Strain Profile
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Lacticaseibacillus rhamnosus GR-1
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Food-origin
Where this strain was first isolated, curated from the literature and culture-collection catalogs. It describes provenance only — not suitability, and not benefit.
How we classify this →
Sequenced
Whether a public genome assembly is linked for this strain. Without one the genome screens cannot run. It is not a verdict on the organism.
How we classify this →
Public genome assembly available
Lacticaseibacillus rhamnosus GR-1 is among the most thoroughly researched probiotic strains for urogenital health, with multiple randomized controlled trials evaluating its oral use in relation to vaginal microbiota composition. It has been studied as an adjunctive approach alongside standard antibiotic therapy for bacterial vaginosis. In vitro work has characterized specific surface proteins that mediate adherence to vaginal epithelium and interact with immune signaling in bladder cells, documented in laboratory settings. GR-1 is most commonly paired with L. reuteri RC-14 in clinical research; its effects when used alone are less extensively documented. These are research topics, not findings; the papers do not establish that this strain treats or prevents any condition.
Where it's been studied Tags come from a conservative keyword scan of each paper's title, abstract, and summary. A tag is research coverage, not measured effect. How we classify this →
Share of this strain's 69 body-system-tagged papers that concern each system. Research coverage, not measured effect.
+2 more systems
Symptoms in the research A tag means the paper's text names the symptom or condition — research coverage, not evidence of benefit. How we classify this →
Share of this strain's 42 symptom-tagged papers that mention each symptom or condition. Research coverage, not evidence of benefit.
Research Study-type filters use AI-classified labels, audited but not guaranteed — check the paper itself before leaning on one. How we classify this →
87 papers reference this strain in the probiotic database.
Match confidence
How strongly this paper was matched to this strain when the corpus was linked. It orders the list — it says nothing about the study's quality or its findings.
How we classify this →
2026
ANIMAL
2026
IN_VITRO
2025
ANIMAL
2025
RCT
2025
RCT
2025
IN_VITRO
2024
RCT
2024
IN_VITRO
2023
IN_VITRO
2022
IN_VITRO
2022
ANIMAL
2022
IN_VITRO
2021
IN_VITRO
2021
RCT
2020
ANIMAL
2020
RCT
2020
IN_VITRO
2019
IN_VITRO
2019
IN_VITRO
2018
WGS
Browse all 87 papers →
Lacticaseibacillus rhamnosus GR-1 attenuates Escherichia coli-induced endometritis in mice, accompanied by modulation of uterine microbiota and metabolite profiles
· bioRxiv (Cold Spring Harbor Laboratory)
Lacticaseibacillus rhamnosus GR-1 Alleviates Escherichia coli-induced Autophagy-dependent Ferroptosis in Bovine Endometrial Epithelial Cells via FOXO1 Signaling
· Probiotics and Antimicrobial Proteins
Lacticaseibacillus rhamnosus GR-1 prevents autism-like behaviors by reshaping the maternal and offspring microbiome
· npj Biofilms and Microbiomes
Changes in the Genital Microbiome and Inflammation Among Women Using 30-Day L. Rhamnosus/L. Reuteri Probiotic in Combination with Intravaginal Estradiol: Findings from a Pilot, Open-Label, Phase I Clinical Trial
· medRxiv
Probiotic ice cream influences gut and vaginal microbiota in women at high risk of preterm birth: a randomized controlled study
· Maternal Health Neonatology and Perinatology
Lactobacillus rhamnosus GR-1 alleviates Escherichia coli-triggered bovine endometrial epithelial cells damage via the reactive oxygen species-mitochondrial pathway
· Animal Bioscience
Bacterial Vaginosis: Aspects of Diagnosis and Experience of Comprehensive Treatment in Women of Reproductive Age
БАКТЕРІАЛЬНИЙ ВАГІНОЗ: АСПЕКТИ ДІАГНОСТИКИ І ДОСВІД КОМПЛЕКСНОГО ЛІКУВАННЯ У ЖІНОК РЕПРОДУКТИВНОГО ВІКУ
· Health & Education
