Strain Profile
· NCBI Strain Taxon
484020
NCBI Taxonomy's node for this specific strain. A different identifier from the culture-collection deposit numbers below, which name a physical stock rather than a taxonomic node.
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Bifidobacterium bifidum BGN4
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Human-origin
Where this strain was first isolated, curated from the literature and culture-collection catalogs. It describes provenance only — not suitability, and not benefit.
How we classify this →
Sequenced
Whether a public genome assembly is linked for this strain. Without one the genome screens cannot run. It is not a verdict on the organism.
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Public genome assembly available
Bifidobacterium bifidum BGN4 is a probiotic strain with a sequenced genome that has been studied primarily through in vitro and animal model research. Laboratory work has investigated antioxidant properties, including engineered variants expressing antioxidant enzymes, and animal studies have examined compounds produced by this strain in relation to gut microbial balance and inflammatory markers in intestinal tissue. One early animal study also examined a polysaccharide fraction in cancer-cell assays, exploratory work not applicable to human health claims. Strain-specific human clinical evidence is not currently available. These are research topics, not findings; the papers do not establish that this strain treats or prevents any condition.
Where it's been studied Tags come from a conservative keyword scan of each paper's title, abstract, and summary. A tag is research coverage, not measured effect. How we classify this →
Share of this strain's 40 body-system-tagged papers that concern each system. Research coverage, not measured effect.
+3 more systems
Symptoms in the research A tag means the paper's text names the symptom or condition — research coverage, not evidence of benefit. How we classify this →
Share of this strain's 16 symptom-tagged papers that mention each symptom or condition. Research coverage, not evidence of benefit.
Research Study-type filters use AI-classified labels, audited but not guaranteed — check the paper itself before leaning on one. How we classify this →
61 papers reference this strain in the probiotic database.
Match confidence
How strongly this paper was matched to this strain when the corpus was linked. It orders the list — it says nothing about the study's quality or its findings.
How we classify this →
2026
ANIMAL
2026
RCT
2025
IN_VITRO
2025
OBSERVATIONAL
2023
IN_VITRO
2022
IN_VITRO
2022
ANIMAL
2021
IN_VITRO
2021
ANIMAL
2021
ANIMAL
2021
OTHER
2021
ANIMAL
2019
IN_VITRO
2018
ANIMAL
2018
IN_VITRO
2018
IN_VITRO
2017
IN_VITRO
2017
ANIMAL
2016
REVIEW
2015
IN_VITRO
Browse all 61 papers →
Immunomodulatory Effects of Bifidobacterium bifidum BGN4 in Cyclophosphamide-induced Immunosuppressed Mice via Activation of NK Cells and Macrophages
· Probiotics and Antimicrobial Proteins
Probiotic Bifidobacterium bifidum BGN4 supplementation modulates gut microbiome composition and reduces circulating zonulin, TNFα, and insulin in adults with excess adiposity: a randomized, double-blind, placebo-controlled trial
· Nutrition & Metabolism
Enhancing Stability and Viability of Bifidobacterium Through Vitamin-Based Optimized Coating
비타민 기반 최적화 코팅을 통한 비피도박테리움의 안정성 및 생존력 향상
· Food Engineering Progress
Ab Initio Whole Cell Kinetic Model of Bifidobacterium bifidum BGN4 (bbfMA24)
· Acta Scientifci Nutritional Health
Bifidobacterium bifidum BGN4 fractions ameliorate palmitic acid-induced hepatocyte ferroptosis by inhibiting SREBP1-CYP2E1 pathway
· Journal of Investigative Medicine
A recombinant Bifidobacterium bifidum BGN4 strain expressing the streptococcal superoxide dismutase gene ameliorates inflammatory bowel disease
· Microbial Cell Factories
Bifidobacterium bifidum BGN4 Paraprobiotic Supplementation Alleviates Experimental Colitis by Maintaining Gut Barrier and Suppressing Nuclear Factor Kappa B Activation Signaling Molecules
· Journal of Medicinal Food
Production of biologically active human interleukin-10 by Bifidobacterium bifidum BGN4
· Microbial Cell Factories
Probiotics partially attenuate the severity of acute kidney injury through an immunomodulatory effect
· Kidney Research and Clinical Practice
Administration of Bifidobacterium bifidum BGN4 and Bifidobacterium longum BORI Improves Cognitive and Memory Function in the Mouse Model of Alzheimer’s Disease
· Frontiers in Aging Neuroscience
Lysed and disrupted Bifidobacterium bifidum BGN4 cells promote anti-inflammatory activities in lipopolysaccharide-stimulated RAW 264.7 cells
· Saudi Journal of Biological Sciences
Antioxidant and Anti-Inflammatory Properties of Recombinant Bifidobacterium bifidum BGN4 Expressing Antioxidant Enzymes
· Microorganisms
Construction of Recombinant Bifidobacterium bifidum BGN4 Expressing Bifidobacterial β-Galactosidase Gene and Application for Improvement of Lactose Intolerance
· Seoul National University Open Repository (Seoul National University)
Production of Selenomethionine-Enriched Bifidobacterium bifidum BGN4 via Sodium Selenite Biocatalysis
· Molecules
Improvement of electroporation-mediated transformation efficiency for a Bifidobacterium strain to a reproducibly high level
· Journal of Microbiological Methods
Safety Evaluations of Bifidobacterium bifidum BGN4 and Bifidobacterium longum BORI
· International Journal of Molecular Sciences
Development of Strain-Specific Primers for Identification of Bifidobacterium bifidum BGN4
· Journal of Microbiology and Biotechnology
Strain Specific Detection and Quantification of Probiotic Bifidobacterium bifidum BGN4 in Mouse Model and Positive Effect of B. bifidum BGN4 on Intestinal Microflora
· Seoul National University Open Repository (Seoul National University)
Review on Bifidobacterium bifidum BGN4: Functionality and Nutraceutical Applications as a Probiotic Microorganism
· International Journal of Molecular Sciences
High Expression of ��-Glucosidase in Bifidobacterium bifidum BGN4 and Application in Conversion of Isoflavone Glucosides During Fermentation of Soy Milk
· Journal of Microbiology and Biotechnology
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Citations
Selected papers that name this strain.
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[1]
PMID 42116047 →Probiotic Bifidobacterium bifidum BGN4 supplementation modulates gut microbiome composition and reduces circulating zonulin, TNFα, and insulin in adults with excess adiposity: a randomized, double-blind, placebo-controlled trial· Nutrition & Metabolism · 2026
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[2]
PMID 32300799 →Probiotic Supplementation Improves Cognitive Function and Mood with Changes in Gut Microbiota in Community-Dwelling Older Adults: A Randomized, Double-Blind, Placebo-Controlled, Multicenter Trial· The Journals of Gerontology Series A · 2020
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[3]
Source →Review on Bifidobacterium bifidum BGN4: Functionality and Nutraceutical Applications as a Probiotic Microorganism· International Journal of Molecular Sciences · 2016