Strain Profile
· NCBI Strain Taxon
486408
NCBI Taxonomy's node for this specific strain. A different identifier from the culture-collection deposit numbers below, which name a physical stock rather than a taxonomic node.
How we classify this →
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Lacticaseibacillus rhamnosus HN001
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Food-origin
Where this strain was first isolated, curated from the literature and culture-collection catalogs. It describes provenance only — not suitability, and not benefit.
How we classify this →
Sequenced
Whether a public genome assembly is linked for this strain. Without one the genome screens cannot run. It is not a verdict on the organism.
How we classify this →
Public genome assembly available
Lacticaseibacillus rhamnosus HN001 (formerly classified as Lactobacillus rhamnosus HN001) has been studied across in vitro, animal, and human randomized controlled trial settings. In vitro research has examined activity against certain bacterial and fungal pathogens under laboratory conditions, while RCT-level evidence has examined constipation, IBS symptoms, and pregnancy-related outcomes. Animal model work has examined immune modulation and gut barrier function, though findings in animal models do not always translate directly to human outcomes. The available evidence is early to moderate in maturity; individual results may vary and this strain should not be viewed as a treatment for any specific condition. These are research topics, not findings; the papers do not establish that this strain treats or prevents any condition.
Where it's been studied Tags come from a conservative keyword scan of each paper's title, abstract, and summary. A tag is research coverage, not measured effect. How we classify this →
Share of this strain's 157 body-system-tagged papers that concern each system. Research coverage, not measured effect.
Symptoms in the research A tag means the paper's text names the symptom or condition — research coverage, not evidence of benefit. How we classify this →
Share of this strain's 84 symptom-tagged papers that mention each symptom or condition. Research coverage, not evidence of benefit.
+15 more symptoms
Research Study-type filters use AI-classified labels, audited but not guaranteed — check the paper itself before leaning on one. How we classify this →
213 papers reference this strain in the probiotic database.
Match confidence
How strongly this paper was matched to this strain when the corpus was linked. It orders the list — it says nothing about the study's quality or its findings.
How we classify this →
2026
IN_VITRO
2026
RCT
2026
IN_VITRO
2026
IN_VITRO
2026
RCT
2026
RCT
2025
OTHER
2025
RCT
2025
ANIMAL
2025
IN_VITRO
2025
REVIEW
2024
IN_VITRO
2024
IN_VITRO
2023
IN_VITRO
2023
RCT
2022
RCT
2022
ANIMAL
2022
REVIEW
2021
ANIMAL
2021
RCT
Browse all 213 papers →
Dataset for Lacticaseibacillus rhamnosus HN001 enhances intestinal barrier function and protects the blood-brain barrier from inflammatory disruption in vitro
· AgResearch
Probiotic effects on brain health are both transient and sustained for several weeks after discontinuation: a randomised controlled trial
· Communications Medicine
Lacticaseibacillus rhamnosus HN001 enhances intestinal barrier function and protects the blood-brain barrier from inflammatory disruption in vitro
· AgResearch
Lacticaseibacillus rhamnosus HN001 enhances intestinal barrier function and protects the blood-brain barrier from inflammatory disruption in vitro
· Frontiers in Physiology
Two-strain probiotic supplementation ameliorates physiological responses to running in the heat
· Physiology
Effects of a strain-specific probiotic formulation on subjective sleep quality: a randomized, double-blind study
· Journal of Biological Research - Bollettino della Società Italiana di Biologia Sperimentale
Probiotic strain identification and safety assessment of unlabeled bacteria in infant products
· International Journal of Food Microbiology
Micro-encapsulation differentially impacts probiotic effects on brain structure and function in an elderly population – A randomised placebo-controlled trial
· Brain Behavior and Immunity
Reproductive experience influences the effects of Lactocaseibacillus rhamnosus HN001 on gut microbiota and hippocampal plasticity in female rats