Impact of fruit powders incorporation on probiotic viability and sensory properties of yogurt
· Nutrition & Food Science
Recombinant p40 Protein Promotes Expression of Occludin in HaCaT Keratinocytes: A Brief Communication
· Microorganisms
Development of probiotic yogurt from almond and cow’s milk using Lacticaseibacillus rhamnosus GR-1
· Nutrition & Food Science
Probiotic Lactobacillus rhamnosus GR-1 supplementation attenuates Pb-induced learning and memory deficits by reshaping the gut microbiota
· Frontiers in Nutrition
Lactobacillus rhamnosus GR-1 Alleviates Escherichia coli-Induced Inflammation via NF-κB and MAPKs Signaling in Bovine Endometrial Epithelial Cells
· Frontiers in Cellular and Infection Microbiology
Development of Probiotic Almond Beverage Using Lacticaseibacillus rhamnosus GR-1 Fortified with Short-Chain and Long-Chain Inulin Fibre
· Fermentation
Probiotic Lacticaseibacillus rhamnosus GR-1 and Limosilactobacillus reuteri RC-14 as an Adjunctive Treatment for Bacterial Vaginosis Do Not Increase the Cure Rate in a Chinese Cohort: A Prospective, Parallel‐Group, Randomized, Controlled Study
· Frontiers in Cellular and Infection Microbiology
Lactobacillus rhamnosus probiotic prevents airway function deterioration and promotes gut microbiome resilience in a murine asthma model
· Gut Microbes
A Randomized Controlled Open Label Crossover Trial to Study Vaginal Colonization of Orally Administered Lactobacillus Reuteri RC-14 and Rhamnosus GR-1 in Pregnant Women at High Risk for Preterm Labor
· Nutrients
Microbial and Sensory Analysis of Soy and Cow Milk-Based Yogurt as a Probiotic Matrix for Lactobacillus rhamnosus GR-1
· Fermentation
Protective Effect of Probiotic Bacteria and Estrogen in Preventing HIV-1-Mediated Impairment of Epithelial Barrier Integrity in Female Genital Tract
· Cells
Probiotic Lactobacillus rhamnosus GR-1 is a unique prophylactic agent that suppresses infection-induced myometrial cell responses
· Scientific Reports
Comparative Genomic and Phenotypic Analysis of the Vaginal Probiotic Lactobacillus rhamnosus GR-1
· Frontiers in Microbiology
Discussion
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Citations
Selected papers that name this strain.
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[1]
Source →PROBIOTICS IN THE PREVENTION AND TREATMENT OF UROGENITAL INFECTIONS IN POSTMENOPAUSAL WOMEN: A SYSTEMATIC REVIEW· International Journal of Innovative Technologies in Social Science · 2026
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[2]
PMID 41331700 →Probiotic ice cream influences gut and vaginal microbiota in women at high risk of preterm birth: a randomized controlled study· Maternal Health Neonatology and Perinatology · 2025
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[3]
PMID 35928850 →Probiotic Lactobacillus rhamnosus GR-1 supplementation attenuates Pb-induced learning and memory deficits by reshaping the gut microbiota· Frontiers in Nutrition · 2022
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[4]
PMID 30886179 →Probiotic Lactobacillus rhamnosus GR-1 is a unique prophylactic agent that suppresses infection-induced myometrial cell responses· Scientific Reports · 2019
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[5]
PMID 27590374 →Oral Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14 to reduce Group B Streptococcus colonization in pregnant women: A randomized controlled trial· Taiwanese Journal of Obstetrics and Gynecology · 2016
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[6]
PMID 27869151 →The lectin-like protein 1 in Lactobacillus rhamnosus GR-1 mediates tissue-specific adherence to vaginal epithelium and inhibits urogenital pathogens· Scientific Reports · 2016
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[7]
Source →Lactobacilli versus antibiotics to prevent urinary tract infections: A randomized, double-blind, noninferiority trial in postmenopausal women· Nederlandsch tijdschrift voor geneeskunde/Nederlands tijdschrift voor geneeskunde/NTvG-databank · 2013