Strain Profile
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Bifidobacterium longum NCC3001
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Human-origin
Where this strain was first isolated, curated from the literature and culture-collection catalogs. It describes provenance only — not suitability, and not benefit.
How we classify this →
Sequenced
Whether a public genome assembly is linked for this strain. Without one the genome screens cannot run. It is not a verdict on the organism.
How we classify this →
Public genome assembly available
Bifidobacterium longum NCC3001 has one of the more developed gut-brain research profiles among probiotic strains. It has been studied in randomized controlled trials examining psychological wellbeing, including perinatal mood, anxiety, and quality of life in adults with irritable bowel syndrome, as well as perceived stress. Mechanistic work in animal models and in vitro settings has examined vagal nerve signaling as a potential pathway between gut and brain. These are research topics, not findings; the papers do not establish that this strain treats or prevents any condition.
Where it's been studied Tags come from a conservative keyword scan of each paper's title, abstract, and summary. A tag is research coverage, not measured effect. How we classify this →
Share of this strain's 11 body-system-tagged papers that concern each system. Research coverage, not measured effect.
+1 more systems
Symptoms in the research A tag means the paper's text names the symptom or condition — research coverage, not evidence of benefit. How we classify this →
Share of this strain's 10 symptom-tagged papers that mention each symptom or condition. Research coverage, not evidence of benefit.
Research Study-type filters use AI-classified labels, audited but not guaranteed — check the paper itself before leaning on one. How we classify this →
15 papers reference this strain in the probiotic database.
Match confidence
How strongly this paper was matched to this strain when the corpus was linked. It orders the list — it says nothing about the study's quality or its findings.
How we classify this →
2025
RCT
2024
RCT
2023
RCT
2023
RCT
2013
IN_VITRO
2012
IN_VITRO
2011
ANIMAL
2009
IN_VITRO
2026
REVIEW
2024
REVIEW
2022
RCT
2021
REVIEW
2026
REVIEW
2024
REVIEW
2020
IN_VITRO
Browse all 15 papers →
The impact of ingestion of Bifidobacterium longum NCC3001 on perinatal anxiety and depressive symptoms: a randomized controlled trial
· Scientific Reports
Metabolome-associated psychological comorbidities improvement in irritable bowel syndrome patients receiving a probiotic
· Gut Microbes
Bifidobacterium longum subsp. longum Reduces Perceived Psychological Stress in Healthy Adults: An Exploratory Clinical Trial
· Nutrients
A Probiotic Intervention With Bifidobacterium longum NCC3001 on Perinatal Mood Outcomes (PROMOTE Study): Protocol for a Decentralized Randomized Controlled Trial
· JMIR Research Protocols
Bifidobacterium longum NCC3001 inhibits AH neuron excitability
· Neurogastroenterology & Motility
The Effects of Bifidobacterium Longum NCC3001 on AH Neuron Excitability and Slow Wave Activity of the Mouse Intestine
· MacSphere (McMaster University)
The anxiolytic effect of Bifidobacterium longum NCC3001 involves vagal pathways for gut-brain communication
· Neurogastroenterology & Motility
Reconstitution conditions for dried probiotic powders represent a critical step in determining cell viability
· Journal of Applied Microbiology
Microbiome-Driven Regulation of Brain Function: Molecular Pathways Linking Gut and Neuropsychiatric Health
· Journal of Advances in Biology & Biotechnology
Unlocking the Secrets of Probiotics – A Therapeutic Breakthrough for Major Depressive Disorders
· Journal of Biological Regulators and Homeostatic Agents/Journal of Biological Regulators & Homeostatic Agents
A Probiotic Intervention With Bifidobacterium longum NCC3001 on Perinatal Mood Outcomes (PROMOTE Study): Protocol for a Decentralized Randomized Controlled Trial (Preprint)
·
The Role of Bifidobacteria in Predictive and Preventive Medicine: A Focus on Eczema and Hypercholesterolemia
· Microorganisms
The Psychobiome: Microbial Metabolites as Master Regulators of Anxiety, Depression, and Antidepressant Response
· Ricos Biology
Potential role of gut microbiota in major depressive disorder: A review
· Heliyon
Structure and Function of Bovine Whey Derived Oligosaccharides Showing Synbiotic Epithelial Barrier Protective Properties
· Nutrients
Discussion
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Citations
Selected papers that name this strain.
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[1]
PMID 40175540 →The impact of ingestion of Bifidobacterium longum NCC3001 on perinatal anxiety and depressive symptoms: a randomized controlled trial· Scientific Reports · 2025
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[2]
PMID 38717445 →Metabolome-associated psychological comorbidities improvement in irritable bowel syndrome patients receiving a probiotic· Gut Microbes · 2024
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[3]
PMID 37513541 →Bifidobacterium longum subsp. longum Reduces Perceived Psychological Stress in Healthy Adults: An Exploratory Clinical Trial· Nutrients · 2023
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[4]
PMID 37018024 →A Probiotic Intervention With Bifidobacterium longum NCC3001 on Perinatal Mood Outcomes (PROMOTE Study): Protocol for a Decentralized Randomized Controlled Trial· JMIR Research Protocols · 2023
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[5]
Source →A Probiotic Intervention With Bifidobacterium longum NCC3001 on Perinatal Mood Outcomes (PROMOTE Study): Protocol for a Decentralized Randomized Controlled Trial (Preprint)· · 2022
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[6]
PMID 33919907 →The Role of Bifidobacteria in Predictive and Preventive Medicine: A Focus on Eczema and Hypercholesterolemia· Microorganisms · 2021
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[7]
PMID 23663494 →Bifidobacterium longum NCC3001 inhibits AH neuron excitability· Neurogastroenterology & Motility · 2013
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[8]
Source →The Effects of Bifidobacterium Longum NCC3001 on AH Neuron Excitability and Slow Wave Activity of the Mouse Intestine· MacSphere (McMaster University) · 2012
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[9]
PMID 21988661 →The anxiolytic effect of Bifidobacterium longum NCC3001 involves vagal pathways for gut-brain communication· Neurogastroenterology & Motility · 2011
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[10]
PMID 19796125 →Reconstitution conditions for dried probiotic powders represent a critical step in determining cell viability· Journal of Applied Microbiology · 2009