· Journal of Neuroendocrinology
Tradescantia spathacea extract as biostimulating in growth and biological activities of Lactobacillus acidophilus and Lacticaseibacillus rhamnosus
· Ecosistemas y Recursos Agropecuarios
The therapeutic effects of Lacticaseibacillus rhamnosus on stress-induced anxiety: a systematic review of evidence from animal studies
· Gut Microbiome
Sodium Deoxycholate-Propidium Monoazide Droplet Digital PCR for Rapid and Quantitative Detection of Viable Lacticaseibacillus rhamnosus HN001 in Compound Probiotic Products
· Microorganisms
Antagonistic and antibacterial activity of Lactobacillus rhamnosus HN001 and Lactobacillus acidophilus La-14 included in the oral probiotic
· Journal of obstetrics and women s diseases
Inhibition of Toxic Shock Syndrome-Associated Staphylococcus aureus by Probiotic Lactobacilli
· Microbiology Spectrum
A Healthy Vaginal Microbiota Remains Stable during Oral Probiotic Supplementation: A Randomised Controlled Trial
· Microorganisms
Adjuvant use of multispecies probiotic in the treatment of peri‐implant mucositis: A randomized controlled trial
· Journal Of Clinical Periodontology
Lactobacillus rhamnosus HN001 Ameliorates BEZ235-Induced Intestinal Dysbiosis and Prolongs Cardiac Transplant Survival
· Microbiology Spectrum
Renaissance of the vaginal microbiota: reframing clinical paradigms
· Russian Journal of Woman and Child Health
The Possible Role of Bifidobacterium longum BB536 and Lactobacillus rhamnosus HN001 on Locomotor Activity and Oxidative Stress in a Rotenone‐Induced Zebrafish Model of Parkinson’s Disease
· Oxidative Medicine and Cellular Longevity
Effect of Lactobacillus rhamnosus Probiotic in Early Pregnancy on Plasma Conjugated Bile Acids in a Randomised Controlled Trial
· Nutrients
Discussion
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Citations
Selected papers that name this strain.
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[1]
Source →Lacticaseibacillus rhamnosus HN001 enhances intestinal barrier function and protects the blood-brain barrier from inflammatory disruption in vitro· AgResearch · 2026
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[2]
PMID 42521749 →Probiotic effects on brain health are both transient and sustained for several weeks after discontinuation: a randomised controlled trial· Communications Medicine · 2026
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[3]
PMID 42180834 →Lacticaseibacillus rhamnosus HN001 enhances intestinal barrier function and protects the blood-brain barrier from inflammatory disruption in vitro· Frontiers in Physiology · 2026
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[4]
Source →Dataset for Lacticaseibacillus rhamnosus HN001 enhances intestinal barrier function and protects the blood-brain barrier from inflammatory disruption in vitro· AgResearch · 2026
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[5]
PMID 35634695 →Adjuvant use of multispecies probiotic in the treatment of peri‐implant mucositis: A randomized controlled trial· Journal Of Clinical Periodontology · 2022
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[6]
Source →Effects of Lactobacillus rhamnosus HN001 in Early Life on the Cumulative Prevalence of Allergic Disease to 11 Years· PEDIATRICS · 2019
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[7]
PMID 30430649 →Effects of Lactobacillus rhamnosus HN001 in early life on the cumulative prevalence of allergic disease to 11 years· Pediatric Allergy and Immunology · 2018
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[8]
PMID 29540160 →Effect of Lactobacillus rhamnosus HN001 on carriage of Staphylococcus aureus: results of the impact of probiotics for reducing infections in veterans (IMPROVE) study· BMC Infectious Diseases · 2018
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[9]
PMID 28943228 →Effect of Lactobacillus rhamnosus HN001 in Pregnancy on Postpartum Symptoms of Depression and Anxiety: A Randomised Double-blind Placebo-controlled Trial· EBioMedicine · 2017
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[10]
PMID 28367765 →Early pregnancy probiotic supplementation with Lactobacillus rhamnosus HN001 may reduce the prevalence of gestational diabetes mellitus: a randomised controlled trial· British Journal Of Nutrition · 2017