Strain Profile
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Streptococcus thermophilus TH-4
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Human-origin
Where this strain was first isolated, curated from the literature and culture-collection catalogs. It describes provenance only — not suitability, and not benefit.
How we classify this →
Sequenced
Whether a public genome assembly is linked for this strain. Without one the genome screens cannot run. It is not a verdict on the organism.
How we classify this →
Public genome assembly available
Streptococcus thermophilus TH-4 is a dairy fermentation strain with a published record spanning animal models and human clinical trials. Animal studies have examined this strain in the context of intestinal mucositis — inflammation of the gut lining induced by chemotherapy agents including methotrexate, doxorubicin, and 5-fluorouracil. Human RCT evidence for TH-4 appears primarily in multi-strain pediatric formulations, with studies examining gut microbiota in preterm infants, cow's milk protein allergy, and antibiotic-associated microbiome changes. In vitro work has explored folate production and encapsulation methods. The animal mucositis research has not been confirmed in human trials. These are research topics, not findings; the papers do not establish that this strain treats or prevents any condition.
Where it's been studied Tags come from a conservative keyword scan of each paper's title, abstract, and summary. A tag is research coverage, not measured effect. How we classify this →
Share of this strain's 18 body-system-tagged papers that concern each system. Research coverage, not measured effect.
Symptoms in the research A tag means the paper's text names the symptom or condition — research coverage, not evidence of benefit. How we classify this →
Share of this strain's 7 symptom-tagged papers that mention each symptom or condition. Research coverage, not evidence of benefit.
+1 more symptoms
Research Study-type filters use AI-classified labels, audited but not guaranteed — check the paper itself before leaning on one. How we classify this →
30 papers reference this strain in the probiotic database.
Match confidence
How strongly this paper was matched to this strain when the corpus was linked. It orders the list — it says nothing about the study's quality or its findings.
How we classify this →
2024
ANIMAL
2024
OBSERVATIONAL
2024
IN_VITRO
2021
REVIEW
2021
RCT
2020
ANIMAL
2020
REVIEW
2019
IN_VITRO
2017
IN_VITRO
2014
RCT
2013
RCT
2013
ANIMAL
2013
RCT
2013
RCT
2013
RCT
2011
ANIMAL
2009
ANIMAL
2006
ANIMAL
2026
OBSERVATIONAL
2025
REVIEW
Browse all 30 papers →
Food by-products as substrates for the design of a folate bio-enriched fermented beverage: evaluation of bioavailability and effects on vitamin D receptor (VDR) and folate transporters gene expression in vitro and in vivo
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The Impact of Administering Prophylactic Probiotics to Premature Infants in Neonatal Intensive Care Units on Healthcare-Associated Infections, Necrotizing Enterocolitis, and Mortality
· Flora the Journal of Infectious Diseases and Clinical Microbiology
Effect of fruit by-products and orange pectin on folate (vitamin B9) production by selected starter and probiotic strains
· International Journal of Food Science & Technology
DO PROBIOTICS HAVE A FUTURE IN NEONATOLOGY?
· Neonatology surgery and perinatal medicine
The effect of probiotic supplementation on the gut microbiota of preterm infants
· Journal of Medical Microbiology
Potencial probiótico de leite fermentado com >i<Lactobacillus paracasei>/i< subsp. >i<paracasei>/i< F19 e >i<Streptococcus thermophilus>/i< TH-4: impacto da suplementação com bagaço de malte e influência sobre o receptor de vitamina D >i<in vivo>/i<
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Childhood functional gastrointestinal disorders: rational therapy
· Meditsinskiy sovet = Medical Council
Electrospun probiotics: an alternative for encapsulation.
· PubMed
The efficacy of bacterial and yeasts strains and their combination to bind aflatoxin B1 and B2 in artificially contaminated infants food
· Journal of Food Safety
Evaluation of the effects of a probiotic supplementation with respect to placebo on intestinal microflora and secretory IgA production, during antibiotic therapy, in children affected by recurrent airway infections and skin symptoms.
· PubMed
Efficacy of Probiotic Therapy in Young Children with Food Allergies
Эффективность использования пробиотической терапии у детей раннего возраста с пищевой аллергией
· Здоровье ребенка
Effects of Streptococcus thermophilus TH-4 in a rat model of doxorubicin-induced mucositis
· Scandinavian Journal of Gastroenterology
[Effect of probiotics on the dynamics of gastrointestinal symptoms of food allergy to cow's milk protein in infants].
· PubMed
[Clinical effectiveness of probiotics in complex treatment of infants with cow's milk allergy].
· PubMed
Effectiveness of Probiotic Therapy in Young Children with Food Allergies
Ефективність застосування пробіотичної терапії у дітей раннього віку з харчовою алергією
· CHILD`S HEALTH
Oral ingestion of Streptococcus thermophilus does not affect mucositis severity or tumor progression in the tumor-bearing rat
· Cancer Biology & Therapy
Effects of Streptococcus thermophilus TH-4 on intestinal mucositis induced by the chemotherapeutic agent, 5-Fluorouracil (5-FU)
· Cancer Biology & Therapy
Oral ingestion of streptococcus thermophilus diminishes severity of small intestinal mucositis in methotrexate treated rats
· Cancer Biology & Therapy
Probiotic Implementation and Necrotizing Enterocolitis Risk in Preterm Infants
· JAMA Network Open
An update on probiotics in paediatrics
· Current Opinion in Clinical Nutrition & Metabolic Care
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Citations
Selected papers that name this strain.
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[1]
Source →Probiotic Implementation and Necrotizing Enterocolitis Risk in Preterm Infants· JAMA Network Open · 2026
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[2]
Source →The Impact of Administering Prophylactic Probiotics to Premature Infants in Neonatal Intensive Care Units on Healthcare-Associated Infections, Necrotizing Enterocolitis, and Mortality· Flora the Journal of Infectious Diseases and Clinical Microbiology · 2024
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[3]
PMID 34431764 →The effect of probiotic supplementation on the gut microbiota of preterm infants· Journal of Medical Microbiology · 2021
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[4]
Source →DO PROBIOTICS HAVE A FUTURE IN NEONATOLOGY?· Neonatology surgery and perinatal medicine · 2021
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[5]
Source →Childhood functional gastrointestinal disorders: rational therapy· Meditsinskiy sovet = Medical Council · 2020
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[6]
PMID 24750797 →Evaluation of the effects of a probiotic supplementation with respect to placebo on intestinal microflora and secretory IgA production, during antibiotic therapy, in children affected by recurrent airway infections and skin symptoms.· PubMed · 2014
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[7]
PMID 23567307 →[Clinical effectiveness of probiotics in complex treatment of infants with cow's milk allergy].· PubMed · 2013
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[8]
Source →Efficacy of Probiotic Therapy in Young Children with Food AllergiesЭффективность использования пробиотической терапии у детей раннего возраста с пищевой аллергией· Здоровье ребенка · 2013
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[9]
PMID 23863210 →[Effect of probiotics on the dynamics of gastrointestinal symptoms of food allergy to cow's milk protein in infants].· PubMed · 2013