Strain Profile
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Lacticaseibacillus rhamnosus LRa05
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Food-origin
Where this strain was first isolated, curated from the literature and culture-collection catalogs. It describes provenance only — not suitability, and not benefit.
How we classify this →
Sequenced
Whether a public genome assembly is linked for this strain. Without one the genome screens cannot run. It is not a verdict on the organism.
How we classify this →
Public genome assembly available
Lacticaseibacillus rhamnosus LRa05 is an emerging probiotic strain with a growing evidence base spanning animal models and several randomized controlled trials. Human RCTs have examined gut microbiota composition, and early clinical trials have examined acute childhood diarrhea, Helicobacter pylori eradication as an adjunct, and metabolic parameters in individuals who consume alcohol. Animal model research has further explored immune modulation and intestinal barrier function, particularly in inflammatory colitis models. The evidence base for LRa05 is still developing; findings are preliminary and the strain should not be considered a treatment for any specific gastrointestinal or metabolic condition. These are research topics, not findings; the papers do not establish that this strain treats or prevents any condition.
Where it's been studied Tags come from a conservative keyword scan of each paper's title, abstract, and summary. A tag is research coverage, not measured effect. How we classify this →
Share of this strain's 17 body-system-tagged papers that concern each system. Research coverage, not measured effect.
Symptoms in the research A tag means the paper's text names the symptom or condition — research coverage, not evidence of benefit. How we classify this →
Share of this strain's 7 symptom-tagged papers that mention each symptom or condition. Research coverage, not evidence of benefit.
+3 more symptoms
Research Study-type filters use AI-classified labels, audited but not guaranteed — check the paper itself before leaning on one. How we classify this →
24 papers reference this strain in the probiotic database.
Match confidence
How strongly this paper was matched to this strain when the corpus was linked. It orders the list — it says nothing about the study's quality or its findings.
How we classify this →
2026
ANIMAL
2026
OTHER
2026
WGS
2026
RCT
2025
ANIMAL
2025
ANIMAL
2025
RCT
2024
ANIMAL
2024
ANIMAL
2024
RCT
2024
RCT
2024
WGS
2023
RCT
2017
ANIMAL
2026
RCT
2026
RCT
2025
ANIMAL
2025
RCT
2025
RCT
2025
IN_VITRO
Browse all 24 papers →
Lacticaseibacillus rhamnosus LRa05 mitigates DSS-Induced colitis via boosting beneficial gut microbiota and facilitating CD4⁺Foxp3⁺ Treg differentiation
· BMC Microbiology
Genetic characterization of Lacticaseibacillus rhamnosus LRa05
· China National GeneBank DataBase
Whole genome sequencing of Lacticaseibacillus rhamnosus LRa05
· China National GeneBank DataBase
Enhancing gastrointestinal survival of probiotics using calcium alginate-based liquid-core beads: A strategy for modulating the gut microbiota in children
· Food Hydrocolloids for Health
Longitudinal Analysis of the Immunostimulatory Properties and Safety Profile of Lacticaseibacillus rhamnosus LRa05 as a Dietary Supplement
· Journal of Microbiology and Biotechnology
The effect of Lacticaseibacillus rhamnosus LRa05 probiotic tablets on the immune function of mice and its safety
· Journal of Functional Foods
Impact of Bifidobacterium animalis subsp. lactis BLa80 and Lacticaseibacillus rhamnosus LRa05 supplementation on the gut microbiota and metabolic health of alcohol-consuming individuals: a randomised, double-blind, placebo-controlled trial
· Beneficial Microbes
Lacticaseibacillus rhamnosus LRa05 mediates dynamic regulation of intestinal microbiota in mice with low-dose DSS-induced chronic mild inflammation
· Frontiers in Microbiology
