Strain Profile
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Lactobacillus casei Shirota
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Food-origin
Where this strain was first isolated, curated from the literature and culture-collection catalogs. It describes provenance only — not suitability, and not benefit.
How we classify this →
Sequenced
Whether a public genome assembly is linked for this strain. Without one the genome screens cannot run. It is not a verdict on the organism.
How we classify this →
Public genome assembly available
Lactobacillus casei Shirota is one of the most extensively studied probiotic strains, with a research history spanning several decades. In vitro studies have examined its competition with gastrointestinal pathogens for intestinal adhesion sites, and separate cell-based experiments have explored its interaction with human immune responses. A small number of randomized controlled trials have examined this strain in combination formulations, including one human trial assessing glycemic and appetite responses to a multi-ingredient drink, though these multi-component designs make it difficult to attribute effects to L. casei Shirota alone. The evidence base is broad but heterogeneous. These are research topics, not findings; the papers do not establish that this strain treats or prevents any condition.
Where it's been studied Tags come from a conservative keyword scan of each paper's title, abstract, and summary. A tag is research coverage, not measured effect. How we classify this →
Share of this strain's 414 body-system-tagged papers that concern each system. Research coverage, not measured effect.
Symptoms in the research A tag means the paper's text names the symptom or condition — research coverage, not evidence of benefit. How we classify this →
Share of this strain's 191 symptom-tagged papers that mention each symptom or condition. Research coverage, not evidence of benefit.
+16 more symptoms
Research Study-type filters use AI-classified labels, audited but not guaranteed — check the paper itself before leaning on one. How we classify this →
644 papers reference this strain in the probiotic database.
Match confidence
How strongly this paper was matched to this strain when the corpus was linked. It orders the list — it says nothing about the study's quality or its findings.
How we classify this →
2026
OBSERVATIONAL
2026
OBSERVATIONAL
2026
OBSERVATIONAL
2026
OTHER
2026
RCT
2026
REVIEW
2026
REVIEW
2026
REVIEW
2026
IN_VITRO
2026
RCT
2025
IN_VITRO
2025
RCT
2025
IN_VITRO
2025
OBSERVATIONAL
2025
IN_VITRO
2025
REVIEW
2025
OBSERVATIONAL
2025
REVIEW
2025
ANIMAL
2025
ANIMAL
Browse all 644 papers →
Effects of fermented milk containing Lacticaseibacillus paracasei strain Shirota on constipation and gut microbiota: A randomised pilot study in Vietnam
· Beneficial Microbes
Effect of Probiotics on Respiratory Infections in Stunted Preschool Children: A Quasi-Experimental Pre-Post Study
· Indonesian Journal of Human Nutrition
Association between habitual intake of fermented milk products containing lactic acid bacteria and all-cause mortality: a community-based cohort prospective study
· The journal of nutrition health & aging
A fermented milk drink containing Lactobacillus casei strain Shirota modulates the esophageal microbiome composition in Barrett’s esophagus
· iScience
A randomized controlled trial of probiotics to reduce the severity of oral mucositis in patients with oropharyngeal carcinoma undergoing concurrent chemoradiotherapy
· Journal of Cancer Research and Therapeutics
Neuromodulatory potential of probiotic: The role of Lactobacillus Casei Shirota in neurological disease rodent models
· International Journal of Pharmaceutical Research and Development
Probiotics: An Overview of the Historical Development, Types, Sources, Health Benefits and Possible Risks of Probiotics of African Origin
· IntechOpen eBooks
Editorial: Special Issue on Yakult International Symposia on Beneficial Microbes—Fundamental Science and Innovative Applications, Sao Paulo, SP, Brazil, 27–28 March 2025
· Molecular Nutrition & Food Research
Peningkatan Stabilitas Fisik dan Penerimaan Sensoris Es Krim Fermentasi Fungsional melalui Fortifikasi Mangga
· Jurnal Teknologi dan Mutu Pangan
Improvement effect of synbiotics intake on stool frequency in constipation-prone healthy participants: placebo-controlled, randomised, double-blind, parallel-group comparison
· Beneficial Microbes
Study on the metabolitic profile of Lacticaseibacillus paracasei Shirota 51C
