Strain Profile
· NCBI Strain Taxon
880633
NCBI Taxonomy's node for this specific strain. A different identifier from the culture-collection deposit numbers below, which name a physical stock rather than a taxonomic node.
How we classify this →
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Lactobacillus helveticus R0052
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Food-origin
Where this strain was first isolated, curated from the literature and culture-collection catalogs. It describes provenance only — not suitability, and not benefit.
How we classify this →
Sequenced
Whether a public genome assembly is linked for this strain. Without one the genome screens cannot run. It is not a verdict on the organism.
How we classify this →
Public genome assembly available
Lactobacillus helveticus R0052 is most often studied in combination with Bifidobacterium longum R0175, a pairing investigated in the context of the gut-brain axis (the bidirectional communication network linking intestinal microbes to the central nervous system). Animal model work has explored mood-related outcomes following this combination, and at least one small human randomized controlled trial examined brain responses to emotional tasks, though the multi-strain design means outcomes cannot be attributed to R0052 alone. Additional human RCTs have assessed the broader combination in healthy adults and in infants. These are research topics, not findings; the papers do not establish that this strain treats or prevents any condition.
Where it's been studied Tags come from a conservative keyword scan of each paper's title, abstract, and summary. A tag is research coverage, not measured effect. How we classify this →
Share of this strain's 101 body-system-tagged papers that concern each system. Research coverage, not measured effect.
+3 more systems
Symptoms in the research A tag means the paper's text names the symptom or condition — research coverage, not evidence of benefit. How we classify this →
Share of this strain's 58 symptom-tagged papers that mention each symptom or condition. Research coverage, not evidence of benefit.
Research Study-type filters use AI-classified labels, audited but not guaranteed — check the paper itself before leaning on one. How we classify this →
128 papers reference this strain in the probiotic database.
Match confidence
How strongly this paper was matched to this strain when the corpus was linked. It orders the list — it says nothing about the study's quality or its findings.
How we classify this →
2025
IN_VITRO
2025
RCT
2025
RCT
2025
IN_VITRO
2025
ANIMAL
2025
ANIMAL
2025
RCT
2024
ANIMAL
2024
IN_VITRO
2024
RCT
2023
OBSERVATIONAL
2023
OBSERVATIONAL
2023
RCT
2023
RCT
2023
IN_VITRO
2022
RCT
2022
RCT
2022
ANIMAL
2022
RCT
2022
IN_VITRO
Browse all 128 papers →
Lactobacillus helveticus Encapsulated by Ionic Gelation with Sodium Alginate: A Controlled Release Study in Peanut Butter
· ACS Food Science & Technology
Pilot Trial of Probiotics in Major Depressive Disorder: A Randomized, Double-Blind, Placebo-Controlled Approach
· Progress In Microbes & Molecular Biology
A Randomized Controlled Trial Evaluating the Effects of a Probiotic Containing Lactobacillus helveticus R0052 and Bifidobacterium longum R0175 on Gastrointestinal Symptoms and Metabolomic Profiles in Female Dancers
· International Journal of Molecular Sciences
Restoring Balance: Probiotic Modulation of Microbiota, Metabolism, and Inflammation in SSRI-Induced Dysbiosis Using the SHIME® Model
· Pharmaceuticals
Lactobacillus helveticus R0052 and Bifidobacterium longum R0175 administration to Long–Evans rats has interactive effects with sex and diet on anxiety-related feeding behaviors and specific endocrine outcomes
· Physiology & Behavior
Lactobacillus helveticus R0052 attenuates DSS-induced colitis via modulation of gut microbiota, intestinal metabolites and immunological profiles in a mouse model
· Microbial Pathogenesis
Does isovaleric acid play a key role in the interaction between probiotics and antidepressants? A secondary analysis of a randomized clinical trial
· Computational and Structural Biotechnology Journal
Probiotics Alter the Microbial and Behavioral Consequences of Methamphetamine Exposure in a Sex-Selective Manner
· Psychoactives
Development of functional peanut paste containing lactobacillus helveticus encapsulated by ionic gelification
· LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)
The effect of probiotic-fortified kefir on cardiovascular risk factors in elderly population: a double-blind, randomized, placebo-controlled clinical trial
· BMC Nutrition
USE OF PROBIOTICS IN ALLERGIC RHINITS: A PILOT STUDY
· Journal of Contemporary Diseases and Advanced Medicine
Total Transit Time and Probiotic Persistence in Healthy Adults: A Pilot Study
· Journal of Neurogastroenterology and Motility
Efficacy and safety of Lacticaseibacillus rhamnosus R0011 and Lactobacillus helveticus R0052 as an adjuvant for Helicobacter pylori eradication: a double-blind, randomized, placebo-controlled study
· Frontiers in Gastroenterology
Psychobiotic Effects on Anxiety Are Modulated by Lifestyle Behaviors: A Randomized Placebo-Controlled Trial on Healthy Adults
· Nutrients
Exploring the Potential of Lactobacillus helveticus R0052 and Bifidobacterium longum R0175 as Promising Psychobiotics Using SHIME
· Nutrients
Beneficial Shifts in Gut Microbiota by Lacticaseibacillus rhamnosus R0011 and Lactobacillus helveticus R0052 in Alcoholic Hepatitis
· Microorganisms
Promises for patients with disturbed gut-brain axis signalling: Does the intake of a probiotic mixture improve mental health of healthy subjects?
