Strain Profile
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Bifidobacterium breve M-16V
DEP
M-16V
◔
Human-origin
Where this strain was first isolated, curated from the literature and culture-collection catalogs. It describes provenance only — not suitability, and not benefit.
How we classify this →
Sequenced
Whether a public genome assembly is linked for this strain. Without one the genome screens cannot run. It is not a verdict on the organism.
How we classify this →
Public genome assembly available
Bifidobacterium breve M-16V is a well-studied strain with a particular focus on infant and neonatal applications. Multiple randomized controlled trials have examined its use in preterm and low-birth-weight infants, looking at gut microbiota colonization and short-chain fatty acid production in that population. Animal and human RCT research has also examined immune response modulation associated with allergic conditions, and a 2023 double-blind RCT in adults examined autonomic nervous system parameters in connection with changes in the gut environment. A 2022 animal study also examined this strain in the context of nanopolystyrene exposure and immune modulation under microplastic conditions. These are research topics, not findings; the papers do not establish that this strain treats or prevents any condition.
Where it's been studied Tags come from a conservative keyword scan of each paper's title, abstract, and summary. A tag is research coverage, not measured effect. How we classify this →
Share of this strain's 96 body-system-tagged papers that concern each system. Research coverage, not measured effect.
+3 more systems
Symptoms in the research A tag means the paper's text names the symptom or condition — research coverage, not evidence of benefit. How we classify this →
Share of this strain's 55 symptom-tagged papers that mention each symptom or condition. Research coverage, not evidence of benefit.
Research Study-type filters use AI-classified labels, audited but not guaranteed — check the paper itself before leaning on one. How we classify this →
112 papers reference this strain in the probiotic database.
Match confidence
How strongly this paper was matched to this strain when the corpus was linked. It orders the list — it says nothing about the study's quality or its findings.
How we classify this →
2026
RCT
2026
RCT
2025
ANIMAL
2025
RCT
2025
ANIMAL
2025
RCT
2025
RCT
2025
RCT
2025
IN_VITRO
2025
RCT
2025
RCT
2025
RCT
2025
RCT
2025
RCT
2025
REVIEW
2024
ANIMAL
2024
RCT
2024
ANIMAL
2024
ANIMAL
2023
RCT
Browse all 112 papers →
Nourishing the preterm brain
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School-Age Neurodevelopmental and Atopy Outcomes in Extremely Preterm Infants: Follow-Up from the Single Versus Triple-Strain Bifidobacterium Randomized Controlled Trial
· Nutrients
Bifidobacterium breve M-16V alleviates cow's milk allergy by regulating the gut microbiota and metabolites in human microbiota-associated mice
· Food & Function
Restoration of gut microbiota with a specific synbiotic-containing infant formula in healthy Chinese infants born by cesarean section
· European Journal of Clinical Nutrition
Bifidobacterium breve M‐16V Alleviates Cow's Milk Allergy in a Mouse Model via Gut Microbiota‐Derived Indole‐3‐Propionic Acid‐Aryl Hydrocarbon Receptor Signaling Axis
· Allergy
Image 5_Effects of a specific synbiotic blend on fecal short-chain fatty acids and gut inflammation in cow's milk-allergic children receiving amino acid–based formula during early life: results of a randomized controlled trial (PRESTO study).tif
· Figshare
Image 4_Effects of a specific synbiotic blend on fecal short-chain fatty acids and gut inflammation in cow's milk-allergic children receiving amino acid–based formula during early life: results of a randomized controlled trial (PRESTO study).tif
· Figshare
Imaging and Microorganism Analyses of the Effects of Oral Bifidobacterium breve Intake on Facial Skin in Females: A Randomized, Double-Blind, Placebo-Controlled Study
· Nutrients
Comprehensive analysis of cell-associated fatty acids in Bifidobacterium strains
· Bioscience Biotechnology and Biochemistry
Image 2_Effects of a specific synbiotic blend on fecal short-chain fatty acids and gut inflammation in cow's milk-allergic children receiving amino acid–based formula during early life: results of a randomized controlled trial (PRESTO study).jpeg
· Figshare