· BIO Web of Conferences
Effect of Daily Consumption of a Fermented Milk Containing Lacticaseibacillus paracasei Strain Shirota (LcS) on Stool Consistency in United States Adults with Hard or Lumpy Stools: A Randomized Controlled Trial
· Journal of Nutrition
Lacticaseibacillus rhamnosus GG and Lactobacillus casei Shirota Growth on a Medium Enriched with Rye Protein, and Assessment of DPP-IV Inhibitory Activity
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Effect of long-term consumption of Lacticaseibacillus paracasei strain Shirota-fermented milk on weight loss in the institutionalized oldest old: an exploratory study
· Bioscience of Microbiota Food and Health
Identification and functional analysis of two oligopeptide transporters supporting the growth of Lacticaseibacillus paracasei strain Shirota in milk
· Microbiology
Lactobacillus casei Shirota and Inflammatory Biomarkers: A Literature Review
· Biomedical & Pharmacology Journal
Lactobacillus casei Shirota intervention modulates the esophageal microbiome composition in Barrett’s esophagus
· medRxiv
Comprehensive Review of Dietary Probiotics in Reducing Aflatoxin B1 Toxicity
· Toxins
Differences in the Effects of Topical and Systemic Lactobacillus casei Shirota Probiotics on Plasma Cell and Macrophage Numbers in Traumatic Ulcer Healing in Wistar Rats (Rattus norvegicus)
Differences in the Effects of Topical and Systemic Lаctobаcillus Cаsei Shirotа Probiotics on Plаsmа Cell аnd Mаcrophаge Numbers in Trаumаtic Ulcer Heаling in Wistаr Rаts (Rаttus Norvegicus)
· Research Journal of Pharmacy and Technology
Differential Expression of IL-6 Following Topical Administration of the Probiotic Lactobacillus Casei Shirota in the Healing of Traumatic Ulcers in Wistar Rats (Rattus Novergicus)
· Research Journal of Pharmacy and Technology
Discussion
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Citations
Selected papers that name this strain.
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[1]
PMID 41813563 →Editorial: Special Issue on Yakult International Symposia on Beneficial Microbes—Fundamental Science and Innovative Applications, Sao Paulo, SP, Brazil, 27–28 March 2025· Molecular Nutrition & Food Research · 2026
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[2]
PMID 42612506 →Association between habitual intake of fermented milk products containing lactic acid bacteria and all-cause mortality: a community-based cohort prospective study· The journal of nutrition health & aging · 2026
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[3]
PMID 41980711 →Effects of fermented milk containing Lacticaseibacillus paracasei strain Shirota on constipation and gut microbiota: A randomised pilot study in Vietnam· Beneficial Microbes · 2026
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[4]
PMID 42628950 →Improvement effect of synbiotics intake on stool frequency in constipation-prone healthy participants: placebo-controlled, randomised, double-blind, parallel-group comparison· Beneficial Microbes · 2026
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[5]
PMID 40024315 →Effect of Daily Consumption of a Fermented Milk Containing Lacticaseibacillus paracasei Strain Shirota (LcS) on Stool Consistency in United States Adults with Hard or Lumpy Stools: A Randomized Controlled Trial· Journal of Nutrition · 2025
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[6]
PMID 40636156 →Lacticaseibacillus paracasei strain Shirota suppresses upper respiratory tract infections and activates mononuclear phagocytic cells in healthy Japanese office workers: a randomized, double-blind, controlled trial· Bioscience of Microbiota Food and Health · 2025
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[7]
PMID 40182598 →Randomized study of Lacticaseibacillus fermented milk in Indonesian elderly houses: Impact on gut microbiota and gut environment· World Journal of Gastroenterology · 2025
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[8]
PMID 41150183 →Comprehensive Review of Dietary Probiotics in Reducing Aflatoxin B1 Toxicity· Toxins · 2025
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[9]
Source →Glyco-phenotyping of mutants of Lacticaseibacillus paracasei by lectin microarray· bioRxiv (Cold Spring Harbor Laboratory) · 2024
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[10]
PMID 39064686 →The Effect of Probiotics on the Management of Pain and Inflammation in Osteoarthritis: A Systematic Review and Meta-Analysis of Clinical Studies· Nutrients · 2024