bl-04 possesses a low-affinity mannan-binding module and highlights the diversity of mannanolytic enzymes
· Figshare
Additional file 2: of The GH5 1,4-β-mannanase from Bifidobacterium animalis subsp. lactis Bl-04 possesses a low-affinity mannan-binding module and highlights the diversity of mannanolytic enzymes
· Figshare
Additional file 12: of The GH5 1,4-β-mannanase from Bifidobacterium animalis subsp. lactis Bl-04 possesses a low-affinity mannan-binding module and highlights the diversity of mannanolytic enzymes
· Figshare
Additional file 11: of The GH5 1,4-β-mannanase from Bifidobacterium animalis subsp. lactis Bl-04 possesses a low-affinity mannan-binding module and highlights the diversity of mannanolytic enzymes
· Figshare
Multi-strain Symbiotic Preparations as a Novel Adjuvant Approach to Allergic Rhinitis
· Journal of Contemporary Immunology
Discussion
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Citations
Selected papers that name this strain.
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[1]
PMID 34062085 →Effect of fermented milk on upper respiratory tract infection in adults who lived in the haze area of Northern China: a randomized clinical trial· Pharmaceutical Biology · 2021
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[2]
PMID 29696008 →Absolute Enumeration of Probiotic Strains Lactobacillus acidophilus NCFM® and Bifidobacterium animalis subsp. lactis Bl-04® via Chip-Based Digital PCR· Frontiers in Microbiology · 2018
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[3]
PMID 28343401 →Effect of probiotic on innate inflammatory response and viral shedding in experimental rhinovirus infection – a randomised controlled trial· Beneficial Microbes · 2017
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[4]
Source →Probiotic Lactobacillus acidophilus NCFM and Bifidobacterium animalis subsp lactis Bl-04 interactions with prebiotic carbohydrates using differential proteomics and protein characterization· · 2012
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[5]
PMID 19598302 →Specific probiotics alleviate allergic rhinitis during the birch pollen season· World Journal of Gastroenterology · 2009
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[6]
PMID 18422632 →Effects of seven potential probiotic strains on specific immune responses in healthy adults: a double-blind, randomized, controlled trial· FEMS Immunology & Medical Microbiology · 2008