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The effects of antimicrobials and lipopolysaccharide on acute immune responsivity in pubertal male and female CD1 mice
· Comprehensive Psychoneuroendocrinology
Probiotic Mixture Containing Lactobacillus helveticus, Bifidobacterium longum and Lactiplantibacillus plantarum Affects Brain Responses Toward an Emotional Task in Healthy Subjects: A Randomized Clinical Trial
· Frontiers in Nutrition
In Vitro Probiotic Modulation of the Intestinal Microbiota and 2′Fucosyllactose Consumption in Fecal Cultures from Infants at Two Months of Age
· Microorganisms
Discussion
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Citations
Selected papers that name this strain.
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[1]
PMID 41821821 →Efficacy and safety of Lacticaseibacillus rhamnosus R0011 and Lactobacillus helveticus R0052 as an adjuvant for Helicobacter pylori eradication: a double-blind, randomized, placebo-controlled study· Frontiers in Gastroenterology · 2023
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[2]
Source →Promises for patients with disturbed gut-brain axis signalling: Does the intake of a probiotic mixture improve mental health of healthy subjects?· · 2022
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[3]
Source →O3 Changes in gut microbiota after synbiotic supplementation in patients with systemic lupus erythematosus: a randomised, double-blind, placebo-controlled trial· Oral Presentations · 2020
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[4]
PMID 31965842 →Probiotics maintain intestinal secretory immunoglobulin A levels in healthy formula-fed infants: a randomised, double-blind, placebo-controlled study· Beneficial Microbes · 2019
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[5]
PMID 28555502 →Safety and tolerance of three probiotic strains in healthy infants: a multi-centre randomized, double-blind, placebo-controlled trial· Beneficial Microbes · 2017
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[6]
Source →Probiotic Lacidofil® STRONG Mitigates the Antibiotic‐Induced Alteration of the Fecal microRNA Signature in Healthy Humans· The FASEB Journal · 2016
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[7]
Source →Experience using probiotic strains Lactobacillus acidophilus R0052 and Lactobacillus rhamnosus R0011 in children with burn injuriesДосвід використання пробіотичних штамів Lactobacillus acidophilus R0052 та Lactobacillus rhamnosus R0011 у дітей з опіковою травмою· GASTROENTEROLOGY · 2016
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[8]
Source →Amélioration de la croissance et de la survie en conditions gastrointestinales de bactéries probiotiques sensibles à l'oxygène, microencapsulées ou non, en présence d'un extrait de thé vert· · 2015
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[9]
PMID 22146691 →A comprehensive post-market review of studies on a probiotic product containing Lactobacillus helveticus R0052 and Lactobacillus rhamnosus R0011· Beneficial Microbes · 2011
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[10]
Source →Randomized, placebo-controlled trial on clinical and immunologic effects of probiotic containing Lactobacillus rhamnosus R0011 and L. helveticus R0052 in infants with atopic dermatitis· Microbial Ecology in Health and Disease · 2009