Lacticaseibacillus rhamnosus LRa05 alleviates cyclophosphamide‐induced immunosuppression and intestinal microbiota disorder in mice
· Journal of Food Science
Evaluation of efficacy and safety of Lacticaseibacillus rhamnosus LRa05 in the eradication of Helicobacter pylori: a randomized, double-blind, placebo-controlled trial
· Frontiers in Immunology
Lacticaseibacillus rhamnosus LRa05 in the treatment of acute diarrhea in children: a randomized controlled trial
· Frontiers in Nutrition
In vitro and in vivo genome-based safety evaluation of Lacticaseibacillus rhamnosus LRa05
· Food and Chemical Toxicology
Changes in the gut microbiota composition of healthy young volunteers after administration of Lacticaseibacillus rhamnosus LRa05: A placebo-controlled study
· Frontiers in Nutrition
Lacticaseibacillus rhamnosus LRa05 alleviated liver injury in mice with alcoholic fatty liver disease by improving intestinal permeability and balancing gut microbiota
· Beneficial Microbes
Multi‐Strain Probiotics BLa80, LRa05, and BBr60 Modulate Inflammation, Bile Acids, and Gut Microbiota in Type 2 Diabetes: A Randomized Controlled Trial
· Food Science & Nutrition
Safety and Efficacy of Lacticaseibacillus rhamnosus LRa05, Limosilactobacillus reuteri LR08 and Lactobacillus crispatus LCr86 on Hormone Metabolism, Body Composition, and Emotional Regulation in Overweight Women: A Randomized, Double - Blind, Placebo - Controlled Trial
· Journal of Applied Microbiology
Postbiotics and extracellular polysaccharides of Lacticaseibacillus rhamnosus LRa05 alleviate loperamide-induced constipation via gut microbiota
· Food Bioscience
Efficacy and Safety of a Probiotic Mixture Containing Bifidobacterium animalis subsp. lactis BLa80 and Lacticaseibacillus rhamnosus LRa05 in Children With Attention‐Deficit/Hyperactivity Disorder
· Molecular Nutrition & Food Research
Multi-Strain Probiotics Alleviate Alcoholic Liver Disease Via Microbiota–Metabolism Axis: A Randomized Controlled Study
· Probiotics and Antimicrobial Proteins
The chemical rheological properties of pea protein dough and the storage stability of pea steamed bread were improved and the beany flavor was reduced by cooperative fermentation
· Journal of the Science of Food and Agriculture
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Citations
Selected papers that name this strain.
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[1]
Source →Safety and Efficacy of Lacticaseibacillus rhamnosus LRa05, Limosilactobacillus reuteri LR08 and Lactobacillus crispatus LCr86 on Hormone Metabolism, Body Composition, and Emotional Regulation in Overweight Women: A Randomized, Double - Blind, Placebo - Controlled Trial· Journal of Applied Microbiology · 2026
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[2]
Source →Enhancing gastrointestinal survival of probiotics using calcium alginate-based liquid-core beads: A strategy for modulating the gut microbiota in children· Food Hydrocolloids for Health · 2026
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[3]
PMID 40527514 →Impact of Bifidobacterium animalis subsp. lactis BLa80 and Lacticaseibacillus rhamnosus LRa05 supplementation on the gut microbiota and metabolic health of alcohol-consuming individuals: a randomised, double-blind, placebo-controlled trial· Beneficial Microbes · 2025
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[4]
PMID 39234246 →Evaluation of efficacy and safety of Lacticaseibacillus rhamnosus LRa05 in the eradication of Helicobacter pylori: a randomized, double-blind, placebo-controlled trial· Frontiers in Immunology · 2024
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[5]
PMID 39619284 →Lacticaseibacillus rhamnosus LRa05 in the treatment of acute diarrhea in children: a randomized controlled trial· Frontiers in Nutrition · 2024
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[6]
PMID 36998912 →Changes in the gut microbiota composition of healthy young volunteers after administration of Lacticaseibacillus rhamnosus LRa05: A placebo-controlled study· Frontiers in Nutrition · 2023