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Lacticaseibacillus casei CRL431

◐ Food-origin
Sequenced
Public genome assembly available

Lacticaseibacillus casei CRL431 has a varied research portfolio spanning human RCTs, animal models, and in vitro studies. Long-term RCT evidence from a childhood supplementation program has examined associations between probiotic and calcium co-supplementation and hemoglobin levels and neurodevelopmental outcomes in adolescents, though calcium's role makes strain-specific attribution difficult. Animal model research has examined immune function, Salmonella infection models, and gut microbiota composition. In vitro and animal studies of cancer cell lines and chemotherapy models are exploratory and cannot be interpreted as treatment or prevention claims; those studies reflect early mechanistic research only. These are research topics, not findings; the papers do not establish that this strain treats or prevents any condition.

Where it's been studied

Share of this strain's 11 body-system-tagged papers that concern each system. Research coverage, not measured effect.

Gut 7 papers · 64%
Immune 7 papers · 64%
Respiratory 2 papers · 18%
Brain & Mood 1 paper · 9%
Metabolic 1 paper · 9%
Skin 1 paper · 9%

Symptoms in the research

Share of this strain's 4 symptom-tagged papers that mention each symptom or condition. Research coverage, not evidence of benefit.

Depression 1 paper · 25%
Diarrhea 1 paper · 25%
Respiratory infections 1 paper · 25%
Weight & obesity 1 paper · 25%

Research

13 papers reference this strain in the probiotic database.

Match confidence
2024 RCT
The Effect of Probiotics and Calcium Supplementation During Childhood on Hemoglobin Level and Anemia Prevalence: A 10-Year Follow-Up Study
· Current Developments in Nutrition
 2022 RCT
Long-term benefits of probiotics and calcium supplementation during childhood, and other biomedical and socioenvironmental factors, on adolescent neurodevelopmental outcomes
· Journal of Functional Foods
 2021 ANIMAL
Protective Effect of Lacticaseibacillus casei CRL 431 Postbiotics on Mitochondrial Function and Oxidative Status in Rats with Aflatoxin B1–Induced Oxidative Stress
· Probiotics and Antimicrobial Proteins
 2014 ANIMAL
Protective effect of lactobacillus casei CRL 431 against salmonella in a mouse model: mechanisms involved
· Conicet
 2013 IN_VITRO
Delivery of probiotic bacteria in long life ambient stable foods using a powdered food ingredient
· British Food Journal
 2012 ANIMAL
Stimulation of macrophages by immunobiotic Lactobacillus strains: influence beyond the intestinal tract
· Microbiology and Immunology
 2023 IN_VITRO
Effect of Lactobacillus (L. acidophilus NCIB1899, L. casei CRL 431, L. paracasei LP33) fermentation on free and bound polyphenolic, antioxidant activities in three Chenopodium quinoa cultivars
· Journal of Food Science
 2023 IN_VITRO
Cytotoxic Potentials of Cell-Free Supernatant Derived from Lactobacillus casei CRL431 on HCT-116 and HT-29 Human Colon Cancer Cell Lines
· Biointerface Research in Applied Chemistry
 2021 ANIMAL
Lactic Acid Bacteria Strains Differently Modulate Gut Microbiota and Metabolic and Immunological Parameters in High-Fat Diet-Fed Mice
· Frontiers in Nutrition
 2020 ANIMAL
Milk fermented by Lactobacillus casei CRL431 administered as an immune adjuvant in models of breast cancer and metastasis under chemotherapy
· Applied Microbiology and Biotechnology
 2020 ANIMAL
Lactobacillus casei CRL431 modulates hemostatic activation induced by protein malnourishment and pneumococcal respiratory infection
· Applied Microbiology and Biotechnology
 2018 ANIMAL
Modulation of intestinal microbiota and immunometabolic parameters by caloric restriction and lactic acid bacteria
· Food Research International
 2014 ANIMAL
Probiotic Lactobacillus strains protect against myelosuppression and immunosuppression in cyclophosphamide-treated mice
· International Immunopharmacology
Browse all 13 papers →

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Citations

Selected papers that name this strain.

  1. [1]
    The Effect of Probiotics and Calcium Supplementation During Childhood on Hemoglobin Level and Anemia Prevalence: A 10-Year Follow-Up Study
    · Current Developments in Nutrition · 2024
    Source →
  2. [2]
    Long-term benefits of probiotics and calcium supplementation during childhood, and other biomedical and socioenvironmental factors, on adolescent neurodevelopmental outcomes
    · Journal of Functional Foods · 2022
    Source →