Strain Profile
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Lacticaseibacillus rhamnosus CNCM I-4036
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Food-origin
Where this strain was first isolated, curated from the literature and culture-collection catalogs. It describes provenance only — not suitability, and not benefit.
How we classify this →
Sequenced
Whether a public genome assembly is linked for this strain. Without one the genome screens cannot run. It is not a verdict on the organism.
How we classify this →
Public genome assembly available
Lacticaseibacillus rhamnosus CNCM I-4036 was originally isolated from the feces of exclusively breastfed infants and has since been studied alongside two companion strains (L. paracasei CNCM I-4034 and B. breve CNCM I-4035). In vitro work has examined inflammatory cytokine responses in intestinal epithelial cells and interactions with certain enteric pathogens under laboratory conditions. Randomized trials in healthy adults have studied safety and immunomodulatory markers following supplementation, and animal studies have examined liver fat and intestinal inflammation markers in metabolic disease models. These are research topics, not findings; the papers do not establish that this strain treats or prevents any condition.
Where it's been studied Tags come from a conservative keyword scan of each paper's title, abstract, and summary. A tag is research coverage, not measured effect. How we classify this →
Share of this strain's 16 body-system-tagged papers that concern each system. Research coverage, not measured effect.
Symptoms in the research A tag means the paper's text names the symptom or condition — research coverage, not evidence of benefit. How we classify this →
Share of this strain's 8 symptom-tagged papers that mention each symptom or condition. Research coverage, not evidence of benefit.
Research Study-type filters use AI-classified labels, audited but not guaranteed — check the paper itself before leaning on one. How we classify this →
16 papers reference this strain in the probiotic database.
Match confidence
How strongly this paper was matched to this strain when the corpus was linked. It orders the list — it says nothing about the study's quality or its findings.
How we classify this →
2021
OBSERVATIONAL
2021
ANIMAL
2017
ANIMAL
2015
RCT
2014
ANIMAL
2014
IN_VITRO
2013
IN_VITRO
2013
IN_VITRO
2013
IN_VITRO
2013
RCT
2023
IN_VITRO
2022
OBSERVATIONAL
2017
ANIMAL
2017
REVIEW
2014
OTHER
2012
OTHER
Browse all 16 papers →
Differential health effects on inflammatory, immunological and stress parameters in professional soccer players and sedentary individuals after consuming a synbiotic. A triple blinded, randomized, placebo-controlled pilot study.
· RIUCAM
Bifidobacterium breve CNCM I-4035, Lactobacillus paracasei CNCM I-4034 and Lactobacillus rhamnosus CNCM I-4036 Modulate Macrophage Gene Expression and Ameliorate Damage Markers in the Liver of Zucker-Leprfa/fa Rats
· Nutrients
Adamdec1, Ednrb and Ptgs1/Cox1, inflammation genes upregulated in the intestinal mucosa of obese rats, are downregulated by three probiotic strains
· Scientific Reports
Pyrosequencing Analysis Reveals Changes in Intestinal Microbiota of Healthy Adults Who Received a Daily Dose of Immunomodulatory Probiotic Strains
· Nutrients
Effects of Lactobacillus paracasei CNCM I-4034, Bifidobacterium breve CNCM I-4035 and Lactobacillus rhamnosus CNCM I-4036 on Hepatic Steatosis in Zucker Rats
· PLoS ONE
Lactobacillus rhamnosus and its cell-free culture supernatant differentially modulate inflammatory biomarkers in Escherichia coli-challenged human dendritic cells
· British Journal Of Nutrition
Lactobacillus rhamnosus CNCM I-4036 decrease inflammatory cytokine release in human intestinal epithelial cells induced by enterotoxigenic Escherichia coli
· Proceedings of The Nutrition Society
Isolation, identification and characterisation of three novel probiotic strains (Lactobacillus paracasei CNCM I-4034, Bifidobacterium breve CNCM I-4035 and Lactobacillus rhamnosus CNCM I-4036) from the faeces of exclusively breast-fed infants
· British Journal Of Nutrition
Competitive inhibition of three novel bacteria isolated from faeces of breast milk-fed infants against selected enteropathogens
· British Journal Of Nutrition
Safety and Immunomodulatory Effects of Three Probiotic Strains Isolated from the Feces of Breast-Fed Infants in Healthy Adults: SETOPROB Study
· PLoS ONE
3D printing of microencapsulated Lactobacillus rhamnosus for oral delivery
· International Journal of Pharmaceutics
The Consumption of a Synbiotic Does Not Affect the Immune, Inflammatory, and Sympathovagal Parameters in Athletes and Sedentary Individuals: A Triple-Blinded, Randomized, Place-bo-Controlled Pilot Study
· International Journal of Environmental Research and Public Health
Gene expression profiling in the intestinal mucosa of obese rats administered probiotic bacteria
· Scientific Data
Efecto de Lactobacillus paracasei CNCM I-4034, Lactobacillus rhamnosus CNCM I-4036 y Bifidobacterium breve CNCM I-4035 sobre la expresión génica de la mucosa intestinal de ratas obesas
· Tesis Doctorals en Xarxa (Consorci de Serveis Universitaris de Catalunya)
Colonización, seguridad y tolerancia de Lactobacillus paracasei CNCM I-4034, Lactobacillus rhamnosus CNCM I-4036 y Bifidobacterium breve CNCM I-4035 en adultos sanos y sus efectos sobre el metabolismo y sistema inmunitario en ratas Zucker
· Institutional Repository of the University of Granada (University of Granada)
Efecto de las cepas probióticas Lactobacillus paracasei CNCM I-4034, Bifidobacterium breve CNCM I-4035 y Lactobacillus rhamnosus CNCM I-4036, sobre la respuesta inmunitaria en células intestinales humanas
· Institutional Repository of the University of Granada (University of Granada)
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Citations
Selected papers that name this strain.
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[1]
Source →Differential health effects on inflammatory, immunological and stress parameters in professional soccer players and sedentary individuals after consuming a synbiotic. A triple blinded, randomized, placebo-controlled pilot study.· RIUCAM · 2021
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[2]
PMID 24205115 →Safety and Immunomodulatory Effects of Three Probiotic Strains Isolated from the Feces of Breast-Fed Infants in Healthy Adults: SETOPROB Study· PLoS ONE · 2013