Strain Profile
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Lactococcus lactis NZ9000
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Food-origin
Where this strain was first isolated, curated from the literature and culture-collection catalogs. It describes provenance only — not suitability, and not benefit.
How we classify this →
Sequenced
Whether a public genome assembly is linked for this strain. Without one the genome screens cannot run. It is not a verdict on the organism.
How we classify this →
Public genome assembly available
Lactococcus lactis NZ9000 is a well-characterized laboratory strain of L. lactis used as a genetic engineering platform rather than as a conventional probiotic. Research associated with this strain focuses primarily on its use as a vector for expressing foreign proteins, including vaccine antigens, antimicrobial peptides, and immunomodulatory molecules, in in vitro and animal settings. Preclinical models have examined oral delivery of recombinant proteins using this strain. NZ9000 is best understood as a research and bioengineering tool; it is not a recognized commercial probiotic strain with established human efficacy data. These are research topics, not findings; the papers do not establish that this strain treats or prevents any condition.
Where it's been studied Tags come from a conservative keyword scan of each paper's title, abstract, and summary. A tag is research coverage, not measured effect. How we classify this →
Share of this strain's 84 body-system-tagged papers that concern each system. Research coverage, not measured effect.
Symptoms in the research A tag means the paper's text names the symptom or condition — research coverage, not evidence of benefit. How we classify this →
Share of this strain's 20 symptom-tagged papers that mention each symptom or condition. Research coverage, not evidence of benefit.
+1 more symptoms
Research Study-type filters use AI-classified labels, audited but not guaranteed — check the paper itself before leaning on one. How we classify this →
259 papers reference this strain in the probiotic database.
Match confidence
How strongly this paper was matched to this strain when the corpus was linked. It orders the list — it says nothing about the study's quality or its findings.
How we classify this →
2026
IN_VITRO
2026
IN_VITRO
2025
IN_VITRO
2025
IN_VITRO
2025
ANIMAL
2025
IN_VITRO
2024
IN_VITRO
2023
IN_VITRO
2023
ANIMAL
2023
IN_VITRO
2023
ANIMAL
2022
IN_VITRO
2022
IN_VITRO
2022
IN_VITRO
2022
IN_VITRO
2022
ANIMAL
2022
IN_VITRO
2021
ANIMAL
2021
IN_VITRO
2021
IN_VITRO
Browse all 259 papers →
Enhancing the Skatole Degradation Capacity of Lactococcus lactis NZ9000 Through the Heterologous Expression of the Ska Enzyme from Acinetobacter piscicola p38
· Fermentation
Construction of Lactococcus lactis Expression System via Chromosomal Integration of T7 RNA Polymerase for Levan Production from Fruit Pomace
· Journal of Agricultural and Food Chemistry
Rational Engineeringof Arginine Deiminase To Enhancethe Acid Tolerance of Lactic Acid Bacteria
· Figshare
Rational Engineering of Arginine Deiminase To Enhance the Acid Tolerance of Lactic Acid Bacteria
· Journal of Agricultural and Food Chemistry
Comparison of Postbiotics and Probiotics of Lactococcus lactis NZ9000 in Alleviating Liver Injury Induced by Bisphenol A via Binding and Removing Bisphenol A in Mouse Model
· Molecular Nutrition & Food Research
A Dual CRISPR-Cas/Cre- loxP Genome Engineering Strategy for Stable Uricase Expression in Food-Grade Probiotics
· ACS Synthetic Biology
Heterologous expression of P9 from Akkermansia muciniphila increases the GLP-1 secretion of intestinal L cells
· World Journal of Microbiology and Biotechnology
Heterologous expression of P9 from Akkermansia muciniphila improves the GLP-1 secretion of intestinal L cells.
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Effect of Secretion Efficiency of Mutant KRAS Neoantigen by Lactococcus lactis on the Immune Response of a Mucosal Vaccine Delivery Vehicle Targeting Colorectal Cancer
· International Journal of Molecular Sciences
Expression of β-Glucosidases from the Yak Rumen in Lactic Acid Bacteria: A Genetic Engineering Approach
· Microorganisms
Effect of treatment with Lactococcus lactis NZ9000 on intestinal microbiota and mucosal immune responses against Clostridium perfringens in broiler chickens
· Frontiers in Microbiology
Holin‐assisted bacterial recombinant protein export
· Biotechnology and Bioengineering
Comparative transcriptome analysis reveals the contribution of membrane transporters to acid tolerance in Lactococcus lactis
· Journal of Biotechnology
Development of Base Editors for Simultaneously Editing Multiple Loci in Lactococcus lactis
· ACS Synthetic Biology
Engineered Probiotic Lactococcus lactis for Lycopene Production against ROS Stress in Intestinal Epithelial Cells
· ACS Synthetic Biology
Mucosal immune responses induced by oral administration of recombinant Lactococcus lactis expressing the S1 protein of PDCoV
· Virology
Enhancing the biosynthesis of nicotinamide mononucleotide in Lactococcus lactis by heterologous expression of FtnadE*
· Journal of the Science of Food and Agriculture
Oral Immunization of Recombinant Lactococcus lactis and Enterococcus faecalis Expressing Dendritic Cell Targeting Peptide and Hexon Protein of Fowl Adenovirus 4 Induces Protective Immunity Against Homologous Infection
· Frontiers in Veterinary Science
Single-plasmid systems based on CRISPR-Cas9 for gene editing in Lactococcus lactis
· Journal of Dairy Science
Adherence and internalisation of Lactococcus lactis M4 towards human colorectal cancer cell line, Caco-2
· Malaysian Journal of Microbiology
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Citations
Selected papers that name this strain.
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[1]
PMID 41437716 →Comparison of Postbiotics and Probiotics of Lactococcus lactis NZ9000 in Alleviating Liver Injury Induced by Bisphenol A via Binding and Removing Bisphenol A in Mouse Model· Molecular Nutrition & Food Research · 2025
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[2]
PMID 31434565 →Surface display of hirame novirhabdovirus (HIRRV) G protein in Lactococcus lactis and its immune protection in flounder (Paralichthys olivaceus)· Microbial Cell Factories · 2019
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[3]
Source →Hypoglycemic effect of Lactococcus lactis vaccine containing HSP65-6P277 on streptozotocin-induced type 1 diabetic mice· Zhongguo yaoke daxue xuebao · 2014
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[4]
PMID 16437622 →Effect of oral Lactococcus lactis containing endostatin on 1, 2-dimethylhydrazine-induced colon tumor in rats· World Journal of Gastroenterology · 2005