Image 1_Effects of a specific synbiotic blend on fecal short-chain fatty acids and gut inflammation in cow's milk-allergic children receiving amino acid–based formula during early life: results of a randomized controlled trial (PRESTO study).tif
· Figshare
Data Sheet 1_Effects of a specific synbiotic blend on fecal short-chain fatty acids and gut inflammation in cow's milk-allergic children receiving amino acid–based formula during early life: results of a randomized controlled trial (PRESTO study).pdf
· Figshare
Image 6_Effects of a specific synbiotic blend on fecal short-chain fatty acids and gut inflammation in cow's milk-allergic children receiving amino acid–based formula during early life: results of a randomized controlled trial (PRESTO study).tif
· Figshare
Image 3_Effects of a specific synbiotic blend on fecal short-chain fatty acids and gut inflammation in cow's milk-allergic children receiving amino acid–based formula during early life: results of a randomized controlled trial (PRESTO study).tif
· Figshare
Immunomodulatory Effects of Bifidobacterium Breve: Mechanism and Therapeutic Potential
· Trends in Pharmaceutical Biotechnology
Impact of maternal Bifidobacterium breve M-16V and scGOS/lcFOS supplementation during pregnancy and lactation on the maternal immune system and milk composition
· Frontiers in Immunology
A young child formula supplemented with a synbiotic mixture of scGOS/lcFOS and Bifidobacterium breve M-16V improves the gut microbiota and iron status in healthy toddlers
· Frontiers in Pediatrics
Maternal Synbiotic Supplementation with B. breve M-16V and scGOS/lcFOS Shape Offspring Immune Development and Gut Microbiota at the End of Suckling
· Nutrients
Early-Life Supplementation Enhances Gastrointestinal Immunity and Microbiota in Young Rats
· Foods
Bifidobacterium breve M-16V regulates the autonomic nervous system via the intestinal environment: A double-blind, placebo-controlled study
· Behavioural Brain Research
Discussion
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Citations
Selected papers that name this strain.
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[1]
PMID 41515257 →School-Age Neurodevelopmental and Atopy Outcomes in Extremely Preterm Infants: Follow-Up from the Single Versus Triple-Strain Bifidobacterium Randomized Controlled Trial· Nutrients · 2026
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[2]
Source →Image 1_Effects of a specific synbiotic blend on fecal short-chain fatty acids and gut inflammation in cow's milk-allergic children receiving amino acid–based formula during early life: results of a randomized controlled trial (PRESTO study).tif· Figshare · 2025
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[3]
Source →Immunomodulatory Effects of Bifidobacterium Breve: Mechanism and Therapeutic Potential· Trends in Pharmaceutical Biotechnology · 2025
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[4]
PMID 38128887 →Bifidobacterium breve M-16V regulates the autonomic nervous system via the intestinal environment: A double-blind, placebo-controlled study· Behavioural Brain Research · 2023
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[5]
PMID 35325770 →Multi-omics reveals that Bifidobacterium breve M-16V may alleviate the immune dysregulation caused by nanopolystyrene· Environment International · 2022
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[6]
PMID 33574421 →Impact of synbiotics on gut microbiota during early life: a randomized, double-blind study· Scientific Reports · 2021
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[7]
Source →Faculty Opinions recommendation of Bifidobacterium breve M-16V as a Probiotic for Preterm Infants: A Strain-Specific Systematic Review.· Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · 2019
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[8]
PMID 31164972 →A specific synbiotic-containing amino acid-based formula restores gut microbiota in non-IgE mediated cow’s milk allergic infants: a randomized controlled trial· Clinical and Translational Allergy · 2019
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[9]
PMID 30651972 →A specific synbiotic-containing amino acid-based formula in dietary management of cow’s milk allergy: a randomized controlled trial· Clinical and Translational Allergy · 2019
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[10]
PMID 29633642 →A synbiotic mixture of scGOS/lcFOS and Bifidobacterium breve M-16V increases faecal Bifidobacterium in healthy young children· Beneficial Microbes